“…The aim of the present work is to examine whether these same conclusions hold for macrocycles that assemble into porous frameworks in the solid state. For example, the [18]annulene molecule (Figure b) packs in such a way that the π system of one monomer lies atop the pore of the neighboring monomer, in a form of offset-stacking. , The boron-based covalent organic framework (COF) material known as COF-1, a truncated “monomer” unit of which is shown in Figure d, forms alternating layers that may or may not have an offset, as the bulk materials are amorphous or polycrystalline and in some cases the microdomains are sensitive to the presence or absence of solvent molecules occupying the pore. − For applications in catalysis, it is desirable that the pores be accessible, but while it has been suggested that most COF materials exhibit eclipsed-cofacial stacking , (sometimes called “AA” stacking, borrowing the nomenclature used for graphene), , detailed analysis of powder diffraction along with theoretical calculations suggests that slipped- or offset-stacking (sometimes called “inclined stacking”) is common. − ,− The preference for eclipsed-cofacial (“AA”) versus fully staggered (“AB”) stacking may be controllable via functionalization …”