Effect of Urate on Nitric Oxide Microcirculatory Response in the Rat Tail to Body Heating

Widanski, Bozena; Richardson, Daniel R.; Bruckner, Géza

doi:10.1038/sj.mn.7800125

Cited by 1 publication

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“…In our study, the average temperature of the T1D patients during exercise was 37.8 ± 0.8 ° C, which may have been an important stimulus for the changes in capillary perfusion. In this sense, because it has been shown that physiological levels of urate are needed to promote increases in capillary perfusion in thermal stress situations [ 67 ], it is reasonable to speculate that the decrease in uric acid levels represents improvements in perfusion associated with the adaptive effects of low intensity training and resulting in capillary angiogenic processes.…”

Section: Discussionmentioning

confidence: 99%

Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study

Moraes

Bavel

Gomes

et al. 2016

BMC Cardiovasc Disord

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BackgroundThe aim of the present study was to evaluate changes in microvascular density and reactivity in patients with type 1 diabetes (T1D) resulting from low intensity chronic exercise training.MethodsThis study included 22 (34 ± 7 years) consecutive outpatients with T1D and disease duration > 6 years. We used intravital video-microscopy to measure basal skin capillary density and capillary recruitment using post-occlusive reactive hyperemia (PORH) in the dorsum of the fingers. Endothelium-dependent and -independent vasodilation of the skin microcirculation was evaluated in the forearm with a laser Doppler flow monitoring (LDF) system in combination with acetylcholine and sodium nitroprusside iontophoresis, PORH and local thermal hyperemia.ResultsThe basal mean capillary density (MCD) after exercise training was significantly higher than before exercise (134 ± 25 vs. 119 ± 19 capillaries/mm2, respectively; P = 0.0013). MCD during PORH was also higher after exercise (140 ± 26 vs. 121 ± 24 capillaries/mm2, respectively; P < 0.0001). Endothelium-dependent capillary recruitment during PORH was also significantly higher after exercise (140 ± 26 vs. 134 ± 25 capillaries/mm2, respectively; P < 0.0012). There were no significant changes in skin microvascular reactivity after exercise as investigated using LDF.ConclusionsOur results showed that low intensity aerobic exercise, performed four times per week for 12 weeks by patients with T1D, induces significant increases in microvascular density and endothelial-dependent capillary reactivity.Trial registrationClinicalTrials.gov NCT02441504. Registered 7 May 2015.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0191-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study

Moraes

Bavel

Gomes

et al. 2016

BMC Cardiovasc Disord

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Effect of Urate on Nitric Oxide Microcirculatory Response in the Rat Tail to Body Heating

Abstract: Urate at physiological concentration helps to maintain vascular conductance of cutaneous capillaries in the rat tail during body heating. The effect of urate on vascular conductance may be mediated by NO.

Cited by 1 publication

References 27 publications

Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study

Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study

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