Effect of vaccination on the course of novel coronavirus infection in young patients

Abstract

The features of the course of the new coronavirus infection in vaccinated and unvaccinated young patients (aged 18–35 years) were assessed. In total, 111 patients with new coronavirus infection were examined, and they were divided into two groups. The first group included 32 people vaccinated against the new coronavirus infection (21 men and 11 women; average age, 22. 31 ± 5. 04 years), and the second group included 79 unvaccinated people (70 men and 9 women; average age, 20. 76 ± 3. 674 years). A direct dependence of hospitalization time on the presence of vaccination was observed. The average volume of erythrocytes was significantly greater in the vaccinated group than in the unvaccinated group, and the average concentration of hemoglobin in erythrocytes was higher in the unvaccinated group, both at disease onset and over time. In addition, in the vaccinated group, the values of inflammatory markers in the blood such as erythrocyte sedimentation rate, C-reactive protein, ferritin, procalcitonin, and D-dimer, increase much faster. According to the results of repeated computed tomography, the unvaccinated group had longer persistence of signs of viral pneumonia. The primary pathology recorded on the electrocardiogram, particularly bradycardia, was more frequently recorded in the unvaccinated group. Overall, most patients, regardless of vaccination, had a mild course of new coronavirus infection. This may indicate a negative dependence of the severity of the new coronavirus infection on the age of the patient. Despite the low risk of developing complications of coronavirus infection at a young age, to prevent and quickly recover from a new coronavirus infection, all age groups are encouraged to receive vaccination, which will reduce the number of hospitalizations, burden on healthcare, and economic costs of medical care.