Effect of urodilatin on platelet-activating factor-induced bronchoconstriction, vasoconstriction and edema formation in isolated rat lung

Uhlig, Stefan; Rl, Featherstone; Oh, Wilhelms; Wendel, Albrecht

doi:10.1007/bf00170846

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…The increased levels of ANP seen in sepsis might therefore exert protective effects on pulmonary permeability. Other studies in isolated perfused lungs showed that ANP has no effect on thromboxane-associated increases in pulmonary vascular permeability or may actually increase permeability in noninjured lungs (21,22). The latter findings are in keeping with the data presented here, as the ratio of lymph and plasma protein concentration reached 0.21 Ϯ 0.04 during ANP blockade at 44 hrs.…”

Section: In the Systemic Circulation Infusionsupporting

confidence: 93%

Role of atrial natriuretic peptide in pulmonary permeability and vasoregulation in ovine sepsis

Stubbe

Traber²,

Booke³

et al. 2004

Critical Care Medicine

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Section: In the Systemic Circulation Infusionsupporting

confidence: 93%

Role of atrial natriuretic peptide in pulmonary permeability and vasoregulation in ovine sepsis

Stubbe

Traber²,

Booke³

et al. 2004

Critical Care Medicine

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“…PAF induces broncho-and vasoconstriction primarily by the release of thromboxane, which acts via the TP-R (7,51). Thus pharmacological analysis of PAF-induced broncho-and vasoconstriction has to take into account the fact that the agents tested may interfere not only with the pressor responses, but also with the production of thromboxane.…”

Section: Discussionmentioning

confidence: 99%

Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase

Martin¹,

Göggel²,

Ressmeyer³

et al. 2004

American Journal of Physiology-Lung Cellular and Molecular Phys

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Platelet-activating factor (PAF) contracts smooth muscle of airways and vessels primarily via release of thromboxane. Contraction of smooth muscle is thought to be mediated either by calcium and inositol trisphosphate (IP(3))-dependent activation of the myosin light chain kinase or, alternatively, via the recently discovered Rho-kinase pathway. Here we investigated the contribution of these two pathways to PAF and thromboxane receptor-mediated broncho- and vasoconstriction in two different rat models: the isolated perfused lung (IPL) and precision-cut lung slices. Inhibition of the IP(3) receptor (1-10 microM xestospongin C) or inhibition of phosphatidylinositol-specific PLC (30 microM L-108) did not affect bronchoconstriction but attenuated the sustained vasoconstriction by PAF. Inhibition of myosin light chain kinase (35 microM ML-7) or of calmodulin kinase kinase (26 microM STO609), which regulates the phosphorylation of the myosin light chain, had only a small effect on PAF- or thromboxane-induced pressor responses. Similarly, calmidazolium (10 microM), which inhibits calmodulin-dependent proteins, only weakly reduced the airway responses. In contrast, Y-27632 (10 microM), a Rho-kinase inhibitor, attenuated the thromboxane release triggered by PAF and provided partial or complete inhibition against PAF- and thromboxane-induced pressor responses, respectively. Together, our data indicate that PAF- and thus thromboxane receptor-mediated smooth muscle contraction depends largely on the Rho-kinase pathway.

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Role of natriuretic peptide signaling in modulating asthma and inflammationThis article is one of a selection of papers published in the Special Issue on Recent Advances in Asthma Research.

Mohapatra

2007

Can. J. Physiol. Pharmacol.

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Atrial natriuretic peptide (ANP), the C-terminal peptide comprising residues 99-126 of the pro-ANP hormone, has been studied for 3 decades for its cardiovascular effects. Recent reports suggest that it plays a significant role in modulation of the immune system. Immune cells, including macrophages, dendritic cells, and T lymphocytes, express receptors for ANP. ANP plays a significant role in shaping the early immune response to environmental antigens and may play a critical role in the interaction between cells of the innate and adaptive immune systems; it also appears to be involved in polarizing the immune response to allergens. Thus, ability to alter the magnitude of natriuretic peptide receptor A (NPRA) signaling could be exploited to develop therapeutics for several allergic diseases, including asthma. This report will review and critically evaluate the role of the ANP pathway in asthma and inflammation.

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Effect of urodilatin on platelet-activating factor-induced bronchoconstriction, vasoconstriction and edema formation in isolated rat lung

Cited by 4 publications

References 21 publications

Role of atrial natriuretic peptide in pulmonary permeability and vasoregulation in ovine sepsis

Role of atrial natriuretic peptide in pulmonary permeability and vasoregulation in ovine sepsis

Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase

Role of natriuretic peptide signaling in modulating asthma and inflammationThis article is one of a selection of papers published in the Special Issue on Recent Advances in Asthma Research.

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