Effect of Urinary Cytology for Detecting Recurrence in Remnant Urothelium After Radical Cystectomy: Insights From a 10-year Cytology Database

Pichler, Renate; Tulchiner, Gennadi; Oberaigner, Wilhelm; Schaefer, Georg; Horninger, Wolfgang; Brunner, Andrea; Heidegger, Isabel

doi:10.1016/j.clgc.2017.03.003

Cited by 15 publications

(8 citation statements)

References 45 publications

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“…All included patients received neither neoadjuvant nor adjuvant platinum-based chemotherapy. Follow-up intervals and detailed clinical investigations on surveillance after RC according to our institutional practice have been published recently [ 51 ]. Tumor progression was determined by standard imaging, and histologically confirmed by CT guided biopsy (due to uncertain diagnosis of metastatic lesions) in 27 patients prior to starting first-line chemotherapy…”

Section: Methodsmentioning

confidence: 99%

PD-L1 expression in bladder cancer and metastasis and its influence on oncologic outcome after cystectomy

et al. 2017

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Platinum-based chemotherapy is the standard of care in metastatic bladder cancer. With the approval of various checkpoint inhibitors, immunotherapy has revolutionized the traditional treatment modalities. The aim of the study was to evaluate whether PD-L1 expression on tumor cells (TCs) and tumor-infiltrating immune cells (ICs) can be used as biomarker to predict recurrence-free survival (RFS), overall survival (OS) and disease-specific survival (DSS) in bladder cancer patients after radical cystectomy (RC) developing disease recurrence followed by first-line chemotherapy. PD-L1 was measured on formalin-fixed, paraffin-embedded tissue sections of RC specimens in all patients (n=61) and in 27 matched metastatic biopsy samples by immunohistochemistry. PD-L1 expression on TCs was defined by the percentage of PD-L1 positive tumor cells (< 1%= IC0, ≥1% but <5%=IC1, ≥5 %=IC2/3), and was considered negative or positive for ICs. On 27 paired samples, IC1/2/3 score on TCs was homogeneous distributed with 59.3% in primary tumors and metastases, but with a high discordance rate of 44.4% of PD-L1 positivity on ICs. High PD-L1 expression (IC2/3) on TCs was more frequently seen in histologic subtypes of urothelial cancer compared to pure urothelial cancers (46.2% vs. 20.8%; p=0.002). PD-L1 expression on TCs in primary tumors (IC2/3 vs. IC0, median: 3.2 vs. 13.8 months, p=0.019) and metastatic sites (IC2/3 vs. IC0, median: 6.1 vs. 21.8 months, p=0.014) was associated with poor chemo-response, represented by significant shortened DSS. These results suggest that PD-L1 may be a potential target being involved in chemo-resistance mechanisms and poses potential for therapy stratification in the future.

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Section: Methodsmentioning

confidence: 99%

PD-L1 expression in bladder cancer and metastasis and its influence on oncologic outcome after cystectomy

et al. 2017

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“…Based on these findings, urine cytology has been proposed to be a part of the oncological surveillance protocol for early detection of UR after radical cystectomy. [ 7 ] A periodic cytological follow-up program had been planned for the patient that we presented. However, he did not comply with the controls and was admitted symptomatically 4 years after the operation.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] The most common treatment method of cases with invasive recurrent urethral tumors, like that of our case, is urethrectomy occasionally accompanied by chemotherapy or radiation therapy. [ 7 - 9 ] In some specific cases, other treatments such as transurethral resection, penectomy, and emasculation may be performed. BCG administration is a treatment choice for urethral tumors diagnosed at early pathological stages.…”

Section: Discussionmentioning

confidence: 99%

Urethral Recurrence of Urothelial Carcinoma of the Bladder Following Radical Cystectomy: An Unusual Imaging Pattern

Özdemir

Kavak

Eren

2020

JCIS

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Residual urethra is a common site of recurrence in patients undergoing radical cystectomy with urinary diversion for bladder cancer. Urethral recurrence (UR) clinically manifests as a penile mass or a bloody or purulent penile discharge at a median of 13 months after surgery. And on imaging studies, it characteristically appears as a focal intraluminal mass, urethral wall thickening, or an infiltrating mass arising from the urethra. We, herein, present an unusual case of UR manifesting as a large cyst in the penile root 4 years after radical cystectomy with urinary diversion for muscle-invasive bladder cancer. Further, a complex cystic mass developed in the same location 2 years after the excision of the cystic UR. This case shows that the imaging spectrum of UR after radical cystectomy may be wider and may include cystic and complex patterns.

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“…Recurrences can occur in the bladder and throughout the urinary tract including the urethra. Urethral recurrence after radical cystectomy (RC) without urethrectomy is frequently reported in the literature 1 and is considered an indicator of poor survival 2,3 . Risk factors for urethral cancer recurrence after RC include tumors in the trigone of the urinary bladder, multiple or recurrent 4 tumors, non‐papillary bladder tumors, 5 and bladder CIS.…”

Section: Introductionmentioning

confidence: 99%

Prostatic urethra recurrence after transurethral resection of bladder tumor (TURBT) for non‐muscle‐invasive bladder cancer (NMIBC)

Bilim

Hoshi²

2022

Clinical Case Reports

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Effect of Urinary Cytology for Detecting Recurrence in Remnant Urothelium After Radical Cystectomy: Insights From a 10-year Cytology Database

Abstract: Our results underline the predictive value of UCy in the surveillance of the remnant urothelium, with early detection of urethral recurrence before the development of clinical symptoms.

Cited by 15 publications

References 45 publications

PD-L1 expression in bladder cancer and metastasis and its influence on oncologic outcome after cystectomy

PD-L1 expression in bladder cancer and metastasis and its influence on oncologic outcome after cystectomy

Urethral Recurrence of Urothelial Carcinoma of the Bladder Following Radical Cystectomy: An Unusual Imaging Pattern

Prostatic urethra recurrence after transurethral resection of bladder tumor (TURBT) for non‐muscle‐invasive bladder cancer (NMIBC)

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