Effect of vigabatrin on the pharmacokinetics of carbamazepine

Sánchez-Alcaraz, A.; Quintana, M B; López, Emilio Cuesta; Rodríguez, I. Marcelino; Llopis, Paula García

doi:10.1046/j.1365-2710.2002.00441.x

Cited by 16 publications

(3 citation statements)

References 7 publications

(4 reference statements)

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“…VB mainly relies on renal elimination and it does not need binding plasma proteins [192] or metabolism [193]. When patients with epilepsy were co-treated VB with other AEDs, VB might cause a significant increase in plasma clearance of CBZ [194] and decrease in the serum PT concentration [195]. VB is effective in the treatment of pediatric patients with infantile spasms, infantile spasms secondary to tuberous sclerosis, refractory complex partial seizures, and adult patients with LGS [196].…”

Section: New Generation Aedsmentioning

confidence: 99%

The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism

Fan

Lee

Chang

et al. 2016

IJMS

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Epilepsy is a common neurological disorder worldwide and anti-epileptic drugs (AEDs) are always the first choice for treatment. However, more than 50% of patients with epilepsy who take AEDs have reported bone abnormalities. Cytochrome P450 (CYP450) isoenzymes are induced by AEDs, especially the classical AEDs, such as benzodiazepines (BZDs), carbamazepine (CBZ), phenytoin (PT), phenobarbital (PB), and valproic acid (VPA). The induction of CYP450 isoenzymes may cause vitamin D deficiency, hypocalcemia, increased fracture risks, and altered bone turnover, leading to impaired bone mineral density (BMD). Newer AEDs, such as levetiracetam (LEV), oxcarbazepine (OXC), lamotrigine (LTG), topiramate (TPM), gabapentin (GP), and vigabatrin (VB) have broader spectra, and are safer and better tolerated than the classical AEDs. The effects of AEDs on bone health are controversial. This review focuses on the impact of AEDs on growth and bone metabolism and emphasizes the need for caution and timely withdrawal of these medications to avoid serious disabilities.

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Section: New Generation Aedsmentioning

confidence: 99%

The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism

Fan

Lee

Chang

et al. 2016

IJMS

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“…Mono-therapeutic treatment of epilepsy using a conventional antiepileptic drug carbamazepine has been reported to have prominent adverse effects especially on testicular functions (13). Vigabatrin is a newer antiepileptic which is used as an adjunct therapy in the treatment of epilepsy (14). However, reports on the combination of these drugs on reproductive functions have not been reported and need to be investigated, hence this study.…”

Section: Introductionmentioning

confidence: 99%

Effects of vigabatrin, carbamazepine or its combination on the pituitarygonadal axis in male Wistar rats

.¹,

Owolabi²,

Adeyeye³

et al. 2018

Research Journal of Health Sciences

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Objectives: Epilepsy is the most common non-infectious neurologic disease in developing African countries following stroke and Alzheimer's disease. Most conventional antiepileptic drugs, due to their centrally acting potentials have been implicated in the deregulation of reproductive hormones. This study assessed the effect of the single and combined administration of vigabatrin (VIG) and carbamazepine (CBZ) on the pituitary-gonadal axis of male Wistar rats.Methods: Fifty male Wistar rats were randomly divided into 5 groups (n=10). The animals were administered with distilled water (0.1 ml/kg/day), VIG (200 mg/kg/day), CBZ (200 mg/kg/day), VIG-CBZ combination (100 mg/kg/day each) and VIG-CBZ combination (200 mg/kg/day each) for 8 weeks. Twenty-four hours after the last dose, 5 rats from each group were sacrificed, while the remaining 5 eventually sacrificed after another 8 week of drug withdrawal. The level of luteinizing hormone, follicle stimulating hormone and testosterone were determined from the serum. The weight of the reproductive organs and sperm indices were assayed, while the testicular tissue were examined for signs of histological alteration. Results:The results showed significant decrease in the levels of luteinizing hormone, follicle stimulating hormone, testosterone and sperm physiological indices. Morphological alteration was noticed in the testes of all the treated rats. However, there was restoration of these parameters sequelae to 8 weeks cessation of treatment. Conclusion:Single and combined administration of VIG and CBZ resulted into pituitary-gonadal axis hormonal deregulation and alterations in the sperm profile which were however reversible upon cessation of treatment.

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“…VGB is usually administered at doses ranging from 1.5 to 4 g/day [4]; it is well absorbed after an oral dose and its half-life time is about 5-8 h [5]. Plasma levels at steady-state are in the 10-100 mg/mL range, with the most frequent concentrations in the 20-60 mg/mL range [6]. About 50% of the patients experience adverse effects when treated with VGB.…”

Section: Introductionmentioning

confidence: 99%

Determination of vigabatrin in human plasma by means of CE with LIF detection

et al. 2007

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A method has been developed for the quantitation of the antiepileptic drug vigabatrin (VGB) in human plasma. It is based on CE with LIF detection. The effect of the pH of the buffer and of N-methylglucamine (GLC) as BGE constituent was investigated. The final BGE consisted of 50 mM borate buffer, pH 9.0, with 100 mM GLC and enabled separation within 12 min at 20 kV voltage. An SPE procedure was used for the pretreatment of biological samples, based on mixed-mode lipophilic-cation exchange cartridges, followed by a derivatization step with 6-carboxyfluorescein-N-succinimidyl ester (CFSE). Fluorescence was excited by an Ar-ion laser (lambda(exc) = 488 nm). Linearity was observed in the 10-120 microg/mL plasma concentration range. Extraction yield was >96%, precision (expressed as RSD) <6.7% and accuracy (recovery) was between 97.0 and 101.6%. The method has been successfully applied to the analysis of VGB in plasma of epileptic patients undergoing therapy with the drug.

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Effect of vigabatrin on the pharmacokinetics of carbamazepine

Abstract: Vigabatrin produced a statistically significant increase in the plasma clearance of carbamazepine when the two drugs were given simultaneously.

Cited by 16 publications

References 7 publications

The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism

The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism

Effects of vigabatrin, carbamazepine or its combination on the pituitarygonadal axis in male Wistar rats

Determination of vigabatrin in human plasma by means of CE with LIF detection

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