Effect of triiodothyronine on postischemic myocardial function in the isolated heart

Kadletz, Margit; Mullen, Patrick G.; Ding, Mai; Wolfe, Luke; Wechsler, Andrew S.

doi:10.1016/0003-4975(94)90563-0

Cited by 23 publications

(9 citation statements)

References 15 publications

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“…It has long been observed that administration of TH at reperfusion can improve post-ischemic left ventricular function in animal models of ischemia-reperfusion and in patients undergoing GABG [118][119][120][121][122][123][124][125] (Fig. 7).…”

Section: Th Limits Reperfusion Injurymentioning

confidence: 95%

New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?

2010

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Chronic ischemia or pressure overload decreases thyroid hormone (TH) signaling and activates the fetal gene program in the heart. While these features are of physiologic importance in the developing heart, their respective roles in the postnatal heart are debated. Administration of TH can prevent the changes of the fetal gene program and rebuild the heart after an "index event" such as ischemia. TH affects cardiac remodeling by limiting reperfusion injury, and, at later states, by inducing distinct changes in cardiac chamber geometry in a time-dependent manner. Furthermore, administration of TH can convert pathologic to physiologic hypertrophy. These effects are the result of favorable cellular remodeling. While preliminary clinical studies provide encouraging results, the potential and efficacy of TH in the treatment of heart disease still await evaluation in large clinical trials.

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Section: Th Limits Reperfusion Injurymentioning

confidence: 95%

New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?

2010

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“…Thyroid hormones (THs) are inotropic hormones, which could be potentially used to support hemodynamics [21,22,33,47,48]. Subsequently, several clinical studies appeared using triiodothyronine (T3) or thyroxine (T4) to treat heart failure.…”

Section: Introductionmentioning

confidence: 99%

Molecular and biochemical evidences on the protective effects of triiodothyronine against phosphine-induced cardiac and mitochondrial toxicity

et al. 2015

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“…Furthermore, T 3 and/or T 4 administration increased cell viability in neonatal cardiomyocytes subjected to hypoxia or to serum starvation [21,22]. A beneficial effect of thyroid hormone on reperfusion injury was also demonstrated in animal studies and recently in humans [5,[23][24][25][26][27][28][29].…”

Section: Thyroid Hormone and Ischaemia-reperfusionmentioning

confidence: 88%

Thyroid hormone and myocardial ischaemia

Pantos

Mourouzis

Xinaris

et al. 2008

The Journal of Steroid Biochemistry and Molecular Biology

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Effect of triiodothyronine on postischemic myocardial function in the isolated heart

Cited by 23 publications

References 15 publications

New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?

New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?

Molecular and biochemical evidences on the protective effects of triiodothyronine against phosphine-induced cardiac and mitochondrial toxicity

Thyroid hormone and myocardial ischaemia

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