Effect of two treatment protocols for ketosis on the resolution, postpartum health, milk yield, and reproductive outcomes of dairy cows

Jeong, Jae-Kwan; Choi, In‐Soo; Moon, Sungho; Lee, Soo-Chan; Kang, Hyun‐Gu; Jung, Young-Hun; Park, Soo-Bong; Kim, Ill-Hwa

doi:10.1016/j.theriogenology.2017.09.030

Cited by 17 publications

(20 citation statements)

References 53 publications

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“…The rumen fill score and body condition score (BCS) are also direct tools to evaluate the feed intake and energy balance status. The PG treatment improved the rumen fill score and lowed BCS loss in the dairy cows, which were diagnosed with ketosis in the results of Jeong et al [61]. The increasing DMI and rumen fill scores are beneficial for decreasing the adverse impact of NEB.…”

Section: The Effects Of Pg On Dmi and Rumen Fermentationmentioning

confidence: 90%

“…The addition of dexamethasone [18] and glycerol [49] to PG showed no additional benefits and the fat appeared to blunt the metabolic response to PG administration of cows [13]. The combination of butaphosphan-cyanocobalamin [80], glucocorticoids [83], L-carnitine-methionine [61], and glucose [84] with PG to the cows of hyperketonemia are beneficial in improving the chances of the resolution of ketosis compared to PG only.…”

Section: The Research Of Combination Therapymentioning

confidence: 99%

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Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Zhang

Nan

Wang

et al. 2020

Animals

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With the improvement in the intense genetic selection of dairy cows, advanced management strategies, and improved feed quality and disease control, milk production level has been greatly improved. However, the negative energy balance (NEB) is increasingly serious at the postpartum stage because the intake of nutrients cannot meet the demand of quickly improved milk production. The NEB leads to a large amount of body fat mobilization and consequently the elevated production of ketones, which causes metabolic diseases such as ketosis and fatty liver. The high milk production of dairy cows in early lactation aggravates NEB. The metabolic diseases lead to metabolic disorders, a decrease in reproductive performance, and lactation performance decline, seriously affecting the health and production of cows. Propylene glycol (PG) can alleviate NEB through gluconeogenesis and inhibit the synthesis of ketone bodies. In addition, PG improves milk yield, reproduction, and immune performance by improving plasma glucose and liver function in ketosis cows, and reduces milk fat percentage. However, a large dose of PG (above 500 g/d) has toxic and side effects in cows. The feeding method used was an oral drench. The combination of PG with some other additives can improve the effects in preventing ketosis. Overall, the present review summarizes the recent research progress in the impacts of NEB in dairy cows and the properties of PG in alleviating NEB and reducing the risk of ketosis.

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Section: The Effects Of Pg On Dmi and Rumen Fermentationmentioning

confidence: 90%

Section: The Research Of Combination Therapymentioning

confidence: 99%

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Zhang

Nan

Wang

et al. 2020

Animals

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“…7 Subclinical ketosis therefore causes huge economic loss in the dairy industry. Drugs used currently to treat simple ketosis include glucose (GLu), 8 propylene glycol, 9 and glycerin. 10 These drugs have played an important role in the treatment of ketosis either because of the direct supplementation of GLu or the stimulation of gluconeogenesis.…”

Section: Introductionmentioning

confidence: 99%

Metabolic alterations in dairy cows with subclinical ketosis after treatment with carboxymethyl chitosan‐loaded, reduced glutathione nanoparticles

Bai

et al. 2020

Veterinary Internal Medicne

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Background: Subclinical ketosis (SCK) causes economic losses in the dairy industry because it reduces the milk production and reproductive performance of cows. Hypothesis/Objectives: To evaluate whether carboxymethyl chitosan-loaded reduced glutathione (CMC-rGSH) nanoparticles can alleviate the incidence or degree of SCK in a herd. Animals: Holstein dairy cows 21 days postpartum (n = 15). Methods: The trial uses a prospective study. Five cows with serum β-hydroxybutyric acid (BHBA) ≥1.20 mmol/L and aspartate aminotransferase (AST) <100 IU/L were assigned to group T1, 5 cows with BHBA ≥1.20 mmol/L and AST >100 IU/L to group T2, and 5 cows with BHBA <1.00 mmol/L and AST <100 IU/L to group C. Carboxymethyl chitosan-loaded reduced glutathione (0.012 mg/kg body weight per cow) was administered to cows in T1 and T2 once daily via jugular vein for 6 days after diagnosis. Serum from all groups were collected 1 day before administration, then on days 1, 3, 5, 7, 10, and 15 after administration to determine the changes in biochemical index and 1 H-NMR.

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“…Subclinical ketosis (SK) is a common metabolic disorder of transition dairy cows during the early lactation period (Kaya et al, 2016;Zhang et al, 2016). The development of ketosis is associated with malfunction in the regulation of energy metabolism with excessive negative energy balance for long periods of time (Shin et al, 2015;Jeong et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Association of Prepartum Hypoleptinemia and Postpartum Subclinical Ketosis in Holstein Dairy Cows

He¹

2018

PVJ

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Effect of two treatment protocols for ketosis on the resolution, postpartum health, milk yield, and reproductive outcomes of dairy cows

Cited by 17 publications

References 53 publications

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Metabolic alterations in dairy cows with subclinical ketosis after treatment with carboxymethyl chitosan‐loaded, reduced glutathione nanoparticles

Association of Prepartum Hypoleptinemia and Postpartum Subclinical Ketosis in Holstein Dairy Cows

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