Effect of vaginal pH on efficacy of the dinoprostone gel for cervical ripening/labor induction

Ramsey, Patrick S.; Ogburn, Paul L.; Harris, Denise Y.; Heise, Robert H.; Ramin, Kirk D.

doi:10.1067/mob.2002.126987

Cited by 18 publications

(14 citation statements)

References 10 publications

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“…Vaginal pH appears to play an important role in the efficacy of vaginally administered drugs. 27) Viscosity measurements in vaginal formulation can offer important information about formulation extrudability from packaging, and about squeezing, and spreading properties. The formulation C2 had the highest viscosity among all the gels tested.…”

Section: )mentioning

confidence: 99%

Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels

Tuğcu-Demiröz

2017

Chem. Pharm. Bull.

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Liposomal vaginal drug delivery systems are important strategy in the treatment of both topical and systemic diseases. The aim of this study was to develop a vaginal delivery system for benzydamine hydrochloride (BNZ) loaded liposomes dispersed into mucoadhesive gels. The delivery system was also designed for a once a day dosage and to obtain controlled release of the BNZ. For this purpose BNZ containing gel formulations using hydroxypropyl methylcellulose (

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Section: )mentioning

confidence: 99%

Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels

Tuğcu-Demiröz

2017

Chem. Pharm. Bull.

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“…In recent studies, vaginal pH has been introduced as an effective factor on prostaglandins function in cervical ripening, by an effect on drug ionization, absorption, and ultimately the clinical response of the drug, 7,8 but contradictory results have also been reported in some studies 9,10 . Some studies have reported higher efficacy of Misoprostol in an acidic environment and some in an alkaline environment 10‐13,18 .…”

Section: Discussionmentioning

confidence: 99%

Effect of vaginal washing before Misoprostol insertion on cervical ripening before induction of labor: A randomized single‐blind clinical trial

Kabodmehri

Sharami

Milani

et al. 2022

Health Science Reports

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Background Vaginal pH is acidic in pregnancy, but there is no information about pH changes in pregnancy, and contradictory results have been reported from the effectiveness of Misoprostol at different vaginal pH. This study aimed to evaluate the effect of vaginal washing before Misoprostol insertion on cervical ripening before induction of labor in comparison with the control group. Methods This randomized single‐blind clinical trial was performed on 148 pregnant women who were candidates for induction of labor. Subjects were randomly divided into two groups of intervention (vaginal washing with 20 cc of normal saline 0.9% before Misoprostol insertion) and the control group (without vaginal washing). Vaginal pH and Bishop scores were measured before and after the intervention. The two groups were compared in demographic‐obstetric variables, the success rate of induction of labor, maternal and neonatal outcomes, and Misoprostol dose. Results After the intervention, there was no statistically significant difference between the pH before and after in the group with vaginal washing. There was no significant difference between the two groups in the type and duration of labor, and maternal and neonatal outcomes (P > .05). The frequency of normal delivery less than 12 hours in the intervention group was higher than in the control group. Although this difference was not statistically significant due to the small number of subjects, it is clinically significant. Conclusion The results of the present study showed that vaginal washing with normal saline before Misoprostol insertion for induction of labor did not affect the success of induction and duration of labor.

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“…[9] who used PGE 2 intracervical gel compared with intracervical insertion of Foley catheter; however this gel is not readily available in our hospital. It is well known that some factors might affect the safety, absorption and efficacy of PGE 2 , such as the vehicle, oily lubrication, humidity and possibly vaginal pH [20,21]. The difference in results may be attributed to the type of PGE 2 used, as the main effect of PGE 2 gel is cervical ripening and its contractile effect is considered to be small [22,23].…”

Section: Discussionmentioning

confidence: 99%

Comparison of prostaglandin E2 tablets or Foley catheter for labour induction in grand multiparas

2004

East Mediterr Health J.

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The efficacy, safety and outcome of prostagl and in [PG] E2 was compared with Foley catheter for labour induction in gr and multiparous women. At a hospital in Jordan, 147 women with Bishop score </= 5 were r and omized to receive 3 mg PGE2 vaginal tablets [n = 75] or 50 mL intracervical Foley catheter [n = 72]. The change in Bishop score was significantly higher in the PGE2 group than the catheter group, and time from induction to delivery was significantly shorter in the PGE2 group. Significantly more women needed oxytocin for labour augmentation in the catheter than the PGE2 group and fetal distress was significantly more frequent. For gr and multiparas, PGE2 vaginal tablets may be preferable for ripening the cervix as well as for labour induction

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Effect of vaginal pH on efficacy of the dinoprostone gel for cervical ripening/labor induction

Cited by 18 publications

References 10 publications

Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels

Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels

Effect of vaginal washing before Misoprostol insertion on cervical ripening before induction of labor: A randomized single‐blind clinical trial

Comparison of prostaglandin E2 tablets or Foley catheter for labour induction in grand multiparas

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