Effect of Vitamin A Deficiency on the Pulmonary and Hepatic
Drug-Metabolizing Enzymes in Rat

Sc, Dogra; Khanduja, Krishan Lal; Mp, Gupta; Sharma, Reetika

doi:10.1159/000469557

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…Our earlier studies in this area (Dogra et al, 1982;Dogra et al, 1983) (Dogra et al, 1984). These studies give support to the argument that mixed-function oxidase enzymes play a very crucial and important role in determining organ susceptibility to tumourigenesis.…”

Section: Discussionmentioning

confidence: 87%

The effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung tumourigenesis in rats

Dogra¹,

Khanduja²,

Gupta³

1985

Br J Cancer

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Summary The present investigation shows the effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung carcinogenesis in male Wistar rats. Lung tumours were induced by giving three intratracheal instillations, one week apart, of 10mg benzo(a)pyrene per instillation. Maximum tumour incidence (100%) and tumour burden per rat was found in rats which were kept on vitamin A deficient diet for 4 weeks prior to the first administration and 8 weeks after the last administration of benzo(a)pyrene. Rats in which vitamin A deficiency was terminated after the last administration of the carcinogen had 83% tumour incidence, whereas corresponding control pairfed animals had 39% incidence of tumours. These data represent the values obtained 32 weeks after the last administered dose of the carcinogen and indicate the role of vitamin A, both in the initiation as well as in the postinitiation phases of lung carcinogenesis.

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Section: Discussionmentioning

confidence: 87%

The effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung tumourigenesis in rats

Dogra¹,

Khanduja²,

Gupta³

1985

Br J Cancer

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“…GPX proteins along with SOD and catalase are part of the enzymatic defense system that cells use to reduce free radical-mediated cellular injury. Vitamin A deficiency leads to lower GSH/GSSG ratio in rat liver ( Barber et al, 2000 ), less activity of glutathione-S-transferase in lung ( Dogra et al, 1982 ), and less lung SOD and catalase ( Dogra et al, 1983 ). An antioxidant mechanism of vitamin A may be attributed to transcriptional regulation of antioxidant genes.…”

Section: Discussionmentioning

confidence: 99%

Vitamin A Protects the Preterm Lamb Diaphragm Against Adverse Effects of Mechanical Ventilation

et al. 2018

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Background: Preterm infants are deficient in vitamin A, which is essential for growth and development of the diaphragm. Preterm infants often require mechanical ventilation (MV) for respiratory distress. In adults, MV is associated with the development of ventilationinduced diaphragm dysfunction and difficulty weaning from the ventilator. We assessed the impact of MV on the preterm diaphragm and the protective effect of vitamin A during MV.Methods: Preterm lambs delivered operatively at ∼131 days gestation (full gestation: 150 days) received respiratory support by synchronized intermittent mandatory ventilation for 3 days. Lambs in the treated group received daily (24 h) enteral doses of 2500 IU/kg/day vitamin A combined with 250 IU/kg/day retinoic acid (VARA) during MV, while MV control lambs received saline. Unventilated fetal reference lambs were euthanized at birth, without being allowed to breathe. The fetal diaphragm was collected to quantify mRNA levels of myosin heavy chain (MHC) isoforms, atrophy genes, antioxidant genes, and pro-inflammatory genes; to determine ubiquitin proteasome pathway activity; to measure the abundance of protein carbonyl, and to investigate metabolic signaling.Results: Postnatal MV significantly decreased expression level of the neonatal MHC gene but increased expression level of MHC IIx mRNA level (p < 0.05). Proteasome activity increased after 3 days MV, accompanied by increased MuRF1 mRNA level and accumulated protein carbonyl abundance. VARA supplementation decreased proteasome activity and FOXO1 signaling, down-regulated MuRF1 expression, and reduced reactive oxidant production.Conclusion: These findings suggest that 3 days of MV results in abnormal myofibrillar composition, activation of the proteolytic pathway, and oxidative injury of diaphragms in mechanically ventilated preterm lambs. Daily enteral VARA protects the preterm diaphragm from these adverse effects.

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“…Interestingly, although the roles of vitamins A, C, and E have already been investigated in the lung exposed to NO 2 (Dogra et al, 1983;Tom et al, 1985;Hatch et al, 1986;Sevanian et al, 1982), with the exception of one study on respiratory pentane (Dillard et al, 1980), the influence of selenium (Se) on the lung response to NO 2 exposure has, to the best of our knowledge, not yet been reported, although numerous selenium supplementation studies can be found in the literature. The antioxidant role of selenium is dependent on the action of three selenium-containing enzyme classes, cytosolic glutathione peroxidase, membrane-bound phospholipid hydroperoxide glutathione peroxidase, and thioredoxin reductase, which in turn control the redox tone and the levels of cellular hydroperoxides and may also be responsible for the effects of selenium on the immune system.…”

mentioning

confidence: 99%

Lung Permeability, Antioxidant Status, and NO₂Inhalation: A Selenium Supplementation Study in Rats∗

Burbure

Heilier

Nève

et al. 2007

Journal of Toxicology and Environmental Health, Part A

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Little is known about antioxidant status, selenium status in particular, and lung response to NO2, which acts as a proinflammatory air pollutant. The effects of a low selenium diet (1.3 microg Se/d) with or without selenium supplementation were therefore studied in 128 Wistar rats, 2 mo old, male exposed to either acute (50 ppm, 30 min), intermittent subacute (5 ppm, 6 h/d, 5 d), intermittent long-term NO2 (1 ppm, 10 ppm, 6 h/d, 5 d/wk, 28 d), or normal atmospheric air (controls). Following sacrifice, measurements of lipid peroxidation (thiobarbituric acid-reactive substances, chemiluminescence), antioxidative protective enzymes (glutathione peroxidase [GPx], superoxide dismutase [SOD], glutathione S-transferase [GST], ceruloplasmin), lung damage (lactate dehydrogenase, alkaline and acid phosphatases), lung permeability (total protein, albumin), and inflammation (cell populations), along with the determination of new biomarkers such as CC16 (Clara-cell protein), were performed in serum and bronchoalveolar lavage fluid (BALF). While selenium-supplemented animals had increased GPx activity in serum prior to inhalation experiments, they also had decreased BALF CC16, blood SOD, and GST levels. Nevertheless, the protective role of normal selenium status with respect to NO2 lung toxicity was evident both for long-term and acute exposures, as the increase in BALF total proteins and corresponding decrease in serum (indicating increased lung permeability) was significantly more pronounced in selenium-deficient animals. During the various inhalation experiments, serum CC16 demonstrated its key role as an early marker of increased lung permeability. These findings corroborate the important role of selenium status in NO2 oxidative damage modulation, but also indicate, in view of its negative impact on CC16, a natural anti-inflammatory and immunosuppressor, that caution should be used prior to advocating selenium supplementation.

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Effect of Vitamin A Deficiency on the Pulmonary and Hepatic Drug-Metabolizing Enzymes in Rat

Cited by 8 publications

References 15 publications

The effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung tumourigenesis in rats

The effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung tumourigenesis in rats

Vitamin A Protects the Preterm Lamb Diaphragm Against Adverse Effects of Mechanical Ventilation

Lung Permeability, Antioxidant Status, and NO₂Inhalation: A Selenium Supplementation Study in Rats∗

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Effect of Vitamin A Deficiency on the Pulmonary and Hepatic Drug-Metabolizing Enzymes in Rat

Cited by 8 publications

References 15 publications

The effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung tumourigenesis in rats

The effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung tumourigenesis in rats

Vitamin A Protects the Preterm Lamb Diaphragm Against Adverse Effects of Mechanical Ventilation

Lung Permeability, Antioxidant Status, and NO2Inhalation: A Selenium Supplementation Study in Rats∗

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Lung Permeability, Antioxidant Status, and NO₂Inhalation: A Selenium Supplementation Study in Rats∗