Effect of virgin fatty oil of <i>Pistacia lentiscus</i> on experimental burn wound’s healing in rabbits.

Abstract

This study aimed to assess the efficiency of the virgin fatty oil of Pistacia lentiscus (PLVFO) for burn wounds healing. It was carried out on 6 adult male New Zealand rabbits. Four burn wounds of deep third degree were made on the back of each animal. The first was not treated and served as control (CRL group); the others were covered immediately after burning procedure by 0.5g of one of the following products: Vaseline gel (VAS group), Madecassol ® cream 1% (MAD group) or 1ml of PLVFO (PLVFO group). The treatments were repeated once daily until complete healing. For four days post burns, the percentage of wound contraction was assessed. Also, the different healing times were noted. The results showed that both PLVFO and Madecassol ® significantly accelerated wound healing activity compared to wounds dressed with Vaseline and the untreated wounds. However, the level of wound contraction was significantly higher and the healing time was faster in PLVFO group than those of the MAD group, VAS group and CRL group. The different epithelization periods obtained in days were respectively: 30±3.94 (PLVFO group), 33.5±3.78 (MAD group), 34.66±3.88 (VAS group) and 37.16±3.54 (CRL group). We conclude that Pistacia lentiscus virgin fatty oil promotes significantly (p< 0.05) wound contraction and reduces epithelization period in rabbit model.

The evaluation of the healing proprieties of pumpkin and linseed oils on deep second-degree burns in rats

“…The untreated group showed a slower epithelialization and wound contraction than the groups treated with the reference drug and the tested oils. The quantitative evaluation of the percentage of burn wound contraction proved that the wound-burns of the treated groups were significantly reduced compared with the wound-burns of the untreated group (Djerrou et al, 2010). The general wound-healing dynamics for the three treated groups suggest an acceleration of the healing process due to different principle applications.…”

Oxidative stress-related liver dysfunction by sodium arsenite: Alleviation byPistacia lentiscusoil

“…The liquids were then separated by decantation. At the end of this phase, virgin Pistacia lentiscus oil was produced (Djerrou et al, 2010).…”

“…The dose of NaAsO 2 and the period of treatment were selected on the basis of previous studies (Pal & Chatterjee, 2004;Yousef et al, 2008), whereas Pistacia lentiscus oil dose was selected from previous studies on experimental animals (Boukeloua et al, 2012;Djerrou et al, 2010Djerrou et al, , 2011. All experimental procedures were carried out according to the National Institute of Health Guidelines for Animal Care and approved by the Ethics Committee of the University.…”

“…Pistacia lentiscus is also effective in the treatment of functional dyspepsia and gastric ulcer (Dabos et al, 2010) as well as in the healing of burns (Djerrou et al, 2010). Because of its special taste, since antiquity Pistacia lentiscus has been extensively used in the Mediterranean and Middle Eastern countries as food/beverages flavouring additive and also as a traditional remedy without any reported toxicity (Attoub et al, 2014;Moulos et al, 2009).…”

Irritantcy potential and sub acute dermal toxicity study of <i>Pistacia Lentiscus</i> fatty oil as a topical traditional remedy

“…In Eastern Algeria, some families used this fatty oil traditionally to treat respiratory disorders, stomach aches, dermal burns, lombalgies and varicose veins. We have proved scientifically, in a previous study, that this oil stimulates the cicatrizing process in rabbit model (Djerrou et al, 2010). When applied daily for a six consecutive weeks via rectal route in New Zealand rabbits, the oil was proven to be safe with no adverse effects on liver and kidney functions (Djerrou et al ,…”