1986
DOI: 10.1007/bf00613512
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Effect of two different doses of nitrendipine on steady-state plasma digoxin level and systolic time intervals

Abstract: The effect of two different doses of nitrendipine on plasma digoxin levels, urinary recovery and systolic time intervals was investigated in 8 healthy volunteers. Following a loading dose, digoxin 0.25 mg b.d.p.o. was given alone for 2 weeks. Then 0.25 mg digoxin b.d. was administered for two 1-week periods combined with nitrendipine 10 mg or 20 mg once daily. The study was completed with another digoxin monotherapy phase lasting 7 days. Nitrendipine 20 mg daily led to a significant increase in plasma digoxin … Show more

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Cited by 12 publications
(3 citation statements)
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“…Finally, nitridipine fails to block either digitoxin channels or digitoxin-mediated calcium entry into cells. This failure also is paralleled by clinical experience (4). Although other entry mechanisms cannot be excluded, these data together constitute strong evidence that intrinsic calcium channel activity constitutes a biologically important, calcium-dependent toxicity mechanism for digitoxin and other clinically important cardiac glycosides.…”
Section: Discussionmentioning
confidence: 78%
See 1 more Smart Citation
“…Finally, nitridipine fails to block either digitoxin channels or digitoxin-mediated calcium entry into cells. This failure also is paralleled by clinical experience (4). Although other entry mechanisms cannot be excluded, these data together constitute strong evidence that intrinsic calcium channel activity constitutes a biologically important, calcium-dependent toxicity mechanism for digitoxin and other clinically important cardiac glycosides.…”
Section: Discussionmentioning
confidence: 78%
“…A consequence of this slight depolarization process is that voltagedependent calcium channels may open, thereby permitting calcium entry into the cell. However, this reasoning has been challenged by the fact that nitrendipine, a classical voltage-dependent calcium channel blocker, fails to reverse cardiac glycoside-induced side effects in healthy human volunteers (4). An alternative mechanism has been a slight increase in intracellular Na, followed by exchange for extracellular Ca 2ϩ by the NCX sodium/calcium exchanger (5).…”
mentioning
confidence: 99%
“…According to Kirch et al, [82] nitrendipine 20mg daily, but not 10mg daily, caused a significant increase in the plasma concentrations and AUC of digoxin, which would rarely be of clinical relevance. However, in this study 1 patient out of 8 withdrew from the study because of adverse reactions, including nausea and dizziness, showing that the interaction between nitrendipine and digoxin may be of clinical relevance in certain patients.…”
Section: Nifrendipinementioning
confidence: 99%