Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator‐blind, placebo‐controlled, 3‐week experimental gingivitis study

Lorenz, K.; Bruhn, G; Heumann, Christian; Netuschil, L; Brecx, M; Hoffmann, Thomas

doi:10.1111/j.1600-051x.2006.00946.x

Cited by 69 publications

(80 citation statements)

References 34 publications

(38 reference statements)

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“…Chlorhexidine (CHX) is one of the most effective antimicrobial agents for plaque control. [5][6][7][8][9][10] It is retained in the oral cavity and is progressively desorbed in bacteriostatic concentrations 8 hours after rinsing.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the effect of two chlorhexidine mouthrinses on plaque accumulation and gingival bleeding

Neto¹,

Parolo²,

Rösing

et al. 2008

Braz. oral res.

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The aim of the present study was to evaluate the effect of two chlorhexidine rinsing solutions (0.12% and 0.2%) on plaque and gingival bleeding. Ten dental students participated in this double-blind, cross-over study, rinsing twice a day, for one minute, with each one of the tested solutions for fourteen days. A wash-out period of one week between treatments was observed. In order to assess gingival bleeding, the van der Weijden et al. 1 (1994) index was used. The plaque indexes used were those of Quigley, Hein 2 (1962) and Silness, Löe 3 (1964). In the pre-experimental period, subjects received oral hygiene instructions and dental prophylaxis. The results revealed no significant differences between both concentrations in relation to plaque and gingival bleeding. Mean values (± standard deviation) of the Quigley & Hein index were 0.25 ± 0.16 for the 0.12% solution and 0.23 ± 0.26 for the 0.2% solution (p = 0.4838). Mean values (± standard deviation) of the Silness-Löe index were 0.12 ± 0.10 for the 0.12% solution and 0.11 ± 0.11 for the 0.2% solution (p = 0.7592). The bleeding index mean values at the end of the study were not different for both concentrations with mean values (± standard deviation) of 14.93% ± 6.68% and 13.95 ± 9.24% for the 0.12% and 0.2% solutions, respectively. Although an increase in gingival bleeding was observed, both concentrations were able to control dental plaque.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of the effect of two chlorhexidine mouthrinses on plaque accumulation and gingival bleeding

Neto¹,

Parolo²,

Rösing

et al. 2008

Braz. oral res.

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“…In the absence of mechanical oral hygiene procedures, the 6-day (short-term) plaque re-growth study is conducted. Similarly, in several studies, a short-term plaque regrowth model was used to assess the chemotherapeutic plaque inhibitory activity of different formulations (1,8,9,13,18).…”

Section: Discussionmentioning

confidence: 99%

“…The experimental gingivitis and dental plaque accumulation models are acknowledged as the best design to prove both plaque accumulation and gingival health effects of active components in mouthrinse preparations, as shown in numerous clinical studies (13,18,19).…”

Section: Discussionmentioning

confidence: 99%

“…All subjects were given the same toothpaste and toothbrush (Colgate-Palmolive Company, USA) (13). Neither the subjects nor the examiners knew which formulation was assigned to a subject.…”

Section: Groupmentioning

confidence: 99%

“…Following clinical indices (at baseline and after the rinse phase of the study, Day-0 and Day-6), data were recorded for monitoring the plaque accumulation and gingival situation of the participants before and after the rinse phase of the study: Turesky Modification of Quigley-Hein Plaque Index (TMQHP) with the use of a 0.2 % erythrosine disclosing agent and gingival index (GI) (13). All clinical parameters were measured with a William's probe calibrated in millimeters.…”

Section: Investigated Parametersmentioning

confidence: 99%

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A Comparative Study of Fluoride Containing Chlorhexidine and Non-Chlorhexidine Mouthrinses in a Teenage Group

et al. 2012

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Aim: The study was planned to assess the effect of a mouthrinse containing Chlorhexidine (CHX) and amine/stannous fluoride (AmF) on plaque accumulation, gingivitis and salivary fluoride levels in comparison with two mouthrinses containing either essential oils (EO) or cetylpyridinium chloride (CPC) with sodium fluoride (NaF) in a teenage group. Methodology: For this study 82 healthy teenage between 13 and 16 years were recruited for participation. The experimental gingivitis model consisted of a 2-weeks recruitment phase, followed by a 6-day rinsing period with one of the 4 mouthrinse formulations was used for the study. At the end of the pre-phase period and the rinsing period (Day-0/Day-6), gingival index (GI), plaque index (PI) and salivary fluoride levels were recorded. The statistical analyses were performed using Wilcoxon sign test and the dependent t test.

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Effect of Terminalia chebula Extract and Chlorhexidine on Salivary pH and Periodontal Health: 2 Weeks Randomized Control Trial

Gupta

Bhaskar

Gupta³

et al. 2013

Phytotherapy Research

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A double blind, randomized, controlled study with three parallel treatment groups was done to evaluate the efficacy of a Terminalia chebula 10% mouth rinse compared with chlorhexidine 0.12% mouth rinse, applied two times daily for 2 weeks, in the treatment of dental plaque and gingivitis. Seventy‐eight patients were included in the study. The efficacy variables were periodontal indices on days 0, 7 and 14 after commencement of therapy. Twenty six patients received chlorhexidine mouth rinse, twenty six Terminalia chebula mouth rinse and twenty six received saline solution. The clinical parameters were significantly reduced by both chlorhexidine and Terminalia chebula mouth rinse although no significant difference was seen between the two groups (P > 0.05). This study demonstrated that Terminalia chebula mouth rinse is effective in reducing microbial plaque, gingival inflammation and neutralizing salivary pH. Copyright © 2013 John Wiley & Sons, Ltd.

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Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator‐blind, placebo‐controlled, 3‐week experimental gingivitis study

Abstract: The two new CHX mouthrinses were able to inhibit plaque re-growth and gingivitis. Neither the omission of alcohol nor the supplementation with sodium fluoride had weakened the clinical efficacy of CHX with respect to the analysed clinical parameters.

Cited by 69 publications

References 34 publications

Comparative analysis of the effect of two chlorhexidine mouthrinses on plaque accumulation and gingival bleeding

Comparative analysis of the effect of two chlorhexidine mouthrinses on plaque accumulation and gingival bleeding

A Comparative Study of Fluoride Containing Chlorhexidine and Non-Chlorhexidine Mouthrinses in a Teenage Group

Effect of Terminalia chebula Extract and Chlorhexidine on Salivary pH and Periodontal Health: 2 Weeks Randomized Control Trial

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