Effect of vascular endothelial growth factor-C expression on lymph node metastasis in human cholangiocarcinoma

Zhao, Rui; Chang, Yuan; Liu, Zhao; Liu, Yanfeng; Guo, Shu; Yu, Ji; Wang, Jiayong

doi:10.3892/ol.2015.3309

Cited by 10 publications

(6 citation statements)

References 12 publications

(11 reference statements)

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“…Among them, VEGF-C is implicated in the formation of the initial lymphatic vessels (small), while it cooperates with Ang-1 and Ang-2 in the formation of the terminal lymphatic vessels. 114 , 115 Neoplastic cells secrete PDGF-D, which binds to PDGFRβ expressed on CAFs and induces ERK/NF-kB and JNK signalling. 111 This cascade of events promotes the secretion of VEGF-C by CAFs and the increase in the lymphatic vasculature along with tumour cell intravasation.…”

Section: Vegf and Tumour Microenvironment In Cholangiocarcinomamentioning

confidence: 99%

New insights on the role of vascular endothelial growth factor in biliary pathophysiology

et al. 2021

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Section: Vegf and Tumour Microenvironment In Cholangiocarcinomamentioning

confidence: 99%

New insights on the role of vascular endothelial growth factor in biliary pathophysiology

et al. 2021

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“…Malignant tumor poses a serious threat to human health [ 21 ]. Previous studies have proved that VEGF plays an essential role in the occurrence and development of tumors, but the current research results are inconsistent [ 16 , 19 , 22 ]. In this study, a meta-analysis was conducted on the relationship between VEGF and the prognosis of patients with intrahepatic cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

The VEGF expression associated with prognosis in patients with intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

Cai

Wang

et al. 2022

World J Surg Onc

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Objective To systematically evaluate the relationship between vascular endothelial growth factor (VEGF) and prognosis of intrahepatic cholangiocarcinoma by meta-analysis. Methods We systematically searched relevant studies in the databases of PubMed, Embase, Cochrane Library, CNKI, Wangfang, and Web of Science, with search dates limited to September 1, 2021. We extracted relevant data, including prognosis and clinicopathological features of patients with different expressions of VEGF in intrahepatic cholangiocarcinoma. The combined hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI) were calculated to evaluate the link strength between VEGF and prognosis of cholangiocarcinoma patients. Results A total of 7 eligible studies with 495 patients were included in this meta-analysis. The results showed that the high expression of VEGF was significantly related to poor overall survival (OS) (HR = 1.93, 95% CI 1.52–2.46, P < 0.05) in patients with intrahepatic cholangiocarcinoma. Moreover, high expression of VEGF in tumor tissues associated with lymph node metastasis (LNM) (OR = 6.79, 95% CI 3.93–11.73, P < 0.05) and advanced TNM stage (OR = 4.35, 95% CI 2.34–8.07, P < 0.05) in intrahepatic cholangiocarcinoma. Sensitivity analysis shows that the meta-analysis results are stable and reliable. Conclusion The expression of VEGF is related to the OS of patients with intrahepatic cholangiocarcinoma, and the OS of patients with high expression of VEGF is shorter. VEGF may be a novel predictor of intrahepatic cholangiocarcinoma patients. Trial registration PROSPERO (CRD42022297443).

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“…CCA is a fatal disease of bile duct epithelial cells, with dismal prognosis [20]. Due to the delay in early diagnosis, the major of CCA patients are diagnosed with metastatic disease, leading to limited therapeutic effects and poor outcomes [21]. Thus, identi cation of novel biomarkers for early diagnosis of CCA may be a promising way to improve the prognosis of CCA patients.…”

Section: Discussionmentioning

confidence: 99%

hTERT Represents an Innovative Bio-marker in Cholangiocarcinoma Detection

Wang¹,

Li²,

Zheng³

et al. 2020

Preprint

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Background: The study was aimed to examine the diagnostic value of serum human telomerase reverse transcriptiptase (hTERT) in patients with cholangiocarcinoma (CCA).Methods: Serum hTERT in CCA patients and healthy controls was detected by quantitative real-time PCR (qRT-PCR) and compared by student’s t-test. Relationships of serum hTERT and clinical parameters were explained by Chi-square test. The receiver operating characteristics (ROC) analysis was conducted to identify the diagnostic value of serum hTERT in CCA.Results: Serum hTERT was up-regulated in CCA patients compared with healthy controls (P<0.05). Furthermore, serum hTERT was closely related with differentiation (P=0.005), distant metastasis (P=0.015) and TNM stage (P=0.009). The AUC value of ROC curve was 0.901, demonstrating that serum hTERT could discriminate between CCA and healthy individuals, with the cutoff point of 1.88. Besides, the diagnostic specificity and sensitivity of serum hTERT in CCA were 89.7% and 76.0%, respectively.Conclusions: hTERT may be a promising biomarker for diagnosis of CCA.

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Effect of vascular endothelial growth factor-C expression on lymph node metastasis in human cholangiocarcinoma

Abstract: Abstract. The present study aimed to evaluate the expression of vascular endothelial growth factor C (VEGF-C) in human cholangiocarcinoma tissues and its role in metastasis in vitro.

Cited by 10 publications

References 12 publications

New insights on the role of vascular endothelial growth factor in biliary pathophysiology

New insights on the role of vascular endothelial growth factor in biliary pathophysiology

The VEGF expression associated with prognosis in patients with intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

hTERT Represents an Innovative Bio-marker in Cholangiocarcinoma Detection

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Effect of vascular endothelial growth factor-C expression on lymph node metastasis in human cholangiocarcinoma

Abstract: Abstract. The present study aimed to evaluate the expression of vascular endothelial growth factor C (VEGF-C) in human cholangiocarcinoma tissues and its role in metastasis in vitro.

Cited by 10 publications

References 12 publications

New insights on the role of vascular endothelial growth factor in biliary pathophysiology

New insights on the role of vascular endothelial growth factor in biliary pathophysiology

The VEGF expression associated with prognosis in patients with intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

hTERT&nbsp;Represents an Innovative Bio-marker in Cholangiocarcinoma Detection

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hTERT Represents an Innovative Bio-marker in Cholangiocarcinoma Detection