Effect of vesicoureteral reflux on renal function in children with recurrent urinary tract infections

Aperia, Anita; Broberger, O.; Ericsson, N. O.; Wikstad, I.

doi:10.1038/ki.1976.51

Cited by 34 publications

(8 citation statements)

References 18 publications

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“…Not even when the GFR of individual kidneys was calculated was a relation to grade of VUR found. These results seem to contradict those of Aperia et al 16 who studied GFR by separate clearance technique in 22 girls with recurrent UTI, most of whom had a gross, unilateral VUR. Renal function was unaffected when VUR was moderate, small, or non-existent.…”

Section: Methodscontrasting

confidence: 69%

Age as a main determinant of renal functional damage in urinary tract infection.

Berg¹,

Johansson²

1983

Archives of Disease in Childhood

112

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SUMMARY Renal function was studied in 61 girls suffering from recurrent urinary tract infections, with at least one febrile infection. Clearance of inulin was determined. Intravenous urography and micturating cystourethrography were performed 1-6 months after the first infection and 0-6 months before or after the function test. A lowglomerular filtration rate(GFR) was found onlyamong children with their first pyelonephritis before the age of 3 years. A low GFR was found mostly in patients with small or scarred kidneys but was also seen in a few patients with normal intravenous urographs. Low GFR as well as radiologically small kidneys at the time of the function test were found independently of the presence or grade of vesicoureteral reflux at first infection. Patients with early onset pyelonephritis (before age 3 years) had a low capacity for early compensatory hypertrophy in contrast to patients with late onset pyelonephritis.

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Section: Methodscontrasting

confidence: 69%

Age as a main determinant of renal functional damage in urinary tract infection.

Berg¹,

Johansson²

1983

Archives of Disease in Childhood

112

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“…The observations from natural history studies that the severity of VUR and the presence of intrarenal reflux are the most important determining factors as to whether renal damage or dys function will occur have been major advances in the under standing of this renal lesion [3,4,[15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…There is now considerable evidence that gross vesicoureteric reflux (VUR) is the essential pathogenetic factor in the etiology of the small, scarred, contracted kidney of non-obstructive, atrophic, chronic pyelonephritis [1][2][3][4]. For this reason reflux nephropathy (RN) was suggested [1] as a more appropriate term for this entity.…”

Section: Introductionmentioning

confidence: 99%

End-Stage Reflux Nephropathy

Bailey¹

1981

Nephron

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Gross vesico-ureteric reflux is the essential pathogenetic factor in the etiology of the small, scarred kidney of non-obstructive, chronic pyelonephritis (reflux nephropathy). 18 (12.5%) of 144 patients entering a dialysis-transplant programme had end-stage reflux nephropathy. The majority of patients initially presented with severely impaired renal function, hypertension and significant proteinuria. Documented urinary tract infections had only occurred in one-third of the patients. 8 of the 12 women presented during a pregnancy, usually with a presentation resembling toxaemia of pregnancy. Reflux nephropathy is a significant cause of end-stage chronic renal failure.

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“…Reflux nephropathy has been shown to be associated with significant renal tubular dysfunction [1,6]. Renal tubular damage mediated by VUR may be manifested by increased levels of renal tubular enzymes.…”

Section: Introductionmentioning

confidence: 99%

Urinary beta2-microglobulin as a marker for vesicoureteral reflux

Assadi

1996

Pediatr Nephrol

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To determine whether urinary beta 2-microglobulin (beta 2 M) excretion would be elevated in patients with severity of vesicoureteral reflux, urinary beta 2 M/creatinine (Cr) ratios were measured on random urine samples in 56 children with various grades of reflux. Results were compared with ratios of 39 nonrefluxing patients matched for age and gender. Patients with evidence of renal insufficiency or urinary tract infection were excluded. Bladder urine was obtained at the time of the vesicoureterogram. Reflux was graded using the International Reflux Classification System. The mean urinary beta 2 M/Cr ratio was higher in the refluxing group (1.82 +/- 0.6 micrograms/mg Cr) than in the nonrefluxing control group (0.54 +/- 0.09 microgram/mg Cr. P < 0.01). When the mean urinary beta 2 M/Cr ratios were compared for each grade of reflux with the nonrefluxing control group, patients with grade IV and V reflux had significantly higher urinary beta 2 M/Cr values than the nonrefluxing patients (2.83 +/- 0.71 micrograms/mg Cr and 4.61 +/- 0.65 micrograms/mg Cr, P < 0.001, respectively). No patient with grade I, II, or III reflux had a urinary beta 2 M/Cr ratio above 0.92 microgram/mg Cr. Statistical analysis revealed no significant differences among the mean beta 2 M/Cr ratio for grade I (0.53 +/- 0.08), II (0.51 +/- 0.09), or III (0.59 +/- 0.17) refluxers or the nonrefluxing controls. Therefore, urinary beta 2 M/Cr ratios are increased in children with a high grade of reflux. Such values may be useful in the early detection of tubular damage in patients with vesicoureteral reflux.

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Effect of vesicoureteral reflux on renal function in children with recurrent urinary tract infections

Cited by 34 publications

References 18 publications

Age as a main determinant of renal functional damage in urinary tract infection.

Age as a main determinant of renal functional damage in urinary tract infection.

End-Stage Reflux Nephropathy

Urinary beta2-microglobulin as a marker for vesicoureteral reflux

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