Effect of umbilical cord mesenchymal stem cells on treatment of severe acute pancreatitis in rats

Yang, Bin; Bai, Bin; Liu, Chao-Xu; Wang, Shi-qi; Xue, Jiang; Zhu, Cailin; Zhao, Qingchuan

doi:10.1016/j.jcyt.2012.11.007

Cited by 41 publications

(52 citation statements)

References 22 publications

(21 reference statements)

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“…32,33 Recently, therapeutic effects of human MSCs derived from bone marrow and umbilical cord on acute pancreatitis in rats have been reported. 29,34,35 In our study, rat FM-MSCs led to lower histological scoring and suppressed inflammatory cell infiltration in the acute pancreatitis model. Pancreatic stellate cells (PSCs) play a pivotal role in the pathogenesis of chronic pancreatitis.…”

Section: Discussionsupporting

confidence: 48%

Effect of Fetal Membrane-Derived Mesenchymal Stem Cell Transplantation in Rats With Acute and Chronic Pancreatitis

et al. 2016

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Section: Discussionsupporting

confidence: 48%

Effect of Fetal Membrane-Derived Mesenchymal Stem Cell Transplantation in Rats With Acute and Chronic Pancreatitis

et al. 2016

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“…It was demonstrated that bmMSCs could not migrate into pancreatic when they infused into intraperitoneal. In this study, we also confirmed that bmMSCs infusion significantly decreased serum amylase and lipase, relieved pancreatic lesions (edema, necrosis and inflammatory cell infiltration) caused by injection of sodium taurocholate [16,18]. And we observed the better recovery of damaged pancreas when we transplanted bmMSCs through the tail vein+ intraperitoneal compared with through tail vein or intraperitoneal alone.…”

Section: Discussionsupporting

confidence: 76%

“…To date, accumulated evidence from preclinical and linical studies has confirmed that MSCs conferred biological and functional protections in diabetes, myocardium infarction, brain and spinal cord injury etc [15]. In re-sent years some experiment have reported the protective roles of MSCs in AP [16][17][18][19][20] MSCs infusion through tail vein can protect the structural integration of acinar cells, promoted pancreatic angiogenesis, significantly inhibited inflammation and attenuate acinar cell apoptosis. Sun XC found that intraperitoneal injection of MSCs exerted protective effects on pancreas and small intestine injury [21].…”

Section: Discussionmentioning

confidence: 99%

Experimental Study on Bone Marrow Mesenchymal Stem Cells for the Treatment of Acute Pancreatitis in Rats

Chen¹

2018

MOJABB

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Explored the appropriate way for bone marrow mesenchymal stem cells (bmMSCs) infuse in rat models of severe acute pancreatitis. Severe AP was induced in Sprage-Dawley rats by the sodium taurocholate bile duct retrograde injection. Rats were randomly divided into five groups: control group, SAP group, SAP +bmMSCs (tail vein) group, SAP + bmMSCs (intraperitoneal) group and SAP + bmMSCs (tail vein + intraperitoneal) group. In bmMSCs infused groups, bmMSCs labeled with DAPI were injected via the tail vein, intraperitoneal and via tail vein + intraperitoneal respectively 3 h after SAP. Rats were sacrificed on days 1, 2 and 3, and pancreatic tissues and the blood were collected. The levels of serum anti-inflammatory cytokines IL-10 and inflammatory cytokines (IL-1β, TNF-α, IL-6) were determined. Pathological changes of the pancreas (HE staining) were observed under light microscope. Positioning of DAPI labeled bmMSCs in vivo were detected under fluorescence microscope at the same time. The pancreas in SAP group showed significantly massive hemorrhage, edema, inflammation, and necrosis compared with control group. The inflammation, edema, hemorrhage and necrosis in each model of pancreatitis were reduced significantly in SAP+bmMSCs group as compared to SAP group (P<0.05). In bmMSCs transplanted group, bmMSCs remarkably reduced the levels of proinflammatory cytokines (TNF-α, IL-6, and IL-1β), on the contrary increased the levels of anti-inflammatory cytokines (IL-10) in SAP rats. Infused bmMSCs through tail vein + intraperitoneal indicate a better recovery than through tail vein or intraperitoneal alone. Compared with intraperitoneal injection method, more bmMSCs were observed to be presented in pancreas when bmMSCs were injected through tail vein + intraperitoneal or tail vein injection. In a rat model of SAP, transplantation of bm-MSCs through tail vein + intraperitoneal significantly inhibits inflammation and decreases pancreatic injury secondary to SAP. It was a better method for pancreatitis.

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“…Several studies have reported that MSCs suppress serum and pancreatic levels of pro-inflammatory cytokines and increase anti-inflammatory cytokines [24,26]. Yang et al reported that the anti-inflammatory effect of MSC transplantation is time-and dose-dependent [27]. (Fig.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Mesenchymal stem cell therapy for acute and chronic pancreatitis

et al. 2017

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Mesenchymal stem cells (MSCs) have attracted attention as a cell source for regenerative medicine. In particular, MSCs have an anti-inflammatory effect by secreting several kinds of bioactive molecules. MSC therapy is now being applied to various gastrointestinal diseases, such as graft-versus-host disease, inflammatory bowel disease, and liver cirrhosis. Therefore, MSC therapy has the potential to be a novel treatment for acute and chronic pancreatitis by suppressing inflammation. Several studies have investigated the effect of MSC therapy on acute and chronic pancreatitis, but the underlying mechanisms remain unknown. In this review, we summarize the present status of MSC therapy for acute and chronic pancreatitis.

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Effect of umbilical cord mesenchymal stem cells on treatment of severe acute pancreatitis in rats

Cited by 41 publications

References 22 publications

Effect of Fetal Membrane-Derived Mesenchymal Stem Cell Transplantation in Rats With Acute and Chronic Pancreatitis

Effect of Fetal Membrane-Derived Mesenchymal Stem Cell Transplantation in Rats With Acute and Chronic Pancreatitis

Experimental Study on Bone Marrow Mesenchymal Stem Cells for the Treatment of Acute Pancreatitis in Rats

Mesenchymal stem cell therapy for acute and chronic pancreatitis

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