Effect of UV light on DNA replication and chain elongation in Chinese hamster UV61 cells

Different types of DNA damage play different roles in the etiology of sunlight‐induced melanoma

“…Immediately after UV exposure, DNA replication is inhibited in a dose‐dependent manner and recovers as a consequence of NER (reviewed by (Cleaver and Mitchell, 2010). The potency of the (6‐4)PD as a structural block to replication and transcription, its ability to signal cell cycle arrest (Lo et al., 2005) and the correlation between the recovery of replication and (6‐4)PD excision kinetics (Griffiths et al., 1990), suggests that the inhibition of DNA synthesis and activation of signal cascades associated with replication arrest is a major consequence of the (6‐4)PD. Given the fact that stalled replication forks are the predominant DNA damage response signals, it stands to reason that the (6‐4)PD may be responsible for significant changes in gene expression within the first few hours post‐irradiation.…”