Effect of vasopressin on proximal tubule sodium reabsorption in the dog

Bb, Davis; Knox, FG; Berliner, Robert W.

doi:10.1152/ajplegacy.1967.212.6.1361

Cited by 23 publications

(10 citation statements)

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“…The interpretation of the free water clearance experiments is based on the postulate that, in the absence of antidiuretic hormone, the clearance of free water is determined primarily by the volume of fluid that reaches the diluting segment of the nephron and this volume, in turn, by the glomerular filtration rate and fractional reabsorption by the proximal tubule. In the present experiments, the delivery of tubule fluid from the proximal tubule during water diuresis probably approximates that during hydropenia since fractional sodium reabsorption by the proximal tubule of the dog is not affected by infusion of 50 ml/kg of 2.5%o dextrose in water (12). Infusion of hyperoncotic albumin solution resulted in a significant increase in free water clearance, from a mean of 4.93 to 11.82 ml/100 ml GFR/min (P < 0.01).…”

Section: Discussionsupporting

confidence: 52%

Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis

Howards¹,

Davis²,

Knox³

et al. 1968

J. Clin. Invest.

104

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A B S T R A C T The effect of infusions of hyperoncotic solutions on fractional sodium reabsorption by the pro)imal tubule of the dog was studied by the recollection micropuncture method. Tubule fluid to plasma inulin concentration ratios were measured for identified proximal tubule segments before and after infusion of 25%o albumin or dextran solutions. Results were compared with changes in fractional reabsorption during saline diuresis. Plasma volume increased 66% + SE 5.8 after infusion of albumin solution and 94% + SE 8.2 after infusion of dextran solution. Fractional sodium reabosorption by the proximal tubule was depressed after infusion of both of these hyperoncotic solutions. Nevertheless, changes in sodium excretion after infusion of albumin and dextran were small. In contrast, after infusions of isotonic sodium chloride solution, which increased plasma volume 61 % + SE 5.8, a decrease in fractional reabsorption of 50.7%o + SE 7.2 was associated with large changes in sodium excretion.

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Section: Discussionsupporting

confidence: 52%

Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis

Howards¹,

Davis²,

Knox³

et al. 1968

J. Clin. Invest.

104

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“…The reasons for the variable blood pressure changes after vasopressin are unknown, but they may represent differences' in individual responsiveness to the given dose of vasopressin. An inhibitory effect of vasopressin on proximal tubule sodium reabsorption has not been demonstrated previously (4)(5)(6). The earlier micropuncture studies were carried out because there may be stimulation of sodium transport by vasopressin as suggested by toad bladder studies (14), but such a stimulatory effect could not be shown except in the isolated collecting tubules (15).…”

Section: Resultsmentioning

confidence: 97%

“…Because of the concomitant phosphaturia, they concluded that vasopressin exerts natriuresis by stimulating the production of cyclic AMP in the proximal tubule of the kidney, thereby reducing its sodium and phosphate reabsorption. On the other hand, the available micropuncture studies in the literature (4)(5)(6) failed to demonstrate any effect of vasopressin on proximal tubule sodium transport in the animals undergoing water diuresis. Our present micropuncture study was undertaken to reexamine whether proximal tubule transport of sodium and phosphate could be altered in thyroparathyroidectomized (TPTX) dogs by administration of vasopressin in the doses frequently employed in experimental conditions.…”

Section: Introductionmentioning

confidence: 95%

The effect of vasopressin on phosphate transport in the proximal tubule of the dog.

Wen

1974

J. Clin. Invest.

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“…In dogs and rats vasopressin does not alter the water permeability of 85 86 A.M. BEAL the proximal convoluted tubule (Clapp, Watson & Berliner, 1963;Gertz, Kennedy & Ullrich, 1964;UWrich, Rumrich & Fuchs, 1964) or the loop of Henle (Wirz, 1956;Gottschalk, 1961;Morgan & Berliner, 1968). Likewise Davis, Knox & Berliner (1967) found no evidence of sodium reabsorption in the proximal tubule being altered by vasopressin although some earlier reports suggest that vasopressin might stimulate sodium reabsorption in this segment (Clapp et al, 1963;Gottschalk, cited by Gertz et aL, 1964). In the rat various lines of evidence indicate that the distal convoluted tubule is one site of action of vasopressin on water reabsorption (Wirz, 1956;Gottschalk & Mylle, 1959;Darmady, Durant, Matthews & Stranack, 1960) but in other species such as dog, monkey and Meriones the distal tubule does not show the same responsiveness to the hormone (Clapp & Robinson, 1966;Bennett, Brenner & Berliner, 1968;Rouffignac, Lechene, Guinnebault & Morel, 1969).…”

Section: Discussionmentioning

confidence: 99%

The Effect of High Rates of Vasopressin Administration on Renal Potassium and Sodium Excretion During Potassium Loading in the Sheep

Beal

1976

British J Pharmacology

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1The influence of potassium loading on the renal excretion of sodium, potassium and solute during high rate vasopressin administration has been investigated in sheep.2 Adrenalectomized sheep were infused with 0.43 M KCI at 2 mI/min for 2-2.5 hours. Coincident with the rise in plasma potassium concentration, the urinary excretion of sodium, potassium, solute and water was increased as was the reabsorption of solute-free water. The rates of urinary excretion of sodium and potassium, osmolal clearance (Cosm) and solute-free water reabsorption (TCH20) for the first 50 min of potassium infusion were each found to be linearly related to the plasma potassium concentration. 3 After 50 min an infusion of vasopressin at 1 or 4 mu/min was superimposed on the potassium infusion for a period of 30 minutes. The administration of vasopressin was consistently associated with further augmentation of potassium excretion and clearance, of osmolal clearance and of solute-free water reabsorption to values above those anticipated from the pre-vasopressin regression lines for these parameters. Urinary sodium showed a coincident depression in the rate of excretion and clearance during the same period. 4 Thirty to fifty minutes after the cessation of vasopressin infusion the potassium and sodium excretions had returned to values which approximated the pre-vasopressin relations between plasma potassium and the urinary excretions of these ions. 5Both rates of vasopressin infusion were equally effective in increasing the potassium clearance. Any differences in clearance between the two rates of vasopressin administration were not statistically significant. 6 The large increments in potassium excretion (averaging > 40%) were interpreted as indicating that, when vasopressin is present at high concentrations, the distal tubule is one site of action of the hormone in the nephron of sheep.

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Effect of vasopressin on proximal tubule sodium reabsorption in the dog

Cited by 23 publications

References 0 publications

Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis

Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis

The effect of vasopressin on phosphate transport in the proximal tubule of the dog.

The Effect of High Rates of Vasopressin Administration on Renal Potassium and Sodium Excretion During Potassium Loading in the Sheep

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