Effect of viscous macromolecules on peritoneal plasminogen activator activity: A potential mechanism for their ability to reduce postoperative adhesion formation

Mayer, Michael; Yedgar, Saul; Hurwitz, Arie; Palti, Z.; Finzi, Zvezdana; Milwidsky, Ariel

doi:10.1016/s0002-9378(88)80181-9

Cited by 29 publications

(3 citation statements)

References 14 publications

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“…It has been conjectured that these substances act through a mechanical flotation method separating opposing organ by a physical barrier [14] and a siliconizing effect. More recent speculation suggests that CMC coatings prevent removal of plasminogen from traumatized surfaces, thereby increasing its availability for activation [15].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of resorbable barrier for preventing surgical adhesions

Zhang

Tian

Cui

2005

Current Applied Physics

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Section: Discussionmentioning

confidence: 99%

“…First of all, it was biocompactable, degradable and resorbable with a longer residence time than pure CMC and other natural degradable polymers. Moreover it could bate the hyperplasia of fibroblast and the secretion of collagen [15,18]. And it was cheap and easy to use.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of resorbable barrier for preventing surgical adhesions

Zhang

Tian

Cui

2005

Current Applied Physics

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“…The most important and widely recognized mechanism for its anti‐adhesion is the biomechanical isolation. CMC can also weaken the activity or proliferation of fibroblasts, prevent fibrin deposition on the damaged serosal surface, prevent the removal of plasminogen from the wound surface, and increase its activation effectiveness. Adanali et al .…”

Section: Demineralized Bone Matrix Carriersmentioning

confidence: 99%

Demineralized Bone Matrix Carriers and their Clinical Applications: An Overview

Zhang

Yang

et al. 2019

Orthopaedic Surgery

106

102

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Reconstruction of massive bone defects is challenging for orthopaedic clinicians, especially in cases of severe trauma and resection of tumors in various locales. Autologous iliac crest bone graft (ICBG) is the “gold standard” for bone grafting. However, the limited availability and complications at donor sites resulted in seeking other options like allografts and bone graft substitutes. Demineralized bone matrix (DBM) is a form of allograft using acidic solution to remove mineral components, while leaving much of the proteinaceous components native to bone, with small amounts of calcium‐based solids, inorganic phosphates, and some trace cell debris. It is an osteoconductive and osteoinductive biomaterial and is approved as a medical device for use in bone defects and spinal fusion. To pack consistently into the defect sites and stay firmly in the filling parts, DBM products have various forms combined with biocompatible viscous carriers, including sponges, strips, injectable putty, paste, and paste infused with chips. The present review aims to summarize the properties of various kind of viscous carriers and their clinical use combined with DBM in commercially available products. Given DBM'mercially available products. Given DBM;s long clinical track record and commercial accessibility in standard forms, opportunities to further develop and validate DBM as a versatile bone biomaterial in orthopaedic repair and regenerative medicine contexts are attractive.

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Pathophysiology, Prevention, and Treatment of Adhesions

Mueller¹

2017

The Equine Acute Abdomen

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Effect of viscous macromolecules on peritoneal plasminogen activator activity: A potential mechanism for their ability to reduce postoperative adhesion formation

Cited by 29 publications

References 14 publications

Evaluation of resorbable barrier for preventing surgical adhesions

Evaluation of resorbable barrier for preventing surgical adhesions

Demineralized Bone Matrix Carriers and their Clinical Applications: An Overview

Pathophysiology, Prevention, and Treatment of Adhesions

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