Effect of Two Weeks of rTMS on Brain Activity in Healthy Subjects During an n-Back Task: A Randomized Double Blind Study

Gaudeau-Bosma, Christian; Moulier, Virginie; Allard, Anne-Camille; Sidhoumi, D.; Bouaziz, Noomane; Braha, S.; Volle, Emmanuelle; Januel, Dominique

doi:10.1016/j.brs.2012.10.009

Cited by 40 publications

(27 citation statements)

References 53 publications

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“…Regarding blinding, half of the studies were double-blinded (Barr et al, 2013;Gaudeau-Bosma et al, 2012;Guse et al, 2013;Keeser et al, 2013;Oliveira et al, 2013;Teo et al, 2011) and the other half were double single-blinded, i.e., the subject and the evaluator were blinded to the allocation group, but not the person applying the stimulation. The time period between stimulation conditions ranged from at least one hour to more than one week (Mulquiney, Hoy, Daskalakis, & Fitzgerald, 2011).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…We also identified a non-significant between study heterogeneity (I 2 =0%, p=0.83). Funnel plot visualization (Supplementary Figure 4) and sensitivity analysis revealed respectively that the risk of publication was low and that no study particularly influenced the net results, which ranged from --0.26 to -0.3 after excluding experiments of Gaudeau-Bosma et al (2012) and Keeser et al (2013). (Figure 3) …”

Section: Percentage Of Error Responsesmentioning

confidence: 99%

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Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Brunoni

Vanderhasselt

2014

Brain and Cognition

543

411

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Recent studies have used non-invasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), to increase dorsolateral prefrontal cortex (DLPFC) activity and, consequently, working memory (WM) performance.. However, such experiments have yielded mixed results, possibly due to small sample sizes and heterogeneity of outcomes. Therefore, our aim was to perform a systematic review and metaanalyses on NIBS studies assessing the n-back task, which is a reliable index for WM. From the first data available to February 2013, we looked for sham-controlled, randomized studies that used NIBS over the DLPFC using the n-back task in PubMed/MEDLINE and other databases. Twelve studies (describing 33 experiments) matched our eligibility criteria. Active vs. sham NIBS was significantly associated with faster response times (RT), higher percentage of correct responses and lower percentage of error responses. However, meta-regressions showed that tDCS (vs. rTMS) presented an improvement only in RT. This could have occurred in part because almost all tDCS studies employed a crossover design (possibly more employed in tDCS over rTMS due to the reliable tDCS blinding) -this factor (study design) was also associated with no improvement in correct responses in the active vs. sham groups. To conclude, rTMS over the DLPFC significantly improved all measures of WM performance whereas tDCS significantly improved RT, but not the percentage of correct and error responses. Mechanistic insights on the role of DLPFC in WM are further discussed, as well as how NIBS techniques could be used in neuropsychiatric samples presenting WM deficits, such as major depression, dementia and schizophrenia.

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Section: Quality Assessmentmentioning

confidence: 99%

Section: Percentage Of Error Responsesmentioning

confidence: 99%

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Brunoni

Vanderhasselt

2014

Brain and Cognition

543

411

View full text Add to dashboard Cite

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“…Administration time was approximately 10 min. (Beam et al 2009), with the coil positioned tangential to the scalp with the handle pointing back and away from the midline at 45° (as in Gaudeau-Bosma et al 2013). We used a high-frequency repetitive TMS protocol at 10 Hz stimulation, known to induce facilitation effects in motor cortex (Pascual-Leone et al 1998;Maeda et al 2000).…”

Section: Stockings Of Cambridge Task (Soc)mentioning

confidence: 99%

“…Relatively few studies to date have demonstrated such effects (Preston et al 2010;Esslinger et al 2014;Hoy et al 2015), with others finding no significant effects (Gaudeau-Bosma et al 2013;Guse et al 2013). Given the large variability in cognitive tasks, stimulation protocols, and targeted cortical sites in these studies, the effectiveness of TMS in enhancing WM remains an open question.…”

mentioning

confidence: 99%

“…For example, motor cortex appears to be less excitable following stimulation at lower rTMS frequencies, in the 1 Hz range, and more excitable following stimulation by 10 Hz trains (Pascual-Leone and Hallett 1994). The lasting modulatory effects of rTMS have been extensively demonstrated (Maeda et al 2000;Tegenthoff et al 2005;Fregni and Pascual-Leone 2007;Brunoni and Vanderhasselt 2014) and make it a suitable methodological choice for WM enhancement studies (Esslinger et al 2014;Brunoni & Vanderhasselt 2014;Gaudeau-Bosma et al 2013;Guse et al 2013).…”

mentioning

confidence: 99%

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Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

et al. 2016

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The effect of high-frequency rTMS over left DLPFC and fluid abilities on goal neglect

Arabacı,

Cakir,

Parris

2024

Brain Struct Funct

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Goal neglect refers to when an aspect of task instructions is not utilised due to increased competition between goal representations, an attentional limit theoretically linked to working memory. In an attempt to alleviate goal neglect and to investigate the association between dorsolateral prefrontal cortex (DLPFC)-supported working memory and goal neglect, we used high-frequency repetitive transcranial magnetic stimulation to the left DLPFC whilst participants completed the letter-monitoring task, a measure of goal neglect, and an N3-back task, a working memory task known to be affected by rTMS of the left DLPFC, following 20 min of active and sham stimulation (run on separate days). We found increased accuracy on the N3-back task in addition to decreased goal neglect in the active compared to sham condition when controlling for age and fluid abilities (as assessed by matrix reasoning performance). Furthermore, analysis showed that active stimulation improvements on both the N3-back and letter-monitoring tasks were greater for those with higher fluid abilities. These findings provide support for the link between the DLPFC-support working memory and goal neglect. Increased performance on the N3-back task also supports the literature reporting a link between left DLPFC and verbal working memory. Results are evaluated in the context of potential use to alleviate symptoms of disorders related to goal neglect.

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Effect of Two Weeks of rTMS on Brain Activity in Healthy Subjects During an n-Back Task: A Randomized Double Blind Study

Cited by 40 publications

References 53 publications

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

The effect of high-frequency rTMS over left DLPFC and fluid abilities on goal neglect

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