Effect of vaginal progesterone in tocolytic therapy during preterm labor in twin pregnancies: Secondary analysis of a placebo‐controlled randomized trial

Abstract

Prophylactic use of 200 mg of vaginal progesterone does not influence the latency to delivery in women with twin pregnancies treated with tocolysis because of preterm labor.

Timing of Delivery for Twins With Growth Discordance and Growth Restriction

“…1) (Soliman et al Am J Obstet Gynecol 2015;212:S261-2.). [6][7][8][9][10][11][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] Of the 17 studies on dichorionic twins, 15 provided data on stillbirth and neonatal mortality and two provided data on neonatal mortality only. For monochorionic twins, 12 studies provided data on stillbirth and neonatal mortality and one provided data on neonatal mortality only.…”

Prophylactic cervical cerclage, fully embedded, for twin pregnancies following fertility treatment

“…Vaginal progesterone has been shown to be beneficial in high-risk singleton pregnancies [10], however, in twin pregnancies, vaginal progesterone administration does not prevent preterm delivery [11,12].…”

Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry: Conception of Prostaglandin F2α Receptor Allosteric Modulators That Delay Preterm Birth

“…Healthcare costs connected to preterm birth are significant: >$26.2 billion in 2005 in the USA alone amounting to $51,600 per premature birth . Tocolytic drugs currently used in the clinical setting to block uterine contractions have marginal efficacy and at times are associated with significant adverse effects to either the mother and/or fetus . Although they may extend gestation to 48 h needed to administer corticosteroids to the parturient for fetal surfactant maturation, for many patients, gestation needs to be prolonged for longer periods.…”