Effect of Ursodeoxycholic Acid Therapy on Hepatic Function in Children with Intrahepatic Cholestatic Liver Disease
Michael R. Narkewicz,
Debra Smith,
Christopher Gregory
et al.
Abstract:Background:Ursodeoxycholic acid (UDCA) has been shown to improve pruritus, alanine aminotransferase (ALT), and cholesterol levels in children with intrahepatic cholestatic liver disease. However, the effect of UDCA on quantitative tests of hepatic function in children is uncertain.Methods:A 2.5‐year, open label, crossover study, was designed to determine the effect of UDCA (15‐20 mg/kg per day for 12 months, off for 6 months, and on again for 12 months) on clinical symptoms, biochemical test results, galactose… Show more
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