Effect of Two Furanocoumarins and Three Other Coumarins on Ultrastructure, ATPases and Acid Phosphatases in Meristematic Cells of Allium cepa Root Tips

Podbielkowska, Maria; Wałęza, Maria; Dobrzyńska, Katarzyna; Zobel, Alicja M.

doi:10.1076/phbi.34.2.96.13194

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…The growth regulating activity of COU and/or its derivatives were investigated using root tips of onion (Podbielkowska et al, 1996), sunflower hypocotyl and wheat coleoptile segments (Alexieva et al, 1995;Neumann, 1959), stem cuttings (Tartoura et al, 2004), different primary root zones of maize (Lupini et al, 2010) and intact plants such as Arabidopsis, pea, wheat, cucumber, soybean and faba bean (Alexieva et al, 1995;Lupini et al, 2014;Stanchev et al, 2010). Some investigations suggest that COU may have an auxin-like behavior, on initiation of adventitious roots, and/or interfere with the auxin signaling pathways (Abenavoli et al, 2001;Lupini et al, 2010;Neumann, 1959;Tartoura et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Evidence for “gibberellin-like” activity of coumarin

Saleh

El-Soud

2015

South African Journal of Botany

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The existing body of information defines some regulatory functions to secondary metabolites like coumarin (COU). Experience and some experimental results in our laboratory tempted us to test a GA-like activity of COU. Experiments were conducted with endospermic (de-embryonated) and embryonic wheat half grains treated with different concentrations of COU, for different time courses, alone or in combination with the GAbiosynthesis inhibitor paclobutrazol (P). Results showed that treatment with COU caused stimulation of amylase synthesis and secretion from aleurone layer cells. P did not affect synthesis but slightly reduced excretion of amylase. However, germination percentage of intact wheat grains and seedling growth were inhibited by COU in a concentration-dependent manner. This indicates that COU has some GA-like effect, and also affects other aspects of germination and seedling establishment. This GA-like effect was also confirmed by the observed increase in elongation of wheat seedlings second leaf sheath and pea stem when treated with COU. These potential regulatory roles of COU may indicate that secondary metabolites have more important roles during different plant developmental processes.

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Section: Introductionmentioning

confidence: 99%

Evidence for “gibberellin-like” activity of coumarin

Saleh

El-Soud

2015

South African Journal of Botany

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“…The results showed that 4-Me-7-Ph-C increased perfusion pressure over time compared to vehicle; this phenomenon could be achieved by producing changes in some biological systems. This hypothesis and earlier findings indicate that some coumarin derivatives can produce changes in the biological activity of the ATPase enzyme [32]. For this reason, we determined the effect of 4-Me-7-Ph-C in the presence or absence of ouabain (ATPase inhibitor) on left ventricular pressure.…”

Section: Discussionmentioning

confidence: 90%

Biological Activity of a Coumarin Derivative on Heart Failure Using an Ischemia/Reperfusion Injury Model

Figueroa-Valverde,

Rosas-Nexticapa,

Alvarez-Ramirez

et al. 2024

Drug Res (Stuttg)

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Heart failure is a health problem worldwide. There are some drugs for it, including digoxin, spironolactone, captopril, and valsartan, but some of these drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia, hyponatremia and hypotension. The aim of this research was to evaluate the biological activity of coumarin (2H-chromen-2-one) and its derivatives (3BrAcet-C, 3–4Br-Ph-C, 4-CN-7D-C, 4-Me-7-Ph-C and 6Br-3-D-C) against ischemia/reperfusion injury as a therapeutic alternative for heart failure. In addition, the biological activity of the coumarin derivative 4-Me-7-Ph-C on left ventricular pressure (LVP) was determined in the absence or presence of ouabain and nifedipine at a dose of 1 nM using an isolated rat heart model. The results showed that i) the coumarin derivative 4-Me-7-Ph-C significantly decreased the infarct area (p+=+0.05) compared with 3BrAcet-C, 3–4Br-Ph-C, 4-CN-7D-C, and 6Br-3-D-C; and ii) 4-Me-7-Ph-C increased LVP in a dose-dependent manner, which effect was inhibited by nifedipine. These data suggest that coumarin 4-Me-7-Ph-C may act as a type-L calcium channel activator, so it could be a good agent to treat heart failure.

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“…Conversely, although not comparable with the present experiments, Podbiekowska et al . () recorded a coumarin‐induced inhibitory effect of H + ‐ATPase activity in onion. Furthermore, negative effects on PM H + ‐ATPase activity caused by several allelochemicals, such as trans ‐cinnamic acid and some derivatives (Abenavoli et al .…”

Section: Discussionmentioning

confidence: 99%

Coumarin enhances nitrate uptake in maize roots through modulation of plasma membrane H⁺‐ATPase activity

et al. 2017

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Coumarin is one of the simplest plant secondary metabolites, widely distributed in the plant kingdom, affecting root form and function, including anatomy, morphology and nutrient uptake. Although, some plant responses to coumarin have been described, comprehensive knowledge of the physiological and molecular mechanisms is lacking. Maize seedlings exposed to different coumarin concentrations, alone or in combination with 200 μm nitrate (NO ), were analysed, through a physiological and molecular approach, to elucidate action of coumarin on net NO uptake rate (NNUR). In detail, the time course of NNUR, plasma membrane (PM) H -ATPase activity, proton pumping and related gene expression (ZmNPF6.3, ZmNRT2.1, ZmNAR2.1, ZmHA3 and ZmHA4) were evaluated. Coumarin alone did not affect nitrate uptake, PM H -ATPase activity or transcript levels of ZmNRT2.1 and ZmHA3. In contrast, coumarin alone increased ZmNPF6.3, ZmNAR2.1 and ZmHA4 expression in response to abiotic stress. When coumarin and NO were concurrently added to the nutrient solution, a significant increase in the NNUR, PM H -ATPase activity, together with ZmNAR2.1:ZmNRT2.1 and ZmHA4 expression was observed, suggesting that coumarin affected the inducible component of the high affinity transport system (iHATS), and this effect appeared to be mediated by nitrate. Moreover, results with vanadate, an inhibitor of the PM H -ATPase, suggested that this enzyme could be the main target of coumarin. Surprisingly, coumarin did not affect PM H -ATPase activity by direct contact with plasma membrane vesicles isolated from maize roots, indicating its possible elicitor role in gene transcription.

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Effect of Two Furanocoumarins and Three Other Coumarins on Ultrastructure, ATPases and Acid Phosphatases in Meristematic Cells of Allium cepa Root Tips

Cited by 6 publications

References 22 publications

Evidence for “gibberellin-like” activity of coumarin

Evidence for “gibberellin-like” activity of coumarin

Biological Activity of a Coumarin Derivative on Heart Failure Using an Ischemia/Reperfusion Injury Model

Coumarin enhances nitrate uptake in maize roots through modulation of plasma membrane H⁺‐ATPase activity

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Effect of Two Furanocoumarins and Three Other Coumarins on Ultrastructure, ATPases and Acid Phosphatases in Meristematic Cells of Allium cepa Root Tips

Cited by 6 publications

References 22 publications

Evidence for “gibberellin-like” activity of coumarin

Evidence for “gibberellin-like” activity of coumarin

Biological Activity of a Coumarin Derivative on Heart Failure Using an Ischemia/Reperfusion Injury Model

Coumarin enhances nitrate uptake in maize roots through modulation of plasma membrane H+‐ATPase activity

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Coumarin enhances nitrate uptake in maize roots through modulation of plasma membrane H⁺‐ATPase activity