Effect of Vedic music on steroidogenic gene expression in 3D‐cultured buffalo granulosa cell spheroids model system, a pilot study

Abstract

Music is known for reducing stress, anxiety and depression, improving cognitive performance, and enhancing oestrogen levels. However, its effect on non‐auditory mammalian cell system and the molecular events leading to higher oestrogen levels is less explored. Therefore, the present study targeted to know the direct effects of a peaceful Vedic music on 3D cultured buffalo granulosa cell spheroids. The spheroids were daily exposed to the Mahamrityunjaya mantra, a kind of Vedic chants, for 1.5 hr for 6 days. After 6 days, the music effect was analysed by the expression analysis of steroidogenic (CYP19A1, STAR and HSD17β1) and proliferative marker (PCNA) genes. Interestingly, the CYP19A1 gene expression was significantly upregulated by 3.464 ± 0.15 folds in the music exposed spheroids than the non‐exposed spheroids. However, the expression of other steroidogenic and proliferative genes was unaltered. These observations provided a transcriptional clue for higher estradiol levels by the music and a scope to use Vedic chants for increasing the CYP19A1 expression to help tackle some pathophysiological conditions.

The Effects of Sounds and Music on Cells and Organisms: A Promising and Developing Area of Research

“…It has been shown that Indian Vedic music can upregulate the expression of steroidogenic genes in 3D cultured buffalo granulosa cell spheroids (Pandey et al 2021).…”

Untitled

“…It has been shown that Indian Vedic music can upregulate the expression of steroidogenic genes in 3D cultured buffalo granulosa cell spheroids (Pandey et al 2021).…”

Increasing immunity to fight against novel COVID-19: Noninvasive public health approach

“…[ 3 ] However, recently group-level studies conducted by Indian researcher (2020) for mantra sounds have proven to increase immunity, reduce stress, and affect the expression analysis of steroidogenic ( CYP19A1 , STAR , and HSD17β1 ) and proliferative marker ( PCNA ) gene upregulation in short durations. [ 4 ]…”