Effect of Ultrasound-Guided Quadratus Lumborum Block Preemptive Analgesia on Postoperative Recovery of Patients with Open Radical Colon Cancer Surgery: A Retrospective Study

Abstract

Purpose: To evaluate the effect of ultrasound-guided quadratus lumborum block (QLB) preemptive analgesia on recovery in colon cancer patients undergoing open radical surgery and provide reference for its clinical application. Methods: From July 2019 to June 2020, according to the anesthesia method, 56 patients who received open radical colon surgery were divided into two groups: Group Q (n=27), which received QLB combined general anesthesia, and Group C (n=29), which received general anesthesia only. Both groups were given self-controlled intravenous analgesia pump after surgery. The primary outcome is a series of parameters representing postoperative recovery. The secondary outcome was VAS scores and opioid consumption. Results: The first time of getting up, flatus, taking semi-liquid diet and the postoperative hospital stay in Group Q were significantly reduced (P<0.01). The rest and active VAS scores were significantly lower in Group Q (P<0.01). The opioids consumption was significantly decreased in Group Q (P<0.05). Conclusion:The application of ultrasound-guided QLB preemptive analgesia in open radical colon cancer surgery can significantly enhance the postoperative analgesia effect, reduce opioid consumption, and accelerate the postoperative recovery of the patients. Clinical Trial Registration Number:The Chinese Clinical Trial Registry (ChiCTR-2000034824).

Ultrasound-Guided Quadratus Lumborum Block Combined with General Anaesthesia or General Anaesthesia Alone for Laparoscopic Radical Gastrectomy for Gastric Adenocarcinoma: A Monocentric Retrospective Study

“…The sufentanil consumption during operation and after operation of Group QG was remarkably less than in Group GA (P<0.01). This also indicated that QLB combined with GA could significantly decrease perioperative pain, which was in line with the findings of Nie et al 29 and Zhu et al 30 who found that QLB distinctively lowered perioperative opioid consumption. In addition, several randomized controlled trial also reported that QLB appeared to decrease the need for opioid requirement for laparoscopic hepatectomy, laparoscopic colorectal surgery and laparoscopic nephrectomy.…”

“…Early postoperative recovery is affected by many factors, for example, degree of surgical trauma, post-surgical pain, postoperative activities, the first time of flatus and the postoperative hospitalization. 30,36 Our findings demonstrated that these indicators (The first time of postoperative ambulation, the first time of flatus and postoperative hospitalization) were evidently shorter in Group QG by comparison to those in Group GA (P<0.01). Our findings were similar to those of Wang et al 31 study which reported that QLB shortened the time of the first time of ambulation and anal flatus by comparison with Control group in laparoscopic radical gastrectomy surgery.…”

“…Our findings were similar to those of Wang et al 31 study which reported that QLB shortened the time of the first time of ambulation and anal flatus by comparison with Control group in laparoscopic radical gastrectomy surgery. A randomized trial by Nie et al 28 reported that QLB could markedly shorten the first time of postoperative movement and flatus, as well as postoperative hospital stay for laparoscopic radical gastrectomy in contrast to GA. Another randomized study by Wang et al 30 shown that QLB could significantly shortened the first time of movement, exhaust, taking semi-liquid food, and postoperative length of stay in open radical colon cancer surgery. More intriguingly, a latest randomized controlled trial by Zhu et al 29 revealed QLB could accelerate recovery, maintain independent cellular immune.…”

“…Moreover, it has lots of benefits such as effective analgesia, minimising opioid requirements, reduction side effect, suppressing inflammatory response and facilitating postoperative recovery. [28][29][30][31][32] However, to our knowledge, there is still lack of study comparing the surgical outcomes between ultrasound-guided QLB (UG-QLB) combined with GA and GA alone in laparoscopic radical gastrectomy for gastric adenocarcinoma. Therefore, in the monocentric retrospective research, we tested the primary hypothesis that UG-QLB combined with GA could improve recurrence-free survival (RFS) compared with GA alone in patients with gastric carcinoma undergoing laparoscopic radical gastrectomy.…”

Effects of Subcostal Anterior Quadratus Lumborum Block with and without Dexmedetomidine on Postoperative Rehabilitation in Patients Undergoing Laparoscopic Renal Surgery: A Prospective Double-Blinded Randomized Controlled Study

“…Likewise, other studies have reported that compared with GA, QLB for patients undergoing abdominal surgery shortened the first time of getting up, flatus and taking semi-liquid diet, findings consistent with our study. 13,45 Interestingly, Wu et al 25 found that ultrasound-guided deep serratus anterior plane block (dSAPB) combined with ropivacaine plus DEX might improve the QoR-15 in patients undergoing modified radical mastectomy. Nevertheless, there was no statistical difference between Groups DQG and QG.…”