Effect of upregulated renin–angiotensin system on per2 and bmal1 gene expression in brain structures involved in blood pressure control in TGR(mREN-2)27 rats

Monošíková, Jana; Herichová, Iveta; Mravec, Boris; Kiss, Alexander; Zeman, Michal

doi:10.1016/j.brainres.2007.08.061

Cited by 16 publications

(25 citation statements)

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“…The reasons why the inverted BP develops are not clear, but the role of interactions between the circadian cycle, RAS, and autonomous nervous system are considered (Lemmer et al 2003;Monosíková et al 2007). It is assumed that all the above mentioned systems may interact at the level of different brain ''nodal'' structures (Monosíková et al 2007). Present data demonstrate a robust circadian variation in the per1 mRNA expression in the central circadian oscillator (SCN) and a low-amplitude rhythm in the PVN.…”

Section: Discussionmentioning

confidence: 81%

“…Hypertension and the inverted BP profile were proven in our present experiment in TGR rats. The reasons why the inverted BP develops are not clear, but the role of interactions between the circadian cycle, RAS, and autonomous nervous system are considered (Lemmer et al 2003;Monosíková et al 2007). It is assumed that all the above mentioned systems may interact at the level of different brain ''nodal'' structures (Monosíková et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Although the mechanisms, leading to the development of the inverted BP rhythm, have been extensively studied at different levels (Lemmer et al 2003, for review), they are still not fully understood. It is assumed that the inverted BP profile emanates from the interaction of at least three systems: i.e., the RAS, autonomous sympathetic nervous system, and circadian system (Monosíková et al 2007;Zeman et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the destruction of the SCN in TGR rats does not result in normal BP circadian pattern (Witte et al 1998), which may indicate that other brain structures could be responsible for the inverted BP rhythm observed in TGR rats. Circadian expression of clock genes in different brain areas involved in the BP control differs between TGR and control rats with the most robust difference found in the area postrema (Monosíková et al 2007), i.e., in one of the circumventricular organs located on the dorsal side of the medulla oblongata at the caudal end of the fourth ventricle.…”

Section: Introductionmentioning

confidence: 99%

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Expressions of per1 Clock Gene and Genes of Signaling Peptides Vasopressin, Vasoactive Intestinal Peptide, and Oxytocin in the Suprachiasmatic and Paraventricular Nuclei of Hypertensive TGR[mREN2]27 Rats

et al. 2010

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Hypertensive rats with multiple extra copies of the renin gene (TGR) exert an inverted circadian blood pressure (BP) profile. We investigated whether circadian oscillations in the hypothalamic suprachiasmatic nucleus (SCN), a main circadian oscillator, and the paraventricular nucleus (PVN), involved in BP control, are influenced in TGR rats. The expression of the clock gene per1, a marker of circadian timing, was measured in the SCN and PVN. Moreover, the expression of genes encoding vasopressin (AVP), vasoactive intestinal peptide (VIP) in the SCN, and AVP and oxytocin (OXT) in the PVN were studied by in situ hybridization. Expression of the per1 gene showed a distinct circadian rhythm in both the SCN and PVN with no differences observed between the TGR and control Sprague–Dawley (SD) rats. The expression of avp in the SCN was rhythmic in both strains and moderately higher in TGR than in SD rats while no significant changes were found in the PVN. The expression of vip in the SCN and oxt in the PVN did not differ between both strains. Our results may indicate that changes occurring downstream to the SCN are responsible for the development of the inverted BP rhythm in TGR hypertensive rats.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expressions of per1 Clock Gene and Genes of Signaling Peptides Vasopressin, Vasoactive Intestinal Peptide, and Oxytocin in the Suprachiasmatic and Paraventricular Nuclei of Hypertensive TGR[mREN2]27 Rats

et al. 2010

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“…24 The sympathetic system and the renin-angiotensinaldosterone system are also closely related, and inhibition of the sympathetic system may diminish renin-angiotensin-aldosterone system activity and vice versa. Expression of the clock genes in the brain areas involved in BP control 25 as well as expression of genes encoding enzymes from the catecholamine biosynthetic pathway were disturbed in TGR rats. 26 Thus, direct measurement of tyrosine hydroxylase activity would be useful to directly clarify the mechanism; further investigation is needed.…”

Section: Discussionmentioning

confidence: 98%

A critical role of sympathetic nerve regulation for the treatment of impaired daily rhythm in hypertensive Dahl rats

et al. 2010

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There is a deep relationship between impaired circadian rhythm and hypertension. However, the detailed mechanisms between the daily sleep-wake rhythm and cardiovascular disorders have not yet been elucidated. To clarify the mechanism, we examined salt-sensitive Dahl rats that were fed normal chow (n¼10), high-salt chow (n¼10) and high-salt chow with bisoprolol (n¼10). Simultaneous electroencephalogram, electromyogram and locomotor activity were examined to analyze the sleep-wake state. We also examined heart rate, blood pressure and echocardiographic findings to verify the presence of hypertension. Hypertension with impaired ventricular contraction was observed in the rats with high-salt-chow consumption whereas normal-chow rats did not show these disorders. Although rats with the normal diet showed a standard daily rhythm with normal rapid eye movement (REM) sleep duration and locomotor activity, the high-salt-diet group exhibited an impaired daily rhythm with suppressed REM sleep and significant abnormal locomotor activity. Bisoprolol significantly improved the daily sleep-wake rhythm and locomotor activity. We showed that an impaired daily rhythm was closely related to the development of hypertension. Keywords: b-blocker; daily rhythm; locomotor activity INTRODUCTION It is well known that there is a deep relationship between sleep disorders and cardiovascular diseases such as hypertension and congestive heart failure (CHF). The fact that patients with advanced CHF induced by hypertension frequently suffer from central breathing disorders 1 suggests that CHF is causally related to alterations in the central control of breathing, resulting in Cheyne-Stokes respiration during sleep. 2 Disorders in the central control of breathing are a key factor in altered daily sleep-wake rhythm and are also an independent predictor for premature death. 3,4 Although it is known that cardiovascular diseases are closely related to circadian rhythm, 5 the relationship among changes in circadian rhythm, sleep disorders and cardiovascular diseases has not yet been elucidated.It has been reported that long-term treatment with b-receptorblocking substances (b-blockers) improves hypertension and CHF. bBlockers also reduce the inappropriate increase of ventilation during exercise and alleviate central breathing disorders during wakefulness. 6,7 These positive effects result in improved exercise capacity and slower progression of underlying hypertension and CHF. However, little is known about the effects of b-blocker treatment on sleep

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Animal Models for the Study of Neurohumeral and Central Neural Control of the Cardiovascular System

Gross

2009

Animal Models in Cardiovascular Research

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Effect of upregulated renin–angiotensin system on per2 and bmal1 gene expression in brain structures involved in blood pressure control in TGR(mREN-2)27 rats

Cited by 16 publications

References 42 publications

Expressions of per1 Clock Gene and Genes of Signaling Peptides Vasopressin, Vasoactive Intestinal Peptide, and Oxytocin in the Suprachiasmatic and Paraventricular Nuclei of Hypertensive TGR[mREN2]27 Rats

Expressions of per1 Clock Gene and Genes of Signaling Peptides Vasopressin, Vasoactive Intestinal Peptide, and Oxytocin in the Suprachiasmatic and Paraventricular Nuclei of Hypertensive TGR[mREN2]27 Rats

A critical role of sympathetic nerve regulation for the treatment of impaired daily rhythm in hypertensive Dahl rats

Animal Models for the Study of Neurohumeral and Central Neural Control of the Cardiovascular System

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