Effect of Unilateral Temporal Lobe Resection on Short‐Term Memory for Auditory Object and Sound Location

Lancelot, Céline; Samson, Séverine; Ahad, Pierre; Baulac, Michel

doi:10.1196/annals.1284.046

Cited by 10 publications

(10 citation statements)

References 9 publications

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“…Human neuroimaging studies have reported activation of MTL during working memory (WM) tasks that engage informational encoding (Campo et al 2005; Karlsgodt et al 2005; Mainy et al 2007), maintenance of information (Ranganath and D'Esposito 2001; Axmacher et al 2007), and retrieval (Cabeza et al 2002; Schon et al 2009). Also supporting this view, neuropsychological and neuroimaging studies have revealed impaired performance and abnormalities in MTL activity during WM tasks in patients with MTL damage with various causes (Owen et al 1996; Krauss et al 1997; Abrahams et al 1999; Grady et al 2001; Lancelot et al 2003; Lee et al 2006; Olson et al 2006; Piekema et al 2007; Ezzyat and Olson 2008; Wagner et al 2009). However, based on the assumption that cognitive processes engage distributed neural networks, if we want to gain a clearer understanding of the functional role of MTL in WM it cannot be considered as an independent processor.…”

Section: Introductionmentioning

confidence: 75%

Remote Effects of Hippocampal Sclerosis on Effective Connectivity during Working Memory Encoding: A Case of Connectional Diaschisis?

et al. 2011

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Accumulating evidence suggests a role for the medial temporal lobe (MTL) in working memory (WM). However, little is known concerning its functional interactions with other cortical regions in the distributed neural network subserving WM. To reveal these, we availed of subjects with MTL damage and characterized changes in effective connectivity while subjects engaged in WM task. Specifically, we compared dynamic causal models, extracted from magnetoencephalographic recordings during verbal WM encoding, in temporal lobe epilepsy patients (with left hippocampal sclerosis) and controls. Bayesian model comparison indicated that the best model (across subjects) evidenced bilateral, forward, and backward connections, coupling inferior temporal cortex (ITC), inferior frontal cortex (IFC), and MTL. MTL damage weakened backward connections from left MTL to left ITC, a decrease accompanied by strengthening of (bidirectional) connections between IFC and MTL in the contralesional hemisphere. These findings provide novel evidence concerning functional interactions between nodes of this fundamental cognitive network and sheds light on how these interactions are modified as a result of focal damage to MTL. The findings highlight that a reduced (top-down) influence of the MTL on ipsilateral language regions is accompanied by enhanced reciprocal coupling in the undamaged hemisphere providing a first demonstration of “connectional diaschisis.”

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Section: Introductionmentioning

confidence: 75%

Remote Effects of Hippocampal Sclerosis on Effective Connectivity during Working Memory Encoding: A Case of Connectional Diaschisis?

et al. 2011

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“…These studies found that TLE patients after ATL present no deficit in a simple pitch discrimination task (Johnsrude et al, 2000), but impairments in short-term memorisation of harmonic sound pitch (Zatorre and Samson, 1991) and of bird songs (Lancelot et al, 2003). Our results after ATL are consistent with these previous works, but since we already observed similar deficits in TLE patients before surgery, our findings further suggest that auditory deficits observed in TLE patients after ATL are most likely due to the epilepsy itself than to the brain resection.…”

Section: Discussionmentioning

confidence: 99%

Non-verbal auditory cognition in patients with temporal epilepsy before and after anterior temporal lobectomy

Bidet-Caulet

Bouchet

et al. 2009

Front. Hum. Neurosci.

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For patients with pharmaco-resistant temporal epilepsy, unilateral anterior temporal lobectomy (ATL) – i.e. the surgical resection of the hippocampus, the amygdala, the temporal pole and the most anterior part of the temporal gyri – is an efficient treatment. There is growing evidence that anterior regions of the temporal lobe are involved in the integration and short-term memorization of object-related sound properties. However, non-verbal auditory processing in patients with temporal lobe epilepsy (TLE) has raised little attention. To assess non-verbal auditory cognition in patients with temporal epilepsy both before and after unilateral ATL, we developed a set of non-verbal auditory tests, including environmental sounds. We could evaluate auditory semantic identification, acoustic and object-related short-term memory, and sound extraction from a sound mixture. The performances of 26 TLE patients before and/or after ATL were compared to those of 18 healthy subjects. Patients before and after ATL were found to present with similar deficits in pitch retention, and in identification and short-term memorisation of environmental sounds, whereas not being impaired in basic acoustic processing compared to healthy subjects. It is most likely that the deficits observed before and after ATL are related to epileptic neuropathological processes. Therefore, in patients with drug-resistant TLE, ATL seems to significantly improve seizure control without producing additional auditory deficits.

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“…Moreover, Pinek et al (1989) reported that sound lateralisation deficits occur in both hemifields, especially after left hemisphere damage; in contrast, (Ruff et al, 1981) stated that deficits occur primarily after right hemisphere damage. These and similar diverse findings in the literature may be attributed to localisation of the individual lesions in different cortical regions such as temporal (Clarke et al, 2000) or parietal lobes (Griffiths et al, 1998), and to differences in experimental paradigms that may involve auditory short-term memory (Lancelot et al, 2003) or psychophysical explorations (Griffiths et al, 1997), as well as to differences in imaging techniques employed, such as magnetic resonance imaging (Zatorre and Penhune, 2001) and positron emission tomography (Weeks et al, 1999).…”

Section: Introductionmentioning

confidence: 63%

Lateralisation of sound in temporal-lobe epilepsy: Comparison between pre- and postoperative performances and ERPs

Tezer

İlhan

Erbil

et al. 2012

Clinical Neurophysiology

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Effect of Unilateral Temporal Lobe Resection on Short‐Term Memory for Auditory Object and Sound Location

Cited by 10 publications

References 9 publications

Remote Effects of Hippocampal Sclerosis on Effective Connectivity during Working Memory Encoding: A Case of Connectional Diaschisis?

Remote Effects of Hippocampal Sclerosis on Effective Connectivity during Working Memory Encoding: A Case of Connectional Diaschisis?

Non-verbal auditory cognition in patients with temporal epilepsy before and after anterior temporal lobectomy

Lateralisation of sound in temporal-lobe epilepsy: Comparison between pre- and postoperative performances and ERPs

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