Effect of uterine contractions on the human uteroplacental blood circulation

Borell, Ulf; Fernström, Ingmar; Ohlson, Lars; Wiqvist, N.

doi:10.1016/0002-9378(64)90057-2

Cited by 63 publications

(7 citation statements)

References 7 publications

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“…It has been shown that uterine contractions have an effect on uteroplacental blood flow which in turn may cause changes in cardiac preload and afterload 2,3 . The effect of uterine contractions on the maternal cardiovascular system provides some indication of contraction intensity and therefore may be of value in the differentiation of prelabor and false labor from active labor 2,4 …”

Section: Introductionmentioning

confidence: 99%

Non‐invasive cutaneous cardiovascular dynamics (CVD) as a predictor of preterm delivery: A pilot study

Ogunyemi

Vargas

Fukushima

et al. 2003

J of Obstet and Gynaecol

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Section: Introductionmentioning

confidence: 99%

Non‐invasive cutaneous cardiovascular dynamics (CVD) as a predictor of preterm delivery: A pilot study

Ogunyemi

Vargas

Fukushima

et al. 2003

J of Obstet and Gynaecol

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“…1982). During labour uterine contractions further influence the maternal placental blood flow (Borell et al 1964(Borell et al & 1965Greiss 1965). Accordingly, drugs with combined vasodilator and myometrial relaxant effects may be of clinical interest in pregnancies complicated by hypertension and increased uterine vascular resistance.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Nitrendipine on Myometrial and Vascular Smooth Muscle in Human Pregnant Uterus and Placenta

Maigaard

Forman

Brogaard‐Hansen

et al. 1986

Acta Pharmacologica et Toxicologica

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Human myometrial visceral and vascular preparations and placental chorionic and stem villous vessels were dissected from myometrial and placental specimens obtained at term Caesarean section and after vaginal delivery. Vascular ring preparations and myometrial strips were mounted in organ bath and isometric tension recorded. Only myometrial preparations developed spontaneous contractile activity, which was effectively blocked by the calcium channel blocker nitrendipine (NTD) 10−7M. Pretreatment with calcium‐depleted medium for 30 min. almost abolished myometrial responses to high K+ (124 mmol), oxytocin (OX) and prostaglandin F2a (PGF2a). Vascular responses to high K+ (124 mmol) were also nearly abolished by such treatment. However, noradrenaline (NA), vasopressin (VP) and PGF2a in myometrial arteries and PGF2a in chorionic vessels and stem villous arteries induced significant, but reduced contractions after calcium depletion. In all vascular preparations, exposed to calcium‐depleted medium, NTD (10−8M) almost abolished contractions induced by calcium (0.1–4.0 mM) in the presence of K+ (124 mmol) and depressed responses to calcium in the presence of the other agonists tested. NTD (10−10–10−7M) depressed myometrial contractions induced by K+, OX and PGF2a more effective than vascular responses to K+, NA, VP and PGF2a in the myometrial arteries and K+ and PGF2a in the placental arteries. It is concluded that activation of contraction in vessels from the human utero‐placental unit implies multiple cellular sources of calcium, while in myometrial smooth muscle, influx of superficially bound calcium may be an important initial step in contractile activation. Treatment with calcium channel blockers during late human pregnancy might involve relaxation of the myometrium together with vasodilatation of the myometrial and foetal placental vascular beds.

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“…In f'act, he was able to establish an inverse linear relationship between uterine blood flow and intraamniotic fluid pressture. Also, angiographic studies in pregnanit womein ani( monkeys have shown that blood flow to the placenta is markedly suppressed during uterine contraction (33,34). Blood flow to the placenta is not constant as in organs with capillary beds but occulrs in spurts throUgh the spiral arteries, and these spturts decrease or (lisappear dcuring contraction of the pregnant uiteruis.…”

Section: Discussionmentioning

confidence: 99%

Indomethacin is a Placental Vasodilator in the Dog

Gerber¹,

Branch²,

Hubbard³

et al. 1978

J. Clin. Invest.

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A B S T R A C T The effect of 8 mg/kg of indomethacin on uterine blood flow, prostaglandin prodtuction, and intraamniotic fluid pressuire was examined in late pregnant dogs. Uterine blood flow was measured with 15 gm radiolabeled microspheres. Becauise we f0)und that a significant percentage of the microspheres shunted through the placental circulation into the lungs, we calcuilated placental blood flow by adding the shunted microspheres through the placenta to the nonshunited microspheres in the placenta. Total uterine blood flow significantly increased from 271±69 ml/min during control period to 371±72 ml/min (P < 0.01) 30 min af ter indomethacin. This increase was attributable to the change in blood flow to the placental circulation (222 ±58 to 325±63 ml/min; P < 0.01). Associated with these hemodynamic changes we f0und an almost complete suppression of uterine prostaglandin E2 prodtuction (1,654±305 to 51±25 pg/ml; P < 0.01) as meastired by gas chromatography-mass spectrometry. In addition, we found that indomethacin treatment restulted in uterine relaxation as measured by intraamniotic fluiid pressure changes (11.2± 1.3 mm Hg to 8.5 +1.2 mm Hg; P < 0.001).We conclude that indomethacin causes an inerease in placental blood flow without any change in flow to the rest of the uterus, and that this dose of' the drug inhibits greater than 95% of uterine prostaglandin production. In addition, indomethacini is responsible for uterine relaxation. The increase in placental blood flow after indomethacin is probably a result of uterine relaxation, which is secondary to prostaglandin synthesis inhibition.

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Effect of uterine contractions on the human uteroplacental blood circulation

Cited by 63 publications

References 7 publications

Non‐invasive cutaneous cardiovascular dynamics (CVD) as a predictor of preterm delivery: A pilot study

Non‐invasive cutaneous cardiovascular dynamics (CVD) as a predictor of preterm delivery: A pilot study

Inhibitory Effects of Nitrendipine on Myometrial and Vascular Smooth Muscle in Human Pregnant Uterus and Placenta

Indomethacin is a Placental Vasodilator in the Dog

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