Effect of Viscosity and Concentration of Wall Former, Emulsifier and Pore-Inducer on the Properties of Amoxicillin Microcapsules Prepared by Emulsion Solvent Evaporation

Song, Mingna; Li, Ning; Sun, Song Yung; Tiedt, L. R.; Liebenberg, Wilna; Villiers, Melgardt M. de

doi:10.1016/j.farmac.2004.11.009

Cited by 39 publications

(17 citation statements)

References 11 publications

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“…The higher contents of the polymer increased in viscosity of polymeric solution producing smaller sized microcapsules. These findings are consistent with that reported earlier (Sanghvi, Nairn, 1991;Song et al, 2005). However, in formulations containing plasticizer (F4 to F15), the particle size increase (Table II) with the concentration of the plasticizer.…”

Section: Resultssupporting

confidence: 83%

Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules

Hussain

Mumtaz²,

Arshad

et al. 2016

Braz. J. Pharm. Sci.

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The present study describes the development of theophylline microcapsules by a non-solvent addition method and the effect of plasticizer addition on microencapsulation. The release was studied in distilled water and the data were analysed by various mathematical models for determining the mechanism of release. Prepared microcapsules were found to be spherical, free flowing and having more than 80% entrapped drug. The polymer -cellulose acetate phthalate and plasticizer -polyethylene glycol was considered to be affecting the properties of microcapsules including drug release (time for 50% drug release, T 50 ). The formulation with the highest proportion of polymer and without plasticizer (F3) showed the slowest release with T 50 = 4.3 h, while the formulation with lower proportion of polymer and 20% (w/w) plasticizer (F13 &14) showed the fastest release of drug with T 50 values of 1.2 h and 1.3 h, respectively. The drug release from most of the formulations was found to be following Higuchi model. It is concluded from the results of the present study that cellulose acetate phthalate significantly affects the sustained release of the drug in water, whereas the addition of polyethylene glycol slightly enhances the drug release.Uniterms: Theophylline/microcapsules. Microencapsulation. Cellulose acetate phthalate. Polyethylene glycol. Microcapsules/mechanism of release. Drugs/release. O presente estudo descreve o desenvolvimento de microcápsulas de teofilina pelo método sem adição de solvente e o efeito da adição de plastificante na microencapsulação. A liberação foi estudada em água destilada e os dados foram analisados por vários modelos matemáticos para determinação do mecanismo de liberação. As microcápsulas preparadas mostraram-se esféricas, livres de corrente e com mais de 80% de fármaco encapsulado. O polímero -ftalato de acetato de celulose e o plastificante -polietileno glicol -afetaram as propriedades das microcápsulas, incluindo a liberação do fármaco (tempo para liberação de 50% do fármaco, T 50 ). A formulação com a maior proporção de polímero e sem plastificante (F3) se mostrou como a de liberação mais lenta, com T 50 = 4,3 h, enquanto as formulações com menor proporção de polímero e 20% de plastificante (m/m) (F13 &14) apresentaram a liberação mais rápida do fármaco, com T 50 de 1,2 h e 1,3 h, respectivamente. A liberação do fármaco para a maioria das formulações seguiu o modelo de Higuchi. Concluiu-se, dos resultados do presente estudo, que o ftalato do acetato de celulose afeta significativamente a liberação controlada do fármaco em água, enquanto que a adição de polietileno glicol aumenta ligeiramente a liberação do fármaco.Unitermos: Teofilina/microcápsulas. Microencapsulação. Ftalato de acetato de celulose. Polietilenoglicol. Microcápsulas/mecanismo de liberação. Fármacos/liberação.

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Section: Resultssupporting

confidence: 83%

Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules

Hussain

Mumtaz²,

Arshad

et al. 2016

Braz. J. Pharm. Sci.

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“…Pore inducers are hydrophilic powders that can be added during the formulation of microspheres to obtain a desirable release of active ingredients; they are liable to drain water from the dissolution medium either by osmotic effect like sucrose or by their adsorbing and disintegrant effect like pregelatinized starch (34).…”

Section: Study Of the Effect Of Pore Inducers On The Release Profile mentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery

2011

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Abstract. Hydroxyzine HCl is used in oral formulations for the treatment of urticaria and atopic dermatitis. Dizziness, blurred vision, and anticholinergic responses, represent the most common side effects. It has been shown that controlled release of the drug from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. Therefore, the aim of the present study was to produce an effective drug-loaded dosage form that is able to control the release of hydroxyzine hydrochloride into the skin. The Microsponge Delivery System is a unique technology for the controlled release of topical agents, and it consists of porous polymeric microspheres, typically 10-50 μm in diameter, loaded with active agents. Eudragit RS-100 microsponges of the drug were prepared by the oil in an oil emulsion solvent diffusion method using acetone as dispersing solvent and liquid paraffin as the continuous medium. Magnesium stearate was added to the dispersed phase to prevent flocculation of Eudragit RS-100 microsponges. Pore inducers such as sucrose and pregelatinized starch were used to enhance the rate of drug release. Microsponges of nearly 98% encapsulation efficiency and 60-70% porosity were produced. The pharmacodynamic effect of the chosen preparation was tested on the shaved back of histamine-sensitized rabbits. Histopathological studies were driven for the detection of the healing of inflamed tissues.

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“…It is commonly assumed that the microparticles' surface area is the major factor influencing drug release from matrix microparticles 11,12 . This is in contrast to a previous report by our group which showed that reducing the size of Eudragit S microparticles by two thirds did not alter prednisolone release in the acidic medium 13 .…”

Section: Introductionmentioning

confidence: 99%

Inhibiting the Gastric Burst Release of Drugs from Enteric Microparticles: The Influence of Drug Molecular Mass and Solubility

Alhnan

Cosi

Murdan

et al. 2010

Journal of Pharmaceutical Sciences

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Effect of Viscosity and Concentration of Wall Former, Emulsifier and Pore-Inducer on the Properties of Amoxicillin Microcapsules Prepared by Emulsion Solvent Evaporation

Cited by 39 publications

References 11 publications

Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules

Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules

In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery

Inhibiting the Gastric Burst Release of Drugs from Enteric Microparticles: The Influence of Drug Molecular Mass and Solubility

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