Effect of various Danshen injections on patients with coronary heart disease after percutaneous coronary intervention

Abstract

Background:Patients with coronary heart disease (CHD) who undergo percutaneous coronary intervention (PCI) have a certain risk of vascular complications, including coronary restenosis and thrombosis. Many recent randomized controlled trials have reported that Danshen injection (DSI) combined with conventional Western medicine can significantly reduce the occurrence of major cardiovascular adverse events in patients with CHD after PCI. However, there are many types of DSIs, and no study has yet compared each type. Therefore, we propose a study protocol for the systematic evaluation of the efficacy of various DSIs in the treatment of CHD after PCI.Methods:We will search the following electronic databases for randomized controlled trials evaluating the effect of DSI in patients with CHD after PCI: PubMed, Embase, Web of Science, Cochrane Library, Scopus, Ovid Evidence-Based Medicine Reviews, China National Knowledge Infrastructure, and Chinese Biomedicine Literature Database. Each database will be searched from inception to April 2018. The entire process will include study selection, data extraction, risk of bias assessment, pairwise meta-analyses, and network meta-analyses.Results:This proposed study will compare the efficacy of different DSIs in the treatment of patients with CHD after PCI. The outcomes will include major cardiovascular adverse events and left ventricular ejection fraction.Conclusion:This proposed systematic review will evaluate the different advantages of various types of DSIs in the treatment of patients with CHD after PCI.Registration:PROSPERO (registration number: CRD42018092705).

Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications

“…Coronary atherosclerotic heart disease, also known as CHD, is the most common type of CVD and one of the deadly diseases among humans (Gao et al, 2017; Liu et al, 2018). The mortality rate of CHD is the highest among all CVDs, accounting for about 40% of all CVD-related deaths (Rezaei-Hachesu et al, 2017; Zhu et al, 2018). Numerous studies have shown that diabetes, hypertension, dyslipidemias, abdominal obesity, unhealthy diet, smoking, and psychosocial stress are major risk factors for CHD (Chow et al, 2007; Gupta et al, 2016; Ajith and Jayakumar, 2018).…”

Functional Evaluation of Percutaneous Coronary Intervention Based on CT Images of Three-Dimensional Reconstructed Coronary Artery Model

“…However, 25.3% of patients with coronary heart disease still have major adverse cardiovascular and cerebrovascular events within 1 year after PCI, such as myocardial infarction, stroke, and sudden death. With the deepening of coronary artery complexity, the incidence of major adverse cardiovascular and cerebrovascular events is also increasing [8,18,19]. Terefore, the analysis of relevant factors refecting the complexity of coronary artery is helpful to formulate reasonable intervention measures, which has very important clinical guiding signifcance.…”

Predictive value of miRNA-21 on coronary restenosis after percutaneous coronary intervention in patients with coronary heart disease

“…[ 26 , 27 ] This kind of damage causes the body to repair, while excessive repair may result in vascular restenosis. [ 28 ] PCI treatment may do direct harm to the arterial wall, which may give rise to inflammatory reaction, thrombosis and intimal hyperplasia. [ 29 , 30 ] These changes in vascular wall eventually bring neointimal formation and vascular remodeling, thus leading to restenosis after PCI.…”