“…Indeed, when molecules such as angiostatin Mauceri et al, 1998), endostatin (Hanna et al, 2000) or neutralising anti-human VEGF 165 antibodies (Gorski et al, 1999;Lee et al, 2000) are administered together with ionising radiation, the cytotoxic effects of the latter upon endothelial cells are potentiated in vivo, resulting in an enhanced antitumoral effect. Likewise, when radiotherapy is combined with the administration either of antibodies against VEGFR-2 or of the antiangiogenic compound TNP-470, the growth-retarding effects of radiation is potentiated (Teicher et al, 1996;Lund et al, 2000;Hess et al, 2001;Kozin et al, 2001).…”