Effect of viscosity on harmonics signals of magnetic nanoparticles for thermometry application

Elrefai, Ahmed L.; Yonetani, Takashi; Enpuku, Keiji

doi:10.1016/j.jmmm.2019.165480

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…By extension, the physics supports a potential to extract temperature from time-dependent response(s) of MIONP magnetization when acted on by an AMF. However, the complexities of these responses demand a robust physical model, complete understanding of the MIONP physical and magnetic properties in biological conditions, and accurate calibration (Elrefai et al, 2019;Perreard et al, 2014;Rauwerdink & Weaver, 2010;Weaver et al, 2009;Wu et al, 2017Wu et al, , 2019. Much of the effort to develop MNT has focused on AMF excitations <5 kHz (possible within MR scanner), whereas MFH is typically performed at 100-300 kHz and requires hysteresis precluding MR technology.…”

Section: Combining Mpi With Mfh: a Logical Next Evolutionary Stepmentioning

confidence: 99%

Clinical magnetic hyperthermia requires integrated magnetic particle imaging

Healy

Bakuzis

Goodwill³

et al. 2022

WIREs Nanomed Nanobiotechnol

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Magnetic nanomaterials that respond to clinical magnetic devices have significant potential as cancer nanotheranostics. The complexities of their physics, however, introduce challenges for these applications. Hyperthermia is a heat‐based cancer therapy that improves treatment outcomes and patient survival when controlled energy delivery is combined with accurate thermometry. To date, few technologies have achieved the needed evolution for the demands of the clinic. Magnetic fluid hyperthermia (MFH) offers this potential, but to be successful it requires particle‐imaging technology that provides real‐time thermometry. Presently, the only technology having the potential to meet these requirements is magnetic particle imaging (MPI), for which a proof‐of‐principle demonstration with MFH has been achieved. Successful clinical translation and adoption of integrated MPI/MFH technology will depend on successful resolution of the technological challenges discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

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Section: Combining Mpi With Mfh: a Logical Next Evolutionary Stepmentioning

confidence: 99%

Clinical magnetic hyperthermia requires integrated magnetic particle imaging

Healy

Bakuzis

Goodwill³

et al. 2022

WIREs Nanomed Nanobiotechnol

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“…In this work, they proposed a method to accurately estimate both the viscosity and temperature of a SPION sample even when the viscosity is unknown in advance, allowing for precise thermometry. 117…”

Section: Mps As An Auxiliary Toolmentioning

confidence: 99%

“…Elrefai et al investigated the effects of viscosity on the harmonic signals of SPIONs for thermometry applications. In this work, they proposed a method to accurately estimate both the viscosity and temperature of a SPION sample even when the viscosity is unknown in advance, allowing for precise thermometry …”

Section: Mps As An Auxiliary Toolmentioning

confidence: 99%

Magnetic Particle Spectroscopy: A Short Review of Applications Using Magnetic Nanoparticles

Saha

et al. 2020

ACS Appl. Nano Mater.

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Magnetic particle spectroscopy (MPS), also called magnetization response spectroscopy, is a novel measurement tool derived from magnetic particle imaging (MPI). It can be interpreted as a zero-dimensional version of MPI scanner. MPS was primarily designed for characterizing superparamagnetic iron oxide nanoparticles (SPIONs) regarding their applicability for MPI. In recent years, it has evolved into an independent, versatile, highly sensitive, inexpensive platform for biological and biomedical assays, cell labeling and tracking, and blood analysis. MPS has also developed into an auxiliary tool for magnetic imaging and hyperthermia by providing high spatial and temporal mappings of temperature and viscosity. Furthermore, other MPS-based applications are being explored such as magnetic fingerprints for product tracking and identification in supply chains. There are a variety of novel MPS-based applications being reported and demonstrated by many groups. In this short review, we highlighted some of the representative applications based on MPS platform, thereby providing a roadmap of this technology and our insights for researchers in this area.

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“…A number of more or less direct measurement techniques aimed to relate the local temperature of a host medium to the changes of some physical property have been proposed in recent years. Temperature-sensitive properties not involving the use of ionizing radiation include amplitude 20,24–26 or phase 16,27 of one of the higher-order harmonics of the magnetization signal, the ratio between harmonics of the same signal, 19,28,29 the relaxation time of nanoparticles, 30 the viscosity of the host medium, 31 the proton resonance frequency or relaxation time as in MRI thermometry, 32 various ultrasonic properties. 14 Some techniques are applied in non-biological environments as well, as for instance in vehicle batteries 33,34…”

Section: Introductionmentioning

confidence: 99%

“…Measuring the temperature via the reversible changes of the magnetic properties of the same nanoparticles used to heat a tissue (mainly through the harmonics of the picked-up signal as in MPI/MPS) is possibly the prevalent and most direct strategy, 16,19,20,24–29 and one which can be equally applied to particles floating in a fluid environment or firmly blocked in a tissue. However, operating frequencies typical of MPI/MPS do not match the ones needed to obtain a good heating performance, so that making use of just one frequency 26 to combine thermometry and hyperthermia may result in a non-optimal heating process.…”

Section: Introductionmentioning

confidence: 99%