Effect of Using Different Strontium Salts on Dental Caries in the Rat

Curzon, M.E.J.; Spector, Phil

doi:10.1159/000260529

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…Similar results effects were obtained reported on rats exposed to Sr posteruptively by Olson et al [1978]. Curzon and Spector [1981] studied the effects of different Sr salts at [Sr] = 50 ppm on rat caries reduction and concluded that SrF2 was most effective, mainly because of its [F] = 22 ppm. Other salts varied in their effectiveness based on their bioavailability.…”

supporting

confidence: 85%

“…Animal studies on the effects Sr in preventing caries have been equivocal as no effects [Johnson and Hein, 1953;Olson et al, 1978], an increase [Hunt andNavia, 1972, 1975;Joseph et al, 1977] or a decrease [Losee and Adkins, 1968;Gedalia et al, 1975;Meyerowitz et al, 1979;Ashrafi et al, 1980;Curzon and Spector, 1981;Curzon, 1988] in caries incidence were have been reported. Generalization of overall Sr effects, however, is unjustified as differences depending on the dose and time of administration (pre-and/or post-eruptively) or the combined administration of Sr and F need to be analyzed for separately.…”

Section: Animal Caries Studiesmentioning

confidence: 99%

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Strontium and Caries: A Long and Complicated Relationship

Lippert

Hara²

2012

Caries Res

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Investigations into the role of strontium (Sr) in caries prevention have attracted great interest in the research community in the past, with its peak in the 1970-and 80ies. To this date, no clear indication of the relative importance of Sr in caries prevention has been provided. A vast number of animal caries, epidemiological and mechanistic studies have been conducted. Albeit Although a great level ofthere is much discrepancyexists in the literature, the majority of studies suggest that Sr exhibits some cariostatic properties and, predominantly in the presence of fluoride (F). An optimum Sr concentration of 5 to 10 ppm in drinking water has been proposed as a direct result of several epidemiological caries studies. Despite these results, no direct link can be established between Sr and caries prevention as, to date, no relevant, randomized control trials have been reported. The extrapolation of potential cariostatic properties of Sr from epidemiological studies is difficult due to the co-presence of several other trace elements in the water of the study areas, with many of these elements being attributed cariostatic properties in their own right.

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supporting

confidence: 85%

Section: Animal Caries Studiesmentioning

confidence: 99%

Strontium and Caries: A Long and Complicated Relationship

Lippert

Hara²

2012

Caries Res

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“…It has been suggested that the reduction in caries attributed to Sr (Curzon and Spector, 1981) may be a combined Sr and fluoride effect, resulting in improved crystallinity of carbonated apatite (Featherstone et al, 1983). Crystalline effects cannot be detected by the present test procedure.…”

Section: Resultsmentioning

confidence: 72%

Effect of Some Salts of Calcium, Sodium, Potassium, and Strontium on Intra-oral Enamel Demineralization

Brudevold¹,

Tehrani²,

Attarzadeh³

et al. 1985

J Dent Res

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A newly-developed intra-oral enamel demineralization test was used to evaluate the effect of supplementation of a 10% sucrose solution with various components on enamel demineralization induced by the sucrose. Five human subjects wore a palatal prosthesis holding eight blocks of subsurface bovine enamel covered with a layer of S. mutans cells. The test involved rinsing with sucrose solution or with sucrose solution supplemented with 0.162 mol/l of different calcium salts or equivalent concentrations of Na-, K-, and Sr salts; rinsing was for one min at times zero and 45 min of the 90-minute test period. Ca-propionate, Ca-acetate, and Ca-levulinate completely inhibited sucrose-induced enamel demineralization; Ca-chloride, Ca-lactate, and Ca-ascorbate gave from 65-75%, and K-acetate, Na-lactate, and Sr-lactate 39, 25, and 18% inhibition, respectively. Consideration of the anion dissociation constants and the Ca-anion association constants of the salts suggests that the observed inhibition is caused mainly by common ion effects and, to a lesser extent, by buffer effects.

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“…Although the effect of F is not dependent on the presence of Sr, and neither does the effect of Sr appear to depend on F, a combination of Sr and F in plaque may have an advantage over either ion alone. The two ions have a synergistic effect in reducing the dissolution of hydroxyapatite when present in acid solutions (Dedhiya et al, 1974), and have been reported to provide greater protection in in vitro caries models (Herbison and Handelman, 1975;Luoma et al, 1986) and in rat studies (Meyerowitz et al, 1979;Curzon and Spector, 1981;Luoma et al, 1984) when present together than when tested separately. Both ions are taken up by carious enamel, the combination producing a superior remineralizing effect (Little and Baer, 1979;Featherstone et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

The Concomitant Deposition of Strontium and Fluoride in Dental Plaque

Pearce

Sissons

1987

J Dent Res

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We have investigated the feasibility of incorporating Sr into dental plaque by means of an enzyme-dependent system known to increase Ca, P, and F levels in plaque. A solution containing Ca (20 mmol/L), P (12 mmol/L), MFP (4.7 mmol/L), F (0.3 mmol/L), and urea (500 mmol/L) was modified by equimolar replacement of Ca with 1, 2, 5, and 10 mmol/L Sr. Thin films of human salivary sediment incubated in these solutions showed increasing levels of acid-extractable Sr as the solution Sr increased. When the concentration exceeded 2 mmol/L, deposition of Ca, P, and F was reduced. In artificial plaque, grown on bovine enamel, from mixed human salivary organisms and treated with the solution containing 2 mmol Sr/L, there was a slightly smaller uptake of Ca, P, and Sr, but a greater uptake of F than in sediment treated with the same solution. Natural human plaque treated 12 times in vivo over three days with this solution (in the form of a mouthrinse) also showed substantial increases (from five- to 26-fold) in the concentrations of all four ions. Absolute levels of Ca, P, F, and especially Sr were, however, lower than those in the artificial plaque samples. (Ca + Sr)/P ratios suggested apatite deposition, and the correlation between amounts of Ca and Sr deposited in natural plaque samples suggested that Sr, like F, is structurally incorporated into this apatite. Fluctuations in the pH of natural plaque may promote apatite crystal maturation, causing a slow loss of Sr.(ABSTRACT TRUNCATED AT 250 WORDS)

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Effect of Using Different Strontium Salts on Dental Caries in the Rat

Cited by 10 publications

References 4 publications

Strontium and Caries: A Long and Complicated Relationship

Strontium and Caries: A Long and Complicated Relationship

Effect of Some Salts of Calcium, Sodium, Potassium, and Strontium on Intra-oral Enamel Demineralization

The Concomitant Deposition of Strontium and Fluoride in Dental Plaque

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