Effect of ursolic acid treatment on apoptosis and DNA damage in isoproterenol-induced myocardial infarction

Protective Effect of Hydroxytyrosol Against Cardiac Remodeling After Isoproterenol-Induced Myocardial Infarction in Rat

“…Serum cardiac troponins and cytosolic enzyme activities such as CK-MB, LDH and AST are very sensitive and specific diagnostic markers of acute myocardial infarction [19,20]. Our results confirmed previous studies reporting that isoproterenol induced significant increases in serum troponin-T level and CK-MB, LDH and AST activities which reflected the severe damage in myocardium tissues [20,21]. HT pre-and co-treatment reduced the activity of the marker enzymes in serum of isoproterenol-induced rats.…”

Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway

“…2). Moreover, ␣-SMA expression in the liver tissues is an indicator of hepatic stellate cell activation, which is recognized as being critical in liver fibrogenesis [14,21]. In this study, the ␣-SMA expression level markedly increased in mice treated with CCl 4 as compared with vehicle controls However, UA significantly decreased ␣-SMA expression levels in liver of CCl 4 -treated mice (P < 0.01) (Fig.…”

“…Ursolic acid (UA: 3␤-hydroxyurs-12-en-28-oic acid), a natural pentacyclic triterpenoid, has been found in various plants including apples, basil, cranberries, peppermint, rosemary, oregano and prunes and has been reported to possess many biological activities, including antioxidant, anti-inflammatory, trypanocidal, antirheumatic, antiviral and antitumoral properties [12,13]. Previous study had revealed that UA ameliorated hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells [14]. However, the molecular mechanisms of CCl 4 -induced liver injury and anti-fibrosis effects of UA are not yet completely understood.…”

Bcl-2 Overexpression Inhibits Generation of Intracellular Reactive Oxygen Species and Blocks Adriamycin-induced Apoptosis in Bladder Cancer Cells

“…Astrocytes overexpressing Bcl-2 exhibited the elevated SOD and GPx activities, but murine lymphoid hematopoietic FL5-12 cells showed no changes in any antioxidant enzyme activity when transfected with Bcl-2 (Brecht et al, 2005). Bcl-2-transfected teratocarcinoma NT-2/D1 and neuroblastoma SK-N-MC cells displayed an increased CuZn-SOD activity, but not those of Mn-SOD, GPx, and GR (Radhiga et al, 2012). In the present study, we found that BIU87-Bcl-2 displayed an increased SOD and CAT activity compared with its parental cells, suggesting that Bcl-2 might inhibit ADR-induced intracellular ROS increasing through the enhancement of both SOD and CAT activities in bladder cancer cells.…”