Effect of Vascular Senescence on the Efficacy and Safety of Warfarin: Insights from Rat Models and a Prospective Cohort Study

Abstract

Non-standard abbreviations: atrial fibrillation (AF), alanine transaminase (ALT), antithrombin III (AT3), advanced glycation end-products (AGEs), activated partial thromboplastin time (APTT), body mass index (BMI), carotid-femoral pulse wave velocity (cfPWV), coronary heart disease (CHD), computed tomography (CT), cytochrome P4502C9 (CYP2C9), D-dimer (DD2), d-galactose (D-Gal), deep vein thrombosis (DVT), fibrinogen degradation products (FDP), fibrinogen (FIB), hematoxylin and eosin (H&E), intracranial hemorrhage (ICH), international normalized ratio (INR), journal of the American College of Cardiology (JACC), low-density lipoprotein cholesterol (LDL-C), milk fat globule epidermal growth factor 8 (MFG-E8), matrix gla protein (MGP), phosphate-buffered saline (PBS), pulmonary embolism (PE), pulse pressure (PP), propensity score matching (PSM), single nucleotide polymorphism (SNPs), specific pathogen-free (SPF), thrombin time (TT), target therapeutic range (TTR), vitamin D3 and nicotine (VDN), vitamin K epoxide reductase complex subunit 1 (VKORC1).