Effect of triiodothyronine on 5-HT1A and 5-HT1B receptor expression in rat forebrain and on latency to feed in the novelty suppressed feeding test

Lifschytz, Tzuri; Goltser-Dubner, Tanya; Landshut, Galit; Lerer, Bernard

doi:10.1016/j.pnpbp.2010.02.029

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…Several lines of evidence also support a relationship between thyroid hormones and serotonergic transmission in the brain (Sandrini et al, 1996; Gur et al, 1999; Lifschytz et al, 2004). It was speculated that the serotonergic system play a role in the pathogenesis of depression by modulating thyroid hormones effect (Bauer et al, 2002), as suggested by the T 3‐ induced potentiation of therapeutic actions of serotonergic antidepressant (Lifschytz et al, 2006, 2012). The peripheral nervous system has also been found to be dependent on the thyroid status.…”

Section: Introductionmentioning

confidence: 99%

Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

Hassan

Rahman

Aly

et al. 2013

Intl J of Devlp Neuroscience

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The present study was conducted to investigate the effect of experimentally-induced hyperthyroidism on dopamine (DA), norepinephrine (NE) and serotonin (5-HT) levels in different brain regions as well as in blood plasma, cardiac muscle and adrenal gland of young and adult male albino rats (60 rats of each age). Hyperthyroidism was induced by daily s.c. injection of L-thyroxine (L-T4, 500 μg/kg body wt.) for 21 consecutive days. Induction of hyperthyroidism caused a significant elevation in DA and 5-HT levels in most of the tissues studied of both young and adult animals after 7, 14, and 21 days. NE content significantly decreased after 21 days in most of the brain regions examined and after 14 and 21 days in blood plasma of young rats following hyperthyroidism. In adult rats, NE content decreased after 14 and 21 days in cardiac muscle and after 21 days only in adrenal gland. It may be suggested that the changes in monoamines level induced by hyperthyroidism may be due to disturbance in the synthesis, turnover and release of these amines through the neurons impairment or may attributed to an alteration pattern of their synthesis and/or degradative enzymes or changes in the sensitivity of their receptors.

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Section: Introductionmentioning

confidence: 99%

Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

Hassan

Rahman

Aly

et al. 2013

Intl J of Devlp Neuroscience

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“…This may suggest that, similarly to the rat model, thyroid hormones may be involved in the molecular mechanisms by which early trauma leads to persistent alterations in stress responses (Mitchell et al, 1990b) and consequently to higher vulnerability to psychopathology (MacMillan et al, 2001) (Mello et al, 2009), (Heim and Nemeroff, 2001;Kunugi et al, 2010). In agreement with this hypothesis, an experimental study in male and female mice shows that T3 administration is able to decrease depression-like behavior in specific tasks such as the novelty suppressed feeding and tail suspension tests (Lifschytz et al, 2010).…”

Section: Discussionmentioning

confidence: 87%

Early life trauma is associated with decreased peripheral levels of thyroid‐hormone T3 in adolescents

Machado

Salum

Bosa

et al. 2015

Intl J of Devlp Neuroscience

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An adverse early life environment can induce changes on behavioral and metabolic responses later in life. Recent studies in rats showed that the quality of maternal care as measured by high levels of pup licking and grooming (LG) was associated with changes in the relationship between the precursor thyroid-hormone T4 and the more active T3. Here we investigated if early exposure to childhood abuse is associated with thyroid-hormone levels in human adolescents. Given the empirical evidence from animal models showing that good maternal care was associated with increased conversion of T4 to T3, we hypothesized that early adversity would be associated with a decreased peripheral conversion of T4 to T3. A sample of 80 adolescents (10-18 years) participated in this study. We used the Childhood Trauma Questionnaire to investigate early life stress. We calculate the body mass index (BMI) assessing weight and height and sexual maturation stage was determined by self-assessment. Blood samples were collected to measure T3 and T4 levels. ANCOVA were used to evaluate the influence of the Physical Abuse domain of the Childhood Trauma Questionnaire as the early life stress variable in T3 and T4 separately, adjusted for potential confounders such as pubertal status, gender, socioeconomic status and BMI. Early life trauma was associated with reduced T3 levels in adolescents, when adjusted for potential confounders (p=0.013), but not with peripheral T4 levels (p=0.625). We extended findings from animal models showing that adverse early experience persistently impacts on the individual's responses to stress, which is marked by an abnormal metabolism of thyroid hormones. Further studies are needed to further investigate the nature of such associations.

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“…A one-week administration of T 3 was used since this is the duration typically used in similar animal studies 11,13,23. However, a recent study reported that coadministration of T 3 and the selective serotonin reuptake inhibitor, fluoxetine, for 3 weeks caused greater increases in neurogenesis in the hippocampus than fluoxetine administration alone 24.…”

Section: Discussionmentioning

confidence: 99%

Effect of triiodothyronine (T3) augmentation of acute milnacipran administration on monoamine levels: an in vivo microdialysis study in rats

Kitaichi

Inoue

Nakagawa³

et al. 2012

NDT

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BackgroundUp to 30% of depressed patients are partially or totally resistant to antidepressant therapy. The administration of triiodothyronine (T3) to antidepressant nonresponders can be an effective augmentation strategy, although the mechanism is not fully understood.MethodsIn vivo microdialysis was used to examine the effect of T3 augmentation of the antidepressant, milnacipran. Basal extracellular serotonin, norepinephrine, and dopamine levels were measured before and after acute milnacipran administration in the medial prefrontal cortex and amygdala of rats which had received subchronic (7 days) T3 treatment or control saline.ResultsSubchronic administration of T3 at 0.1 mg/kg significantly increased basal extracellular levels of serotonin in the medial prefrontal cortex, but not in the amygdala. In contrast, subchronic administration of T3 at 0.2 mg/kg did not alter basal extracellular serotonin levels in the medial prefrontal cortex. Basal extracellular levels of norepinephrine and dopamine were not modified by either dose of T3 in either region. Acute administration of milnacipran, a serotonin-norepinephrine reuptake inhibitor, to control animals resulted in a significant increase of extracellular levels of serotonin, norepinephrine, and dopamine. When administered to animals treated subchronically with T3 at 0.1 mg/kg, milnacipran produced an additional increase in extracellular serotonin levels but not in levels of norepinephrine or dopamine in the medial prefrontal cortex of rats.ConclusionThese results suggest that the mechanism of the augmentation effect of milnacipran by T3 administration occurs via enhancement of serotonergic neurotransmission, but not through noradrenergic or dopaminergic neurotransmission.

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Effect of triiodothyronine on 5-HT1A and 5-HT1B receptor expression in rat forebrain and on latency to feed in the novelty suppressed feeding test

Cited by 6 publications

References 36 publications

Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

Early life trauma is associated with decreased peripheral levels of thyroid‐hormone T3 in adolescents

Effect of triiodothyronine (T3) augmentation of acute milnacipran administration on monoamine levels: an in vivo microdialysis study in rats

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