Effect of tumor necrosis factor-alpha on the permeability of bovine brain microvessel endothelial cell monolayers

Anda, Takeo; Yamashita, Hiromi; Khalid, Humayun; Tsutsumi, Keisuke; Fujita, H; Tokunaga, Yoshiharu; Shibata, Shôbu

doi:10.1080/01616412.1997.11758599

Cited by 41 publications

(22 citation statements)

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“…Both hepatic failure [34] and sepsis [25,26] are characterized by high levels of circulating cytokines. The results of experiments using cultures of bovine [35] and human [36] brain endothelium suggest that cytokines increase blood-brain barrier permeability. In our experiments, the intercellular tight junctions appeared intact.…”

Section: Discussionmentioning

confidence: 97%

Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex

Papadopoulos¹,

LAMB²,

Moss³

et al. 1999

Clinical Science

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Encephalopathy is a common complication of sepsis. However, little is known about the morphological changes that occur in the brain during sepsis. Faecal peritonitis was induced in pigs that were killed 8 h later and frontal cortex samples were taken immediately after death. The tissue was investigated using light and electron microscopy and compared with frontal cortex samples taken from sham-operated controls. Septic pigs had 49.5% more perimicrovessel oedema than sham pigs. However, the tight junctions between cerebral microvessel endothelial cells appeared morphologically intact in both septic and sham pigs. Sepsis also resulted in neuronal injury, disruption of astrocytic end-feet and swollen, rounded erythrocytes. These morphological changes may be sufficient to underlie the clinical features seen in septic encephalopathy.

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Section: Discussionmentioning

confidence: 97%

Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex

Papadopoulos¹,

LAMB²,

Moss³

et al. 1999

Clinical Science

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“…TNF-α selectively promoted the in vitro permeability of the blood-brain barrier to CDDP without disrupting tight junctions (45). So, CDDP can enter and cause neurotoxicity in the brain tissue in this way.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Antioxidant Caffeic Acid Phenethyl Ester (Cape) on Some Enzyme Activities in Cisplatin-Induced Neurotoxicity in Rats

et al. 2006

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“…Compromised barrier integrity was evidenced in animal model and human sepsis by monitoring the levels or transport of various markers in the brain parenchyma (Jeppsson et al, 1981;Siami et al, 2008). Various cytokines released by activated leukocytes were shown to induce increased pinocytosis by endothelial cells (Anda et al, 1997;Huynh and Dorovini-Zis, 1993) and recently a central role of complement components (C5a) in blood-brain barrier dysfunction in sepsis was shown (Flierl et al, 2009). Apparent diffusion coefficients measured in the cortex and thalamus of septic animals indicated alterations in this parameter, which were related to the outcome.…”

Section: Discussionmentioning

confidence: 99%

Sepsis-Associated Encephalopathy: A Magnetic Resonance Imaging and Spectroscopy Study

Bozza

Garteiser

Oliveira

et al. 2009

J Cereb Blood Flow Metab

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Brain dysfunction is frequently observed in sepsis as a consequence of changes in cerebral structure and metabolism, resulting in worse outcome and reduced life-quality of surviving patients. However, the mechanisms of sepsis-associated encephalopathy development and a better characterization of this syndrome in vivo are lacking. Here, we used magnetic resonance imaging (MRI) techniques to assess brain morphology and metabolism in a murine sepsis model (cecal ligation and puncture, CLP). Sham-operated and CLP mice were subjected to a complete MRI session at baseline, 6 and 24 h after surgery. Accumulation of vasogenic edematic fluid at the base of the brain was observed in T 2 -weighted image at 6 and 24 h after CLP. Also, the water apparent diffusion coefficients in both hippocampus and cortex were decreased, suggesting a cytotoxic edema in brains of nonsurvival septic animals. Moreover, the N-acetylaspartate/choline ratio was reduced in brains of septic mice, indicating neuronal damage. In conclusion, noninvasive assessment by MRI allowed the identification of new aspects of brain damage in sepsis, including cytotoxic and vasogenic edema as well as neuronal damage. These findings highlight the potential applications of MRI techniques for the diagnostic and therapeutic studies in sepsis.

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Effect of tumor necrosis factor-alpha on the permeability of bovine brain microvessel endothelial cell monolayers

Cited by 41 publications

References 0 publications

Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex

Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex

The Effect of Antioxidant Caffeic Acid Phenethyl Ester (Cape) on Some Enzyme Activities in Cisplatin-Induced Neurotoxicity in Rats

Sepsis-Associated Encephalopathy: A Magnetic Resonance Imaging and Spectroscopy Study

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