Effect of Vasopressin on Cardiovascular and Renal Functions and ANP Release under Plasma Volume Expansion.

Ohta, Makoto; Kimura, Tokihisa; Ota, Kozo; Miyake, Shoji; Inoue, Minoru; Sato, Kazutoshi; Yamamoto, Takeki; Yoshinaga, Kaoru

doi:10.1620/tjem.165.115

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…It is well known that increases in left and/or right atrial stretch exerted by increased blood pressure in response to pressor hormones (14,21,22), to increased central venous pressure associated with the plasma volume expansion (21,23,24) and to tachycardia stimulate the release of ANH (25,26). In the present study, the blood pressure and heart rate never changed in response to hypertonic saline or dextran hypertonic saline, regardless of the presence or absence of the vagal nerve.…”

Section: Discussionsupporting

confidence: 41%

Role of vagal nerves and atrial natriuretic hormone in vasopressin release and a diuresis under hypertonic volume expansion

Sato

Kimura²,

Ota³

et al. 1993

Acta Endocrinologica

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of vagal nerves and atrial natriuretic hormone in vasopressin release and a diuresis under hypertonic volume expansion. Acta Endocrinol 1993:129:65-74. ISSN 0001-5598To assess whether increases in circulating atrial natriuretic hormone (ANH) in response to the plasma volume expansion, besides the volume receptor-mediated mechanisms, attenuate the arginine vasopressin (AVP) response to increased plasma osmolality and whether changes in plasma AVP and ANH affect renal solute excretion under hypertonic plasma volume expansion, hypertonic saline (0.95 mol/l saline) alone, hypertonic saline with 6% dextran (6D-HS) and hypertonic saline with 9% dextran (9D-HS) were administered into anesthetized dogs. In the control study, 0.15 mol/l NaCI alone was administered. Plasma AVP and ANH and cardiovascular and renal functions were determined.Hypertonic saline and 9D-HS also were administered into the vagotomized and sham operated dogs, and the same parameters were determined. Mean blood pressure and heart rate never changed in all the groups, but central venous pressure and plasma volume increased markedly in 6D-HS and 9D-HS groups. In the control and hypertonic saline groups, central venous pressure increased slightly but plasma volume never changed. Plasma AVP increased in the order of hypertonic saline, 6D-HS and 9D\ x=req-\ HS, but plasma ANH increased in reverse order. Vagotomy restored the AVP response to 9D-HS to 75% of its response to hypertonic saline, with a marked rise in plasma ANH. Urine sodium and potassium excretion and urine flow increased in hypertonic saline, 6D-HS and 9D-HS groups, but these increases were comparable among the groups. In the control group, these parameters never changed. These results suggest that the volume receptor-mediated vagal neural and ANH responses to the plasma volume expansion may have an effect on the suppression of the AVP response to osmotic stimuli, and increased plasma ANH release never potentiated the natriuresis under the hypertonic plasma volume expansion.It is well known that arginine vasopressin (AVP) plays an essential role in the regulation of body fluid metab¬ olism. The release of AVP is mainly regulated by the osmoreceptor, atrial volume receptor and aortic and carotid baroreceptors. Namely, a rise in plasma osmolality stimulates AVP release, but increased blood volume suppresses AVP release via the volume receptor and/or baroreceptor reflexes, which act via the afferent vagal and glossopharyngeal nerves (1-5). On the other hand, atrial natriuretic hormone (ANH), known to increase in response to the atrial stretch by the blood volume expansion (6), has been documented to interfere with AVP release (7-12) and AVP to stimulate ANH release (13-15).Thus, it is likely that the blood volume expansion may attenuate the AVP response to osmotic stimuli via both the volume receptor reflex and the increased plasma ANH. However, little is known about the mutual relationship between endogenous ANH release and the volume receptor reflex on AVP release under the hypertonic blood v...

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Section: Discussionsupporting

confidence: 41%

Role of vagal nerves and atrial natriuretic hormone in vasopressin release and a diuresis under hypertonic volume expansion

Sato

Kimura²,

Ota³

et al. 1993

Acta Endocrinologica

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“…Opposing to AVP effects on vascular smooth muscle and blood pressure, the release of atrial natriuretic peptide (ANP) results in a vasorelaxing effect and fall in cardiac output. Such a cross-talk between the two hormones is due to increased atrial distension that occurs in response to increased blood pressure (heart afterload), and increased central venous pressure and venous return (heart preload) [26].…”

Section: Introductionmentioning

confidence: 99%

Loop analysis of blood pressure/volume homeostasis

2019

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We performed a mathematical analysis of the dynamic control loops regulating the vasomotor tone of vascular smooth muscle, blood volume, and mean arterial pressure, which involve the arginine vasopressin (AVP) system, the atrial natriuretic peptide system (ANP), and the renin-angiotensin-aldosterone system (RAAS). Our loop analysis of the AVP-ANP-RAAS system revealed the concurrent presence of two different regulatory mechanisms, which perform the same qualitative function: one affects blood pressure by regulating vasoconstriction, the other by regulating blood volume. Both the systems are candidate oscillators consisting of the negative-feedback loop of a monotone system: they admit a single equilibrium that can either be stable or give rise to oscillatory instability. Also a subsystem, which includes ANP and AVP stimulation of vascular smooth muscle cells, turns out to be a candidate oscillator composed of a monotone system with multiple negative feedback loops, and we show that its oscillatory potential is higher when the delays along all feedback loops are comparable. Our results give insight into the physiological mechanisms ruling long-term homeostasis of blood hydraulic parameters, which operate based on dynamical loops of interactions.

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Clinical Relationship of Myocardial Sympathetic Nervous Activity to Cardiovascular Functions in Chronic Heart Failure: Assessment by Myocardial Scintigraphy with 123I-Metaiodobenzylguanidine

Wada

Miura

Fujiwara

et al. 2003

Tohoku J. Exp. Med.

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The aim of this study was to clarify the relationship between cardiac sympathetic nervous activity (SNA) assessed by radioiodinated metaiodobenzylguanidine (123I-MIBG), an analogue of norepinephrine and cardiovascular functions in patients with chronic heart failure (CHF). Subjects were 17 patients with CHF. A dose of 111 MBq of 123I-MIBG was administered intravenously, and 5-minute anterior planar images were obtained 15 minutes (early image) and 3 hours (delayed image) after the injection. The heart/mediastinum (H/M) count ratio was defined to quantify cardiac 123I-MIBG uptake. The washout ratio (WR) of 123I-MIBG from the heart was calculated as follows: (early counts-delayed counts)/early counts x 100 (%). Echocardiography was performed on all patients within 1 week of 123I-MIBG scintigraphy to measure stroke volume index (SVI). Blood pressure and heart rate (HR) in the resting state were also recorded to calculate cardiovascular functions including cardiac output, pulse pressure (PP), and mean blood pressure. Significant linear correlations were found between the early H/M ratio of 123I-MIBG and SVI, and between the delayed H/M ratio of 123I-MIBG and SVI, respectively. WR of 123I-MIBG was correlated with HR, and was inversely correlated with SVI and with PP, respectively. It is likely that a decrease in SVI is associated with enhanced cardiac SNA in severe CHF. 123I-MIBG scintigraphy is effective in assessing the cardiac functional status and SNA in patients with CHF in vivo. Moreover, changes in PP and HR indicate well alteration in SNA.

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Effect of Vasopressin on Cardiovascular and Renal Functions and ANP Release under Plasma Volume Expansion.

Cited by 3 publications

References 23 publications

Role of vagal nerves and atrial natriuretic hormone in vasopressin release and a diuresis under hypertonic volume expansion

Role of vagal nerves and atrial natriuretic hormone in vasopressin release and a diuresis under hypertonic volume expansion

Loop analysis of blood pressure/volume homeostasis

Clinical Relationship of Myocardial Sympathetic Nervous Activity to Cardiovascular Functions in Chronic Heart Failure: Assessment by Myocardial Scintigraphy with 123I-Metaiodobenzylguanidine

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