Effect of Triton WR 1339 on cancer dissemination and metastases

Inhibition of Metastatic Spread by I.C.R.F. 159: Selective Deletion of a Malignant Characteristic

“…Few attempts have been made to find new substances which prevent tumour cell dissemination (Handler, Sarris, and Wills, 1964; Rosso, Donelli, Franchi, and Garattini, 1969). This may largely be due to the difficulty of finding suitable experimental models, and most other workers have therefore bypassed the problem by injecting tumour cells intravenously.…”

Biomedical Vignette

“…Triton WR-1339, a cross-linked form of Triton X-100, has been shown to suppress the dissemination and metastasis of certain tumors [21]. Contrary to these results, others have reported that WR-1339 actually increases the chance that certain tumor cells will metastasize [19].…”

Antimetastatic effect of Triton WR 1339, a nonionic detergent, on rat ascites tumors.

“…For this reason studies have been made on the drugs which prevent the dissemination of tumor cells selectively (Rosso et al 1969;Burrage et al 1970;Franchi et al 1971;Le Serve and Hellmann 1972;Atherton et al 1975;Giraldi et al 1977).…”

“…It was reported that Triton WR 1339 may interfere with the lodgement of tumor cells and thus inhibit the metastatic spread (Rosso et al 1969;Franchi et al 1971). Le Serve and Hellmann (1972) reported that inhibition of metastasis by ICRF 159 is due to the poor angiogenesis at the margins of a primary tumor.…”