Effect of virtual reality-based exercise intervention on sleep quality in children with acute lymphoblastic leukemia and healthy siblings: A randomized controlled trial

Tanrıverdi, Müberra; Çakır, Erkan; Akkoyunlu, Muhammed Emin; Cakir, Fatma Betul

doi:10.1017/s1478951522000268

Cited by 8 publications

(9 citation statements)

References 31 publications

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“…The population’s age ranged from 3 years to over 70 years. Among all studies, 16% (4/25) reported pediatric cancer patients aged <18 years, who were mainly diagnosed with leukemia, lymphoma, or brain cancer [ 37 , 42 , 50 , 52 ]. The remaining 84% (21/25) of studies reported adults with various cancers, including breast cancer, leukemia, lymphoma, brain cancer, nervous system cancer, lung cancer, gastrointestinal tract cancer, abdominal and pelvic cancer, oropharyngeal cancer, multiple myeloma, colorectal cancer, melanoma, bladder cancer, prostate cancer, pancreatic cancer, and ovarian cancer.…”

Section: Resultsmentioning

confidence: 99%

“…In addition to postmastectomy syndromes, other types of CRDs could also be intervened effectively by VRER. Studies showed that VRER can improve limb function, joint ROM, edema rates, cognition, respiratory disturbance index, apnea, ADLs, and QoL in cases of CRDs like CRCI, CIPN, and cancer-related sleep disorder [ 38 - 40 , 43 - 45 , 48 , 50 - 52 , 54 , 55 ]. The potential mechanism was speculated to be closely related to the virtualization and interaction of VR.…”

Section: Discussionmentioning

confidence: 99%

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Virtual Reality–Based Exercise Rehabilitation in Cancer-Related Dysfunctions: Scoping Review

Su,

Zhang,

Lian

et al. 2024

J Med Internet Res

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Background Virtual reality–based exercise rehabilitation (VRER) is a promising intervention for patients with cancer-related dysfunctions (CRDs). However, studies focusing on VRER for CRDs are lacking, and the results are inconsistent. Objective We aimed to review the application of VRER in patients with CRDs. Methods This scoping review was conducted following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist framework. Publications were included from the time of database establishment to October 14, 2023. The databases were PubMed, Embase, Scopus, Cochrane, Web of Science, ProQuest, arXiv, IEEE Xplore, MedRxiv, CNKI, Wanfang Data, VIP, and SinoMed. The population included patients with cancer. A virtual reality (VR) system or device was required to be provided in exercise rehabilitation as an intervention. Eligible studies focused on VRER used for CRDs. Study selection and data extraction were performed by 2 reviewers independently. Extracted data included authors, year, country, study type, groups, sample size, participant age, cancer type, existing or potential CRDs, VR models and devices, intervention programs and durations, effectiveness, compliance, satisfaction, and safety. Results We identified 25 articles, and among these, 12 (48%) were randomized clinical trials, 11 (44%) were other experimental studies, and 2 (8%) were observational studies. The total sample size was 1174 (range 6-136). Among the 25 studies, 22 (88%), 2 (8%), and 1 (4%) included nonimmersive VR, immersive VR, and augmented reality, respectively, which are models of VRER. Commercial game programs (17/25, 68%) were the most popular interventions of VRER, and their duration ranged from 3 to 12 weeks. Using these models and devices, VRER was mostly applied in patients with breast cancer (14/25, 56%), leukemia (8/25, 32%), and lung cancer (3/25, 12%). Furthermore, 6 CRDs were intervened by VRER, and among these, postmastectomy syndromes were the most common (10/25, 40%). Overall, 74% (17/23) of studies reported positive results, including significant improvements in limb function, joint range of motion, edema rates, cognition, respiratory disturbance index, apnea, activities of daily living, and quality of life. The compliance rate ranged from 56% to 100%. Overall, 32% (8/25) of studies reported on patient satisfaction, and of these, 88% (7/8) reported satisfaction with VRER. Moreover, 13% (1/8) reported mild sickness as an adverse event. Conclusions We found that around half of the studies reported using VRER in patients with breast cancer and postmastectomy dysfunctions through nonimmersive models and commercial game programs having durations of 3-12 weeks. In addition, most studies showed that VRER was effective owing to virtualization and interaction. Therefore, VRER may be an alternate intervention for patients with CRDs. However, as the conclusions were drawn from data with acknowledged inconsistencies and limited satisfaction reports, studies with larger sample sizes and more outcome indictors are required.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Virtual Reality–Based Exercise Rehabilitation in Cancer-Related Dysfunctions: Scoping Review

Su,

Zhang,

Lian

et al. 2024

J Med Internet Res

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“…Regarding dropouts, 12 studies reported a rate of less than 20%, and 5 studies had 26.2% to 60% dropouts. The dropout rate was reduced by session supervision; supervised interventions had an 11.1% dropout rate [33,[37][38][39][40]46,48,50,54] compared with 25.4% for those without supervision [34,35,41,42,44,47,[51][52][53]. The dropout rate increased with age [41,43,44,46,47,50,52], male gender [50,51], and cancer aggressiveness [44,46,47,52,53].…”

Section: Feasibility and Adherence To Exergaming Interventionsmentioning

confidence: 99%

Effects of Active Video Games in Patients With Cancer: Systematic Review

Peyrachon,

Rébillard

2023

JMIR Cancer

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Background Physical activity (PA) is now considered an adjuvant therapy in cancer treatment; nevertheless, multiple barriers could reduce PA engagement during treatment. Active video games (AVGs) lead to the achievement of mild- to moderate-intensity PA and represent a promising tool for regular movement and exercise. Objective This paper aims to review the current literature and provide updated content on the physiological and psychological effects of AVG-based interventions in patients with cancer undergoing treatment. Methods Four electronic databases were investigated. Studies reporting on AVG interventions delivered to patients undergoing treatment were included. A total of 21 articles (17 interventions) were identified for data extraction and quality assessment. Results A total of 362 patients with cancer participated in the studies (number of participants 3-70). The majority underwent treatment for breast, lung, prostate, hematologic, or oral or laryngeal cancer. The types and stages of cancer varied in all studies. Participants ranged in age from 3 to 93 years. Four studies included patients with pediatric cancer. The duration of interventions ranged from 2 to 16 weeks, with a minimum of 2 sessions per week and a maximum of 1 daily session. Sessions were supervised in 10 studies, and 7 included home-based interventions. AVG interventions improved endurance, quality of life, cancer-related fatigue, and self-efficacy. Effects were mixed on strength, physical function, and depression. AVGs did not affect activity level, body composition, or anxiety. Compared with standard physiotherapy, physiological effects were lower or similar, and psychological effects were higher or similar. Conclusions Overall, our results suggest that AVGs can be recommended to patients undergoing cancer treatment, given the physiological and psychological benefits. When AVGs are proposed, supervision of the sessions should be considered as it can limit dropouts. In the future, it is important to develop AVGs that combine endurance and muscle strengthening, with the possibility of achieving moderate to high exercise intensity, depending on the physical abilities of the patients, as indicated in the World Health Organization’s recommendations.

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“…Due to the current technological evolution and children's ability to interact with these devices, recent evidence suggested the use of VR as an effective non-pharmacological intervention in pediatrics, because the inclusion of "gamification" (game elements in educational context) allows children a distraction due to their immersion in virtual play [14,[26][27][28][29][30][31][32]. Actually, VR was tested as an effective method in the management of pain and anxiety of children in oncologic, medical, surgical, and community settings (i.e., during vaccination procedures) [14,23,27,30].…”

Section: Introductionmentioning

confidence: 99%

“…Actually, VR was tested as an effective method in the management of pain and anxiety of children in oncologic, medical, surgical, and community settings (i.e., during vaccination procedures) [14,23,27,30]. The significant impact of VR on supportive care management and quality of life enhancement of pediatric patients with cancer is well established [9,32,33].…”

Section: Introductionmentioning

confidence: 99%

Immersive and Non-Immersive Virtual Reality for Pain and Anxiety Management in Pediatric Patients with Hematological or Solid Cancer: A Systematic Review

Comparcini

Simonetti

Galli

et al. 2023

Cancers

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Invasive and painful procedures, which often induce feelings of anxiety, are necessary components of pediatric cancer treatment, and adequate pain and anxiety management during these treatments is of pivotal importance. In this context, it is widely recognized that a holistic approach, including pharmacological and non-pharmacological modalities, such as distraction techniques, should be the standard of care. Recent evidence suggested the use of virtual reality (VR) as an effective non-pharmacological intervention in pediatrics. Therefore, this systematic review aims to analyze previously published studies on the effectiveness of VR for the management of pain and/or anxiety in children and adolescents with hematological or solid cancer. Medline, SCOPUS, Web of Science, ProQuest, CINAHL, and The Cochrane Central Register of Controlled Trials were used to search for relevant studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Randomized controlled trial, crossover trial, cluster randomized trial, and quasi-experimental studies were included. Thirteen studies, published between 1999 and 2022, that fulfilled the inclusion criteria were included. Regarding the primary outcomes measured, pain was considered in five studies, anxiety in three studies, and the remaining five studies analyzed the effectiveness of VR for both pain and anxiety reduction. Our findings suggested a beneficial effect of VR during painful vascular access procedures. Limited data are available on the reduction of anxiety in children with cancer.

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Effect of virtual reality-based exercise intervention on sleep quality in children with acute lymphoblastic leukemia and healthy siblings: A randomized controlled trial

Cited by 8 publications

References 31 publications

Virtual Reality–Based Exercise Rehabilitation in Cancer-Related Dysfunctions: Scoping Review

Virtual Reality–Based Exercise Rehabilitation in Cancer-Related Dysfunctions: Scoping Review

Effects of Active Video Games in Patients With Cancer: Systematic Review

Immersive and Non-Immersive Virtual Reality for Pain and Anxiety Management in Pediatric Patients with Hematological or Solid Cancer: A Systematic Review

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