Effect of Vancomycin, Gentamicin and Clindamycin on Cartilage Cells In Vitro
Hermann O. Mayr,
Nina Regenbrecht,
Moritz Florian Mayr
et al.
Abstract:Background: The treatment of grafts with vancomycin for ligament reconstruction in knee surgery is the current standard. However, high antibiotic concentrations have chondrotoxic effects. Purpose: To test the chondrotoxicity of clindamycin, gentamicin and vancomycin in comparable concentrations. In vitro and in vivo effective concentrations hugely vary from drug to drug. To allow for comparisons between these three commonly used antibiotics, the concentration ranges frequently used in orthopedic surgical setti… Show more
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