Effect of ultrasound on anti-solvent crystallization process

Guo, Zhengxiao; Zhang, M.; Li, H.; Wang, J.; Kougoulos, E.

doi:10.1016/j.jcrysgro.2004.09.049

Cited by 192 publications

(123 citation statements)

References 14 publications

(17 reference statements)

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“…It can also alter the crystal habit as the ultrasound can increase or decrease the growth rate of certain crystal faces. Localized hot spots may influence the crystal lattice and have some effect on the crystal habit change due to abrasion [13].…”

Section: Ultrasound Assisted Antisolvent Crystallizationmentioning

confidence: 99%

Antisolvent Crystallization of Poorly Water Soluble Drugs

Lonare¹,

Patel²

2013

IJCEA

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Abstract-The enhancement in bioavailability of the drugs is one of the most important concerning aspects of the pharmaceutical industries. Preparation of nanoparticles or microparticles of these drugs is the newest formulation strategies. The size and morphology of a drug are affecting several essential pharmaceutical properties. In general, the drug delivery system needs narrow particle size distribution with regular particle shape, particularly, an engineered drug particles to meet biopharmaceutical and processing needs. An antisolvent crystallization technique is being used to prepare nanoparticles or microparticles for poorly water soluble drugs at research scale. This method has an ability to change the solid-state properties of pharmaceutical substances including the modification of crystal formation and particle size distributions. Therefore, various operating variables and their effect on the particle size of poorly water soluble drugs in an anti-solvent crystallization have been reviewed.

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Section: Ultrasound Assisted Antisolvent Crystallizationmentioning

confidence: 99%

Antisolvent Crystallization of Poorly Water Soluble Drugs

Lonare¹,

Patel²

2013

IJCEA

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“…Ultrasound application results in a dramatic reduction in induction period, metastable zone width and altered supersaturation conditions. [10][11][12][13] This will have significant effect on co-crystallization process of non-congruent system like caffeine -maleic acid. The sonochemistry reports available to date on co-crystallization of caffeine -maleic acid have used organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization

Apshingekar

Aher

Kelly

et al. 2017

Journal of Pharmaceutical Sciences

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ABSTRACT:A green approach has been used for co-crystallization of non-congruent co-crystal pair of caffeinemaleic acid using water. Ultrasound is known to affect crystallization hence the effect of high power ultrasound on the ternary phase diagram has been investigated in detail using a slurry co-crystallization approach. A systematic investigation was performed to understand how the accelerated conditions during ultrasound assisted co-crystallization will affect different regions of the ternary phase diagram.Application of ultrasound showed considerable effect on the ternary phase diagram; principally on caffeine/maleic acid 2:1 (disappeared) and 1:1 co-crystal (narrowed) regions. Also, the stability regions for pure caffeine and maleic acid in water were narrowed in the presence of ultrasound, expanding the solution region. The observed effect of ultrasound on the phase diagram was correlated with solubility of caffeine and maleic acid and stability of co-crystal forms in water.

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“…This usually takes place by disrupting the crystal agglomerates and by intensifying adsorption of polymer on the newly formed crystal surface, thereby reducing the surface energy (34) resulting in smaller crystal size with uniform size distribution (35,36). In case of wet media milling, size reduction (formation of new surface) is achieved by collision between adjacent crystal or crystal and wall of the milling chamber or compression of crystals between adjacent grinding balls.…”

Section: Characterization Of Nanocrystalsmentioning

confidence: 99%

Ultra Rapidly Dissolving Repaglinide Nanosized Crystals Prepared via Bottom-Up and Top-Down Approach: Influence of Food on Pharmacokinetics Behavior

2014

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Abstract. The present work was undertaken with the objectives of improving the dissolution velocity, related oral bioavailability, and minimizing the fasted/fed state variability of repaglinide, a poorly watersoluble anti-diabetic active by exploring the principles of nanotechnology. Nanocrystal formulations were prepared by both top-down and bottom-up approaches. These approaches were compared in light of their ability to provide the formulation stability in terms of particle size. Soluplus® was used as a stabilizer and Kolliphor™ E-TPGS was used as an oral absorption enhancer. In vitro dissolution profiles were investigated in distilled water, fasted and fed state simulated gastric fluid, and compared with the pure repaglinide. In vivo pharmacokinetics was performed in both the fasted and fed state using Wistar rats. Oral hypoglycemic activity was also assessed in streptozotocin-induced diabetic rats. Nanocrystals TD-A and TD-B showed 19.86 and 25.67-fold increase in saturation solubility, respectively, when compared with pure repaglinide. Almost 10 (TD-A) and 15 (TD-B)-fold enhancement in the oral bioavailability of nanocrystals was observed regardless of the fasted/fed state compared to pure repaglinide. Nanocrystal formulations also demonstrated significant (p<0.001) hypoglycemic activity with faster onset (less than 30 min) and prolonged duration (up to 8 h) compared to pure repaglinide (after 60 min; up to 4 h, respectively).

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Effect of ultrasound on anti-solvent crystallization process

Cited by 192 publications

References 14 publications

Antisolvent Crystallization of Poorly Water Soluble Drugs

Antisolvent Crystallization of Poorly Water Soluble Drugs

Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization

Ultra Rapidly Dissolving Repaglinide Nanosized Crystals Prepared via Bottom-Up and Top-Down Approach: Influence of Food on Pharmacokinetics Behavior

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