Effect of University of Wisconsin and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Blood Potassium Levels of Patients Undergoing Living-Donor Liver Transplantation

Juang, Sin-Ei; Huang, Hung-Yu; Kao, Chuan-Chi; Chen, C.-L.; Lu, Hung-Yi; Cheng, K.-W.; Huang, Chia-Jung; Wu, Shao-Chun; Jawan, Bruno; Wang, C.-H.

doi:10.1016/j.transproceed.2011.12.061

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…19 It must be noted that, due to logistical differences between postmortal and living donor liver transplantations, cold ischemia times (mean 66 minutes) in this study were substantially shorter than cold ischemia times in our study groups. One previous study reported a slight decrease in potassium levels after reperfusion of UW-preserved liver grafts compared to histidine-tryptophan-ketoglutarate solution in adult F I G U R E 6 Overview of potassium and sodium shifts during organ preservation and subsequent warm reperfusion.…”

Section: Discussioncontrasting

confidence: 54%

“…UW, University of Wisconsin; SCS solution, static cold storage solution; MP solution, machine perfusion solution living donor liver transplantations. 19 It must be noted that, due to logistical differences between postmortal and living donor liver transplantations, cold ischemia times (mean 66 minutes) in this study were substantially shorter than cold ischemia times in our study groups. In pediatric liver transplantation, hypokalemia after graft reperfusion is more commonly seen.…”

Section: Discussioncontrasting

confidence: 54%

“…Moreover, high potassium levels upon ex situ reperfusion strongly predicted high peak ALT levels (P < .001) and peak lactate levels (P < .001) ( Table 2). (16)(17)(18)(19)(20)(21)(22)(23) .49…”

Section: Correlation Between Changes In Cation Levels and Postrepermentioning

confidence: 99%

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Opposite acute potassium and sodium shifts during transplantation of hypothermic machine perfused donor livers

Burlage

Hessels

Rijn

et al. 2019

American Journal of Transplantation

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Liver transplantation is frequently associated with hyperkalemia, especially after graft reperfusion. Dual hypothermic oxygenated machine perfusion (DHOPE) reduces ischemia/reperfusion injury and improves graft function, compared to conventional static cold storage (SCS). We examined the effect of DHOPE on ex situ and in vivo shifts of potassium and sodium. Potassium and sodium shifts were derived from balance measurements in a preclinical study of livers that underwent DHOPE (n = 6) or SCS alone (n = 9), followed by ex situ normothermic reperfusion. Similar measurements were performed in a clinical study of DHOPE‐preserved livers (n = 10) and control livers that were transplanted after SCS only (n = 9). During DHOPE, preclinical and clinical livers released a mean of 17 ± 2 and 34 ± 6 mmol potassium and took up 25 ± 9 and 24 ± 14 mmol sodium, respectively. After subsequent normothermic reperfusion, DHOPE‐preserved livers took up a mean of 19 ± 3 mmol potassium, while controls released 8 ± 5 mmol potassium. During liver transplantation, blood potassium levels decreased upon reperfusion of DHOPE‐preserved livers while levels increased after reperfusion of SCS‐preserved liver, delta potassium levels were ‐0.77 ± 0.20 vs. +0.64 ± 0.37 mmol/L, respectively (P = .002). While hyperkalemia is generally anticipated during transplantation of SCS‐preserved livers, reperfusion of hypothermic machine perfused livers can lead to decreased blood potassium or even hypokalemia in the recipient.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussioncontrasting

confidence: 54%

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Opposite acute potassium and sodium shifts during transplantation of hypothermic machine perfused donor livers

Burlage

Hessels

Rijn

et al. 2019

American Journal of Transplantation

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“…Jain et al prospectively studied 33 LDLTs, revealing comparable hepatic function. Nonetheless a recent comparison of University of Wisconsin and HTK solutions in LDLTs found serum potassium levels were both within normal range following reperfusion consistent with comparable clinical stability [52]. Other reports have noted greater hemodynamic changes after flush with HTK solution in LDLT versus University of Wisconsin solution [51].…”

Section: Livermentioning

confidence: 66%

Preservation solutions for static cold storage of abdominal allografts

Parsons

Guarrera

2014

Current Opinion in Organ Transplantation

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“…As expected, in our study, intraoperative potassium levels were higher in the UW group, though both preservation solutions maintained patient potassium levels within the normal range and of low clinical relevance. is can be related to high potassium content in UW solution, although there is no evidence that this is reflected in a higher serum potassium level in the recipient following reperfusion [16]. Despite routine use of Ringer acetate or blood to flush out UW solution from the preserved organ prior to reperfusion, a significant amount of UW solution remains in the organ, from where it is released into the recipient's blood stream after organ reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Type of Preservation Solution, UW or HTK, Has an Impact on the Incidence of Biliary Stricture following Liver Transplantation: A Retrospective Study

Karakoyun

Nordström

Ericzon

et al. 2019

Journal of Transplantation

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Organ preservation plays a crucial role in the outcome following solid organ transplantation. The aim of this study was to perform a retrospective outcome analysis following liver transplantation using histidine tryptophan ketoglutarate (HTK) or the University of Wisconsin (UW) solutions for liver graft preservation. We retrospectively reviewed data on adult patients who were liver-transplanted at Karolinska University Hospital between 2007 and 2015. There was evaluation of donor and recipient characteristics, pre- and post-transplant blood chemistry tests, biliary and vascular complications, graft dysfunction and nonfunction, and patient and graft survivals. A total of 433 patients were included in the analyses, with 230 and 203 patients having received livers preserved with HTK and UW, respectively. Mean follow-up was 45 ± 29 months for the HTK group and 42.4 ± 26 for the UW group. There was no difference between the two groups either in terms of patient and graft survival, or of results of postoperative blood chemistry, or incidence of arterial complications, early allograft dysfunction, or primary graft nonfunction. However, the incidence of biliary stricture was higher in the UW group (22.7%) versus the HTK group (13.5%; p=0.013). Use of UW and HTK preservation solution in liver transplantation has no impact on patient and graft survival. However, use of HTK solution results in a lower incidence of posttransplant biliary stricture.

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Effect of University of Wisconsin and Histidine-Tryptophan-Ketoglutarate Preservation Solutions on Blood Potassium Levels of Patients Undergoing Living-Donor Liver Transplantation

Cited by 7 publications

References 8 publications

Opposite acute potassium and sodium shifts during transplantation of hypothermic machine perfused donor livers

Opposite acute potassium and sodium shifts during transplantation of hypothermic machine perfused donor livers

Preservation solutions for static cold storage of abdominal allografts

Type of Preservation Solution, UW or HTK, Has an Impact on the Incidence of Biliary Stricture following Liver Transplantation: A Retrospective Study

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