Effect of various surfactants and their concentration on controlled release of captopril from polymeric matrices

Nokhodchi, Ali; Hassanzadeh, Davoud; Monajjemzadeh, Farnaz; Taghizadeh, N

doi:10.2478/v10007-008-0004-5

Cited by 20 publications

(7 citation statements)

References 17 publications

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“…The dissolution efficiency (DE)[22] of various solid dispersions was calculated. DE is used as the criterion for comparing the effect of polymer concentration on the release rate.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Metformin Hydrochloride − Compritol 888 ATO Solid Dispersion

Jagdale¹,

Patil²,

Kuchekar³

et al. 2011

Journal of Young Pharmacists

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Metformin hydrochloride (MET) sustained-release solid dispersions (SD) were prepared by the solvent evaporation and closed melt method, using compritol 888 ATO as the polymer with five different drug-carrier ratios. Characterization of solid dispersion was carried out by Fourier Transform Infrared (FTIR) spectroscopy, ultraviolet (UV) spectroscopy, Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD). The FTIR and UV studies suggested that no bond formation had occurred between the polymer and the drug. DSC and XPRD results ruled out any interaction or complex formation between the drug and the polymer. The formulated SD had acceptable physicochemical characters and SD with a 1 : 4 drug : Polymer ratio, which released the drug over an extended period of eight-to-ten hours. The data obtained from the in vitro release studies were fitted with various kinetic models and were found to follow the Korsmeyer-Peppas equation. The prepared SD showed good stability over the studied time period. The solvent evaporation method was found to be more helpful than the closed melt method, giving the sustained release action. The SD with a 1 : 4 ratio of drug to polymer, by the solvent evaporation method, was selected as the most effective candidate for the subsequent development of a well-timed, sustained-release dosage form of the drug.

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“…The dissolution efficiency (DE)[22] of various solid dispersions was calculated. DE is used as the criterion for comparing the effect of polymer concentration on the release rate.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Metformin Hydrochloride − Compritol 888 ATO Solid Dispersion

Jagdale¹,

Patil²,

Kuchekar³

et al. 2011

Journal of Young Pharmacists

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show abstract

“…DE is defined as the area under the dissolution curve up to the time “t,” expressed as percentage of the area of rectangle described by 100% dissolution in the same time as in equation 1. [17]…”

Section: Methodsmentioning

confidence: 99%

Formulation Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride

Patil¹,

Kuchekar²,

Chabukswar³

et al. 2010

Journal of Young Pharmacists

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The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calorimetry and X-ray powder diffractometry. The optimized formulation was subjected to accelerated stability testing as per ICH guidelines. Release data were examined kinetically. SD with 1:4 and 1:5 ratio of drug to polymer obtained by solvent evaporation and cogrinding were selected as the best candidates suitable for prolonged-release oral dosage form of metformin.

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“…The selection of appropriate stress conditions for accelerating the drug release is dependent on the nature and composition of the formulation, stability of the drug and release medium, release mechanisms, and requirements related to the sampling interval and duration of the study [ 14 ]. In this work, different combinations of four conditions of release media including: (a) temperature [ 11 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]; (b) presence of organic solvents such as alcohol, acetone, acetonitrile as co-solvents [ 12 , 15 , 28 ]; (c) presence of surfactants [ 18 , 28 , 29 , 30 , 31 ], and (d) pH [ 12 , 15 , 16 ] were used to develop an accelerated in vitro drug release method for screening ISD systems for long-term release of LNG for contraception. The correlations between the release kinetics and mechanisms of LNG from ISD systems under real-time and accelerated conditions were established.…”

Section: Introductionmentioning

confidence: 99%

An Accelerated Release Study to Evaluate Long-Acting Contraceptive Levonorgestrel-Containing in Situ Forming Depot Systems

et al. 2016

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Biodegradable polymer-based injectable in situ forming depot (ISD) systems that solidify in the body to form a solid or semisolid reservoir are becoming increasingly attractive as an injectable dosage form for sustained (months to years) parenteral drug delivery. Evaluation of long-term drug release from the ISD systems during the formulation development is laborious and costly. An accelerated release method that can effectively correlate the months to years of long-term release in a short time such as days or weeks is economically needed. However, no such accelerated ISD system release method has been reported in the literature to date. The objective of the current study was to develop a short-term accelerated in vitro release method for contraceptive levonorgestrel (LNG)-containing ISD systems to screen formulations for more than 3-month contraception after a single subcutaneous injection. The LNG-containing ISD formulations were prepared by using biodegradable poly(lactide-co-glycolide) and polylactic acid polymer and solvent mixtures containing N-methyl-2-pyrrolidone and benzyl benzoate or triethyl citrate. Drug release studies were performed under real-time (long-term) conditions (PBS, pH 7.4, 37 °C) and four accelerated (short-term) conditions: (A) PBS, pH 7.4, 50 °C; (B) 25% ethanol in PBS, pH 7.4, 50 °C; (C) 25% ethanol in PBS, 2% Tween 20, pH 7.4, 50 °C; and (D) 25% ethanol in PBS, 2% Tween 20, pH 9, 50 °C. The LNG release profile, including the release mechanism under the accelerated condition D within two weeks, correlated (r2 ≥ 0.98) well with that under real-time conditions at four months.

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Effect of various surfactants and their concentration on controlled release of captopril from polymeric matrices

Cited by 20 publications

References 17 publications

Preparation and Characterization of Metformin Hydrochloride − Compritol 888 ATO Solid Dispersion

Preparation and Characterization of Metformin Hydrochloride − Compritol 888 ATO Solid Dispersion

Formulation Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride

An Accelerated Release Study to Evaluate Long-Acting Contraceptive Levonorgestrel-Containing in Situ Forming Depot Systems

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