Effect of various exercise protocols on neuropathic pain in individuals with type 2 diabetes with peripheral neuropathy: A systematic review and meta-analysis

Tatikola, Sripada Pallavi; Natarajan, Venkatesh; Desai, Venkata Krishnaveni; Asirvatham, Adlyne Reena; Rajsekhar, Hannah

doi:10.1016/j.dsx.2022.102603

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…If optimally implemented, these effects could further increase the potential of exercise to slow down the progression of T2DM and its complications (e.g., diabetic retinopathy or neuropathy) [ 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Acute and Chronic Exercise on Appetite and Appetite Regulation in Patients with Prediabetes or Type 2 Diabetes Mellitus—A Systematic Review

Konitz,

Schwensfeier,

Predel

et al. 2024

Nutrients

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This systematic review aims to analyze the effects of acute and chronic exercise on appetite and appetite regulation in patients with abnormal glycemic control. PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials were searched for eligible studies. The included studies had to report assessments of appetite (primary outcome). Levels of appetite-regulating hormones were analyzed as secondary outcomes (considered, if additionally reported). Seven studies with a total number of 211 patients with prediabetes or type 2 diabetes mellitus (T2DM) met the inclusion criteria. Ratings of hunger, satiety, fullness, prospective food consumption, nausea, and desire to eat, as well as levels of (des-)acylated ghrelin, glucagon-like peptide 1, glucose-dependent insulinotropic peptide, pancreatic polypeptide, peptide tyrosine tyrosine, leptin, and spexin were considered. Following acute exercise, the effects on appetite (measured up to one day post-exercise) varied, while there were either no changes or a decrease in appetite ratings following chronic exercise, both compared to control conditions (without exercise). These results were accompanied by inconsistent changes in appetite-regulating hormone levels. The overall risk of bias was low. The present results provide more evidence for an appetite-reducing rather than an appetite-increasing effect of (chronic) exercise on patients with prediabetes or T2DM. PROSPERO ID: CRD42023459322.

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Section: Discussionmentioning

confidence: 99%

The Influence of Acute and Chronic Exercise on Appetite and Appetite Regulation in Patients with Prediabetes or Type 2 Diabetes Mellitus—A Systematic Review

Konitz,

Schwensfeier,

Predel

et al. 2024

Nutrients

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“…Exercise has specific benefits in mitigating the progression and impact of DPN. Regular exercise can promote nerve regeneration, help maintain the integrity of nerve fibers, improve nerve function, and mitigate the progression of peripheral neuropathy [10,40,41]. For example, exercise counseling and dietary control in those with impaired glucose tolerance led to the recovery in small nerve fiber function [42].…”

Section: So How Is Exercise Thought To Help In the Development Of Dpn?mentioning

confidence: 99%

“…For example, exercise counseling and dietary control in those with impaired glucose tolerance led to the recovery in small nerve fiber function [42]. Additionally, despite the complex relationship between exercise and pain in DPN, several studies suggest that appropriate exercise regimens can help manage neuropathic pain [40][41][42][43]. This may be attributed to the release of endorphins, improved circulation, and enhanced neurotrophic support [40][41][42][43].…”

Section: So How Is Exercise Thought To Help In the Development Of Dpn?mentioning

confidence: 99%

“…Additionally, despite the complex relationship between exercise and pain in DPN, several studies suggest that appropriate exercise regimens can help manage neuropathic pain [40][41][42][43]. This may be attributed to the release of endorphins, improved circulation, and enhanced neurotrophic support [40][41][42][43]. Exercise-induced suppression of pro-inflammatory responses, a reversal in the deficit of NO synthesis/endothelial NO synthase (eNOS) expression, and modulation of voltage-gated calcium channels to affect opioidergic tone in nerves also likely contribute to overcoming peripheral nerve dysfunction and reducing pain [43].…”

Section: So How Is Exercise Thought To Help In the Development Of Dpn?mentioning

confidence: 99%

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Diabetes-induced peripheral neuropathy: Is prescribing physical exercise the answer?

Akhtar

2024

Biomol Biomed

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Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, has become a global health concern with an increasing prevalence worldwide. The International Diabetes Federation (IDF) estimates that over 537 million adults currently have diabetes, and they project that this figure will likely exceed 780 million by 2045. In addition, a further 541 million adults are thought to exhibit impaired glucose tolerance/prediabetes. Among its many complications, diabetic peripheral neuropathy (DPN) affects up to 50% of sufferers, with some studies showing that its prevalence, even in prediabetes, may be as high as 77%. Read more in the PDF.

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“…In general, studies will differentiate between aerobic and anaerobic exercises, and how each type of muscle contraction acts on pain. We suggest some review articles on this topic [40,41,[97][98][99][100]. [87,88].…”

Section: Current Guidelines For the Treatment Of Neuropathic Painmentioning

confidence: 99%

A Narrative Review of the Dorsal Root Ganglia and Spinal Cord Mechanisms of Action of Neuromodulation Therapies in Neuropathic Pain

da Silva,

Martelossi-Cebinelli,

Yaekashi

et al. 2024

Brain Sciences

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Neuropathic pain arises from injuries to the nervous system in diseases such as diabetes, infections, toxicity, and traumas. The underlying mechanism of neuropathic pain involves peripheral and central pathological modifications. Peripheral mechanisms entail nerve damage, leading to neuronal hypersensitivity and ectopic action potentials. Central sensitization involves a neuropathological process with increased responsiveness of the nociceptive neurons in the central nervous system (CNS) to their normal or subthreshold input due to persistent stimuli, leading to sustained electrical discharge, synaptic plasticity, and aberrant processing in the CNS. Current treatments, both pharmacological and non-pharmacological, aim to alleviate symptoms but often face challenges due to the complexity of neuropathic pain. Neuromodulation is emerging as an important therapeutic approach for the treatment of neuropathic pain in patients unresponsive to common therapies, by promoting the normalization of neuronal and/or glial activity and by targeting cerebral cortical regions, spinal cord, dorsal root ganglia, and nerve endings. Having a better understanding of the efficacy, adverse events and applicability of neuromodulation through pre-clinical studies is of great importance. Unveiling the mechanisms and characteristics of neuromodulation to manage neuropathic pain is essential to understand how to use it. In the present article, we review the current understanding supporting dorsal root ganglia and spinal cord neuromodulation as a therapeutic approach for neuropathic pain.

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Effect of various exercise protocols on neuropathic pain in individuals with type 2 diabetes with peripheral neuropathy: A systematic review and meta-analysis

Cited by 13 publications

References 24 publications

The Influence of Acute and Chronic Exercise on Appetite and Appetite Regulation in Patients with Prediabetes or Type 2 Diabetes Mellitus—A Systematic Review

The Influence of Acute and Chronic Exercise on Appetite and Appetite Regulation in Patients with Prediabetes or Type 2 Diabetes Mellitus—A Systematic Review

Diabetes-induced peripheral neuropathy: Is prescribing physical exercise the answer?

A Narrative Review of the Dorsal Root Ganglia and Spinal Cord Mechanisms of Action of Neuromodulation Therapies in Neuropathic Pain

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