Effect of various metabolic inhibitors on biphenyl metabolism in isolated rat hepatocytes

Wiebkin, Philip; Parker, Gerald L.; Fry, Jeffrey R.; Bridges, James W.

doi:10.1016/0006-2952(79)90127-8

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Cited by 29 publications

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“…It is noteworthy that DNPMEis a structural analogue of anisole, which can be metabolized by CYPs to phenol and two different hydroxyanisole derivativesby way of O-dealkylation and aromatic hydroxylation, respectively [37]. Moreover, DNP has been shown to be metabolized to aminonitrophenol and diaminophenol, which could augment the activity of some CYP isoforms [38]. Hence,further investigations will be needed to identify the full spectrum of DNPME metabolites and to determine whether DNPME could interact with the biotransformation of some marketed drugs.…”

Section: Discussionmentioning

confidence: 99%

Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease

Fromenty¹

2014

Clinics and Research in Hepatology and Gastroenterology

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Uncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty liver disease and type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%