Effect of two different delivery systems of honey on the healing of oral ulcer in an animal model

Abstract

Honey had several healing properties which includes antibacterial, anti-inflammatory and antioxidant properties. Hence, the aim of this study was to evaluate the effect of two different systems of honey on the healing of experimentally created traumatic oral ulcers in rats. Traumatic ulcers were created on the lower labial mucosa on male rats using 50% acetic acid. The rats were subsequently divided into three groups; in group one and two, the ulcers were treated with honey gel and honey adhesive respectively, whereas the third group received no treatment. The ulcers were macroscopically and microscopically studied. A statistical significant difference was observed in macroscopic investigation among the three groups in the 3rd and 7th day (p \ 0.05). However, there were no statistical significant findings by the 15th day although a complete clinical healing was virtually observed in most of the cases. Histological examination shows a statistical significant difference within each of the three groups over time (p \ 0.05). On the other hand, the mean rank values for the honey gel group were significantly higher in comparison to the other groups over time (p \ 0.05). The therapeutic value of honey gel appears to be more effective than the mucoadhesive form in shortening the duration of wound healing.

Studies of efficacy of Achillea species ethanol extract and honey on full thickness wound healing in diabetic albino rats

“…Both honey and Achillea were previously reported to possess wound healing promotion effects based on their effective antioxidant properties. Honey was tried with effective results in promoting healing of oral ulcer in experimental animal models 30 and clinical trials 2 .The effects of most types of honeys used were mostly related to their antimicrobial and antioxidant properties 31 . As was documented by Dons and Soosairaj 32 who reported that honey enhanced wound healing by stimulated tissue growth, enhanced epithelial growth and reduced scar formation, and this was because honey is acidic, containing hydrogen peroxide, nutrients and antioxidants, and enhanced immunity.…”

Honey Composition, Therapeutic Potential and Authentication through Novel Technologies: An Overview

“…Although there was complete healing in both of the groups, microscopically a significant difference was observed, with the gel having a higher mean value. So, it could be concluded that the therapeutic value of gel is more than that of the adhesive form in wound healing [37].…”

A call for action to the biomaterial community to tackle antimicrobial resistance

“…Despite the water sensitivity of ROS producing honey biomaterial scientists have pushed forward the development of novel strategies to increase the presence of this type of honey in wound care. Research by Febriyenti et al 212 and Khounganian et al 213 explored formulating honey gels in order to ease delivery and stimulate wound healing. In both cases ROS producing honey gel shortened the wound healing time significantly and produced no negative side effects when compared with untreated and nondisclosed commercial products.…”