Effect of varying freezing and thawing rates in experimental cryosurgery

Gage, Andrew A.; Guest, Katrina; Montes, Mario; Caruana, Joseph; Whalen, Daniel A.

doi:10.1016/0011-2240(85)90172-5

Cited by 180 publications

(95 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However little attention has been given to the local effects of cryosurgery on the tumour blood supply. It has been shown that large blood vessels may act as a heat sink to freezing (Gage et al, 1985;McIntosh et al, 1985) while smaller vessels such as arterioles and venules are less resistant with evidence of damage and gap formation in the endothelium cryosurgery resulting in extravasation of intraluminal contents (Whittaker, 1984).…”

mentioning

confidence: 99%

Effect of cryosurgery on liver blood flow

Brown

Bayjoo²,

Reed³

1993

Br J Cancer

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Effect of cryosurgery on liver blood flow

Brown

Bayjoo²,

Reed³

1993

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…According to current knowledge, the use of at least two freeze-thaw cycles with fast freezing and slow thawing is particularly effective [11]. The freezing process should last at least 10 minutes since equilibrium between cold generation and the dissipation of cold at the periphery of the ablation zone is achieved and the ice ball reaches its maximum size only after 10 -15 minutes.…”

Section: Mechanism Of Action and Cryobiologymentioning

confidence: 99%

Current Technique and Application of Percutaneous Cryotherapy

Mahnken

König

Figiel

2018

Fortschr Röntgenstr

View full text Add to dashboard Cite

ABSTR AC TPurpose Local ablative therapies have become an established treatment option in interventional oncology. Radiofrequency ablation (RFA) and microwave ablation (MWA) are a standard of care in the treatment of hepatocellular carcinoma (HCC). Currently, there is an increasing interest in cryotherapy, one of the oldest ablation techniques. It has some unique characteristics with regard to technology and mechanism of action.Materials and Methods A systematic literature search using the terms cryotherapy, cryosurgery and cryoablation was performed. Selected studies are presented dealing with the mechanism of action, cryobiology and clinical use of percutaneous, image-guided cryoablation. Recent developments and perspectives are presented.Results Cryotherapy is increasingly used and has been included in guidelines for selected tumor entities such as renal cell carcinoma. Cryo-immunotherapy and combination treatments are future areas of interest.Conclusion Cryoabalation may be used in many indications.Its major advantages are its unique visualization and the anesthesiologic effects of cold. While there are only a few prospectively randomized trials, the existing data on the use of cryoablation is promising. Its use appears to be justified in selected tumors, oligometastatic patients and for palliative indications.

show abstract

“…First, recrystallization and coalescence of intraand extracellular ice crystals increase the osmotic damage and generate shear forces, which further disrupt tissue architecture. 13,16 Second, restoration of microcirculatory function is associated with a hyperemic vascular response characterized by hemorrhage and inflammation. [10][11][12] Specifically, blood vessel walls become porous, leading to increased capillary permeability, and subsequent interstitial edema.…”

Section: A Brief Backgroundmentioning

confidence: 99%