Effect of UV dose on degradation of venlafaxine using UV/H<sub>2</sub>O<sub>2</sub>: perspective of augmenting UV units in wastewater treatment

Hollman, Jordan; Dominic, John Albino; Achari, Gopal; Langford, Cooper H.; Tay, Joo‐Hwa

doi:10.1080/09593330.2018.1521475

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…While the final objective of oxidation treatments is the compete mineralization of organic contaminants, this may not be the result. Particularly for ozone treatment, lab-scale literature provides an indication that much of the total mass of PhACs measured continues to exist in some altered form, as indicated by low reductions in total organic carbon after treatment (Hollman et al 2018;Mehrabani-Zeinabad et al 2015;Rosal et al 2008;Somathilake et al 2018). Analytical methods for quantification of PhACs identify a reduction in a specific compound, but they are not capable of determining if by-products have been produced, even if the only change to the original compound is a simple functional group substitution.…”

Section: Removal Of Phacs By Ozonationmentioning

confidence: 99%

“…While considerable data on the effectiveness of various treatment processes, especially advanced oxidation processes(AOPs), for the removal of PhACs can be found in the literature, almost all studies were conducted at lab or bench scale and very few reports exist that consider scaling of processes to address full-scale process effectiveness (Almomani et al 2016;Figueredo et al 2019;Hollman et al 2018;Mojiri et al 2019;Somathilake et al 2018). The complex matrix of treated municipal wastewater combined with very low PhAC concentrations and scaling issues make lab-scale data of low interest to designers and engineers who make decisions on process design in new municipal facilities.…”

Section: Introductionmentioning

confidence: 99%

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Pilot-Scale Treatment of Neutral Pharmaceuticals in Municipal Wastewater Using Reverse Osmosis and Ozonation

et al. 2020

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Pharmaceutically active compounds (PhACs) reaching surface waters through municipal wastewater are a concern, as existing treatment processes poorly remove them. While significant lab-scale evaluations have been performed on treatment options, full-scale tests are lacking. Presented is an experimental study from a full-scale research facility that is imbedded in a functioning municipal wastewater plant. Reverse osmosis and ozonation were tested as part of an active treatment train using secondary treated effluent from the adjoining facility. Reverse osmosis removed 92.6%, 99.0%, 99.6%, 97.8%, 99.0%, 99.6%, 99.9%, and 99.2% of metformin, cotinine, trimethoprim, caffeine, venlafaxine, carbamazepine, erythromycin, and fluoxetine, respectively. By ozone, sulfamethoxazole, carbamazepine, erythromycin and o-desmethylvenlafaxine were removed by more than 99.9%. Trimethoprim and venlafaxine were removed by more than 95%, with the remaining compounds removed by between 16% and 85%. Results demonstrate the effectiveness of reverse osmosis and ozonation for full-scale treatment.

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Section: Removal Of Phacs By Ozonationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pilot-Scale Treatment of Neutral Pharmaceuticals in Municipal Wastewater Using Reverse Osmosis and Ozonation

et al. 2020

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“…H 2 O 2 is widely used for industrial and medical purposes such as the cleaning of semiconductor surfaces, bleaching of pulp, treatment of wastewater, and disinfection . H 2 O 2 is typically produced by the autoxidation of anthracene derivatives .…”

Section: Introductionmentioning

confidence: 99%

Formation of Hydrogen Peroxide from O^–(H₂O)_n Clusters

Tachikawa

2021

J. Phys. Chem. A

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Hydrogen peroxide (H2O2) has recently received much attention as a safe and clean energy carrier for hydrogen molecules. In this study, based on direct ab initio molecular dynamics (AIMD) calculations, we demonstrated that H2O2 is directly formed via the photoelectron detachment of O–(H2O) n (n = 1–6) (water clusters of an oxygen radical anion). Three electronic states of oxygen atoms were examined in the calculations: O(X)(H2O) n (X = 3P, 1D, and 1S states). After the photoelectron detachment of O–(H2O) n (n = 1) to the 1S state, a complex comprising O(1S) and H2O, O(1 S)-OH2, was formed. A hydrogen atom of H2O immediately transferred to O(1S) during an intracluster reaction to form H2O2 as the final product. Simulations were run to obtain a total of 33 trajectories for n = 1 that all led to the formation of H2O2. The average reaction time of H2O2 formation was calculated to be 57.7 fs in the case of n = 1, indicating that the reaction was completed within 100 fs of electron detachment. All the reaction systems O(1S)(H2O) n (n = 1–6) indicated the formation of H2O2 by the same mechanism. The reaction times for n = 2–6 were calculated to range between 80 and 180 fs, indicating that the reaction for n = 1 is faster than that of the larger clusters, that is, the larger the cluster size, the slower the reaction is. The reaction dynamics of the triplet O(3P) and singlet O(1D) potential energy surfaces were calculated for comparison. All calculations yielded the dissociation product O(X)(H2O) n → O(X) + (H2O) n (X = 3P and 1D), indicating that the O(1S) state contributes to the formation of H2O2. The reaction mechanism was discussed based on the theoretical results.

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“…This in-turn reflects the poor state of affairs of improper effluent treatment practices prevalent in many countries. VEN and its metabolites were not part of the above-described studies, and, therefore, we have selected them, considering the high probabilities of occurrence of these ecotoxic molecules in effluent water and their potential harmful environmental impacts [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

“…The salient features of this method include minimum processing steps, the absence of secondary extraction steps or use carcinogenic solvents, and its robustness against excipients usually present in the aquatic environmental samples. The developed method was validated by using the International Conference on Harmonization (ICH) Q2 guidelines [ 36 ], and potential applicability to detect and quantify VEN and VEN metabolites in pharmaceutical formulations was also tested, to expand the scope of method for future application to body samples.…”

Section: Introductionmentioning

confidence: 99%

Rapid, Precise and Affordable Estimation of Venlafaxine and Its Metabolites in Highly Polluted Effluent Waters: Proof-of-Concept for Methodology

Hussain

Ramnarayanan²,

Roopashree³

et al. 2020

Molecules

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Widespread presence of pharmaceuticals and their metabolites in the environment of industrialized countries is an emerging global concern. Potential contamination of the soil and water by such pharmacologically active substances poses serious ecotoxicological implications. Several studies assessing the long-term ecological risks of pharmaceutical contaminants mainly focus on the risk assessment of the parent drug, while the potential contributions of their metabolites is often neglected. Presence of selective serotonin and norepinephrine reuptake inhibitor venlafaxine, an antidepressant drug, and its metabolites is a matter of serious concern for aquatic systems, since they are difficult to remove by traditional wastewater treatment processes. The concentration of VEN present in water is reportedly one of the highest among pharmaceuticals; however, the long-term effects of its metabolites have not yet been systematically studied. Given the consideration to complex and time-consuming effluent treatment, and realizing the importance of levels of venlafaxine and its metabolites, a simple and accurate analytical method for quick determination is needed. We designed a selective colorimetric method by using oxidative coupling of drug molecules with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) reagent, to quantify the presence of venlafaxine and its metabolites in aquatic samples, with special emphasis on effluent. The method was validated for selectivity, specificity and robustness as per the ICH Q2 guidelines to assess its suitability in pharmaceutical samples, as well. Highly sensitive and green economical analytical method was successfully established for estimation of venlafaxine and its metabolites in aquatic samples. The method was quick, as it involved minimum processing steps. The method was accurate and linear in the range of 0.5 to 80 ppm and could successfully detect lowest concentration of 1.3 ppm, thus qualifying its applicability for the desired purpose to check the presence of trace levels of VEN or its metabolites in aquatic samples or in pharmaceutical formulations.

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Effect of UV dose on degradation of venlafaxine using UV/H₂O₂: perspective of augmenting UV units in wastewater treatment

Cited by 14 publications

References 31 publications

Pilot-Scale Treatment of Neutral Pharmaceuticals in Municipal Wastewater Using Reverse Osmosis and Ozonation

Pilot-Scale Treatment of Neutral Pharmaceuticals in Municipal Wastewater Using Reverse Osmosis and Ozonation

Formation of Hydrogen Peroxide from O^–(H₂O)_n Clusters

Rapid, Precise and Affordable Estimation of Venlafaxine and Its Metabolites in Highly Polluted Effluent Waters: Proof-of-Concept for Methodology

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Effect of UV dose on degradation of venlafaxine using UV/H2O2: perspective of augmenting UV units in wastewater treatment

Cited by 14 publications

References 31 publications

Pilot-Scale Treatment of Neutral Pharmaceuticals in Municipal Wastewater Using Reverse Osmosis and Ozonation

Pilot-Scale Treatment of Neutral Pharmaceuticals in Municipal Wastewater Using Reverse Osmosis and Ozonation

Formation of Hydrogen Peroxide from O–(H2O)n Clusters

Rapid, Precise and Affordable Estimation of Venlafaxine and Its Metabolites in Highly Polluted Effluent Waters: Proof-of-Concept for Methodology

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Effect of UV dose on degradation of venlafaxine using UV/H₂O₂: perspective of augmenting UV units in wastewater treatment

Formation of Hydrogen Peroxide from O^–(H₂O)_n Clusters