Effect of two weeks' treatment with chlorimipramine and nortriptyline, alone or in combination with alcohol, on learning and memory

Liljequist, R.; Linnoila, Markku; Mattila, Mauri J.

doi:10.1007/bf00440847

Cited by 32 publications

(13 citation statements)

References 12 publications

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“…There are few studies investigating the effects of antidepressants on learning processes in healthy volunteers or healthy rats. Whereas most of them support the assumption, that antidepressants do not seem to impair learning in healthy subjects (Liljequist et al, 1974), some also report of inconclusive results (Jansen and Andrews, 1994).…”

Section: Discussionmentioning

confidence: 96%

Distance from source of reward as a marker for extinction-induced “despair”: Modulation by the antidepressants clomipramine and citalopram

et al. 2012

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Section: Discussionmentioning

confidence: 96%

Distance from source of reward as a marker for extinction-induced “despair”: Modulation by the antidepressants clomipramine and citalopram

et al. 2012

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“…For each testing session an alternate form of the material was prepared. The syllables were CVC syllables (Hilgard, 1951), sensitive to drug effects (Liljequist et al, 1974;McNair, 1973), and standardized for the Finnish speaking population. The learning capacity was assigned from the number of errors and repetitions.…”

Section: Assessment Of Memory Effectsmentioning

confidence: 99%

Effects on Learning and Memory of 2-Week Treatments with Chlordiazepoxide Lactam, N-Desmethyldiazepam, Oxazepam and Methyloxazepam, Alone or in Combination with Alcohol

Liljequist¹,

Palva²,

Linnoila³

1979

Int Pharmacopsychiatry

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A aouble-blind study with 40 healthy students was done in order to measure the effects of a 2-week treatment with chlordiazepoxide lactam (5 mg), nordiazepam (10 mg), oxazepam (15 mg) and methyloxazepam (20 mg) on immediate memory and associative learning. The drugs were administered t.i.d. and the tests were done after the very last capsule was given. It was ingested with a placebo drink and 0.5 g alcohol/kg body weight. Oxazepam and methyloxazepam alone behaved similar to the placebo. Immediate memory was significantly impaired following the treatment with nordiazepam, chlordiazepoxide lactam, alcohol, and after the simultaneous administration of nordiazepam and chlordiazepoxide lactam with alcohol. Chlordiazepoxide lactam was the only drug which alone impaired associative learning. Also alcohol alone, and all the drugs in combination with alcohol retarded learning acquisition.

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“…In contrast, amitriptyline reduces the turnover of both noradrenaline and serotonin by inhibiting the re-uptake of these amines (Kafoe & Leonard, 1973 Nortriptyline, which is structurally related to amitriptyline, caused significant but weaker impairment than amitriptyline under similar experimental conditions. Chlorimipramine and mianserin behaved in a similar manner, except that a slight alcoholantagonizing effect was found with chlorimipramine which in a 2-week study showed a strong action to adrenergic nerve function (Liljequist et al, 1974). Therefore, the interpretation done in that study, i.e.…”

Section: Discussionmentioning

confidence: 52%

“…Previous results from this laboratory (Liljequist, Linnoila & Mattila, 1974) indicate that low therapeutic doses of nortriptyline, given three times a day to healthy human subjects, impaired learning, probably by interfering with the acquisition processes. In these conditions another tricyclic antidepressant chlorimipramine, proved ineffective and even antagonized the alcohol-induced impairment.…”

Section: Introductionmentioning

confidence: 80%

Amitriptyline‐ and mianserin‐induced changes in acquisition of paired‐ association learning‐task.

Liljequist¹,

Seppαlä²,

Mattila³

1978

Brit J Clinical Pharma

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I The double-blind study on twenty healthy students was an attempt at assessing the effects of 2-week's treatment with amitriptyline (25 mg three times a day) and mianserin (10 mg three times a day), each alone or separatively inbibed with alcohol (0.5 g/kg) on the immediate memory and on the acquisition of a paired-association learning-task. 2 Amitriptyline impaired both the short-term memory-span and acquisition, and alcohol potentiated these effects. The action of mianserin did not deviate significantly from that of the placebo, and it also failed to interact with alcohol. 3 It is concluded that the decrement in learning capacity, that occurs after the 2-week's treatment with therapeutic doses of amitriptyline, reflects changes in both the intrinsic and the regulatory mechanisms of learning.

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Effect of two weeks' treatment with chlorimipramine and nortriptyline, alone or in combination with alcohol, on learning and memory

Cited by 32 publications

References 12 publications

Distance from source of reward as a marker for extinction-induced “despair”: Modulation by the antidepressants clomipramine and citalopram

Distance from source of reward as a marker for extinction-induced “despair”: Modulation by the antidepressants clomipramine and citalopram

Effects on Learning and Memory of 2-Week Treatments with Chlordiazepoxide Lactam, N-Desmethyldiazepam, Oxazepam and Methyloxazepam, Alone or in Combination with Alcohol

Amitriptyline‐ and mianserin‐induced changes in acquisition of paired‐ association learning‐task.

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